The Eicosanoids

Copyright © 2004 John Wiley & Sons, Ltd

The Eicosanoids

Editor(s): Peter Curtis-Prior

Published Online: 13 JUL 2004

Print ISBN: 9780471489849

Online ISBN: 9780470020623

DOI: 10.1002/0470020628

About this Book

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About The Product

This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide.

This book satisfies a surge of interest in prostaglandins-NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xx)

  2. Part ONE: Biosynthesis and Metabolism

    1. Chapter 1

      Perspectives on the Biosynthesis and Metabolism of Eicosanoids (pages 1–16)

      Robert C. Murphy, Rebecca C. Bowers, Jennifer Dickinson and Karin Zemski Berry

    2. Chapter 2

      Control of Eicosanoid Production by Cellular and Secreted Phospholipase A2 (pages 17–27)

      Marise Andreani, Jean-Luc Olivier and Gilbert Béréziat

    3. Chapter 3

      Mechanisms of PGH Synthase-1 (COX-1) Activity and Role of Radical States (pages 29–42)

      Carol Deby and Ginette Deby-Dupont

    4. Chapter 4

      Regulation and Function of Prostaglandin Synthase 2/Cyclooxygenase II (pages 43–52)

      Harvey R. Herschman

    5. Chapter 5

      Mammalian Lipoxygenases (pages 53–59)

      Shozo Yamamoto, Hiroshi Suzuki, Natsuo Ueda, Yoshitaka Takahashi and Tanihiro Yoshimoto

    6. Chapter 6

      Biosynthesis and Biological Effects of 5-oxo-ETE and Other Oxoeicosatetraenoic Acids (pages 61–68)

      William S. Powell

    7. Chapter 7

      Synthetic Eicosanoids (pages 69–94)

      Norrie H. Wilson

  3. Part TWO: Analytical Methods

    1. Chapter 8

      Perspectives of Analytical Methods for Eicosanoids (pages 95–102)

      Jay Y. Westcott and Angelo Sala

    2. Chapter 9

      Enzyme Immunoassays of Metabolites and Enzymes Using Acetylcholinesterase as Label (pages 103–109)

      Christophe Créminon and Jacques Maclouf

    3. Chapter 10

      Bioassay of Eicosanoids (pages 111–116)

      Robert L. Jones

    4. Chapter 11

      Gas Chromatography and Mass Spectrometry in Eicosanoid Analysis (pages 117–121)

      Michinao Mizugaki, Takanori Hishinuma, Naoto Suzuki and Junichi Goto

    5. Chapter 12

      Time-Resolved Fluoroimmunoassay in Eicosanoid Analysis (pages 123–127)

      Werner Schlegel and Harald John

  4. Part THREE: Biochemical and Molecular Pharmacology

    1. Chapter 13

      Perspectives and Clinical Significance of the Biochemical and Molecular Pharmacology of Eicosanoids (pages 129–162)

      Subhash P. Khanapure and L. Gordon Letts

    2. Chapter 14

      Eicosanoid Antagonists (pages 163–178)

      Kiyoshi Yasui and Akinori Arimura

    3. Chapter 15

      Biosynthesis and Degradation of Anandamide, An Endogenous Ligand of Cannabinoid Receptors (pages 179–187)

      Natsuo Ueda and Dale G. Deutsch

    4. Chapter 16

      Inhibitors of Eicosanoids (pages 189–210)

      K. D. Rainsford

    5. Chapter 17

      Biology and Chemistry of Products of the Isoprostane Pathway (pages 211–217)

      L. Jackson Roberts and Jason D. Morrow

    6. Chapter 18

      Insight into Prostanoid Functions: Lessons from Receptor-Knockout Mice (pages 219–225)

      Yukihiko Sugimoto, Shuh Narumiya and Atsushi Ichikawa

  5. Part FOUR: Immunology, Endocrinology and Metabolic Regulation

    1. Chapter 19

      Perspectives and Clinical Significance of Eicosanoids in Immunology, Endocrinology and Metabolic Regulation (pages 227–236)

      Milan R. Henzl

    2. Chapter 20

      Prostaglandins and the Immune Response (pages 237–245)

      Diana C. Fleming and Rodney W. Kelly

    3. Chapter 21

      Leukotrienes in Aspirin-Intolerant Asthma (pages 247–255)

      Anthony P. Sampson and Stephen T. Holgate

    4. Chapter 22

      Essential Fatty Acids (pages 257–265)

      Yoeju Min and Michael A. Crawford

    5. Chapter 23

      Endothelial Secretory Function and Atherothrombosis (pages 267–276)

      Stefan Chlopicki and Richard J. Gryglewski

    6. Chapter 24

      Molecular Regulation of Pancreatic Islet Prostaglandin Synthesis and Its Relevance to Diabetes Mellitus (pages 277–287)

      R. Paul Robertson

    7. Chapter 25

      Prostaglandins, Leukotrienes and Bone (pages 289–297)

      Carol C. Pilbeam and Lawrence G. Raisz

    8. Chapter 26

      Ageing and Prostaglandins (pages 299–318)

      A. Hornych

  6. Part FIVE: Inflammation

    1. Chapter 27

      Perspectives and Clinical Significance of Eicosanoids in Pain and Inflammation (pages 319–325)

      Burkhard Hinz and Kay Brune

    2. Chapter 28

      Antiinflammatory Steroids (pages 327–332)

      Françoise Russo-Marie

    3. Chapter 29

      Eicosanoids and Algesia in Inflammation (pages 333–339)

      Lynne Murray, Henry Sarau and Kristen E. Belmonte

    4. Chapter 30

      Cyclooxygenase-2 in Cancer (pages 341–346)

      Ovidiu C. Trifan and Jaime L. Masferrer

    5. Chapter 31

      Cytokines and Eicosanoids in Arthritis (pages 347–358)

      K. D. Rainsford

  7. Part SIX: Circulatory System

    1. Chapter 32

      Perspectives and Clinical Significance of Eicosanoids in the Circulatory System (pages 359–371)

      James B. Lee

    2. Chapter 33

      Aspirin and Activated Platelets (pages 373–385)

      Artur-Aron Weber

    3. Chapter 34

      Generation of Vasoactive Prostanoids by the Cyclooxygenase-2 Pathway in the Cardiovascular System of the Rat (pages 387–392)

      P. J. Kadowitz, S. R. Baber, M. M. Mazim, M. Keebler, H. C. Champion, T. J. Bivalacqua, D. B. McNamara and A. L. Hyman

    4. Chapter 35

      Eicosanoid Generation and Effects in Cardiac Muscle and Coronary Vessels (pages 393–404)

      Karsten Schrör

  8. Part SEVEN: Digestive System

    1. Chapter 36

      Perspectives and Clinical Significance of Eicosanoids in the Digestive System (pages 405–414)

      Chi Hin Cho, Joshua Ka Shun Ko and Marcel Wing Leung Koo

    2. Chapter 37

      Eicosanoids and Liver Regeneration (pages 415–421)

      David A. Rudnick and Louis J. Muglia

    3. Chapter 38

      Eicosanoids and the Intestine (pages 423–429)

      Klaus Bukhave and Jørgen Rask-Madsen

    4. Chapter 39

      Eicosanoids and Stomach Physiology (pages 431–444)

      Brigitta M. Peskar

  9. Part EIGHT: Nervous System

    1. Chapter 40

      Perspectives and Clinical Significance of Arachidonic Acid Release, Action and Metabolism in the Nervous System (pages 445–456)

      Christopher D. Breder

    2. Chapter 41

      Eicosanoid Pathways in the Ageing of the Central Nervous System (pages 457–462)

      Hari Manev and Tolga Uz

    3. Chapter 42

      Arachidonate Metabolites in the Neurophysiological System: The Fever Pathway (pages 463–472)

      Ji Zhang and Serge Rivest

    4. Chapter 43

      Prostanoids in Pain (pages 473–480)

      Tony L. Yaksh, Patrick W. Mantyh and Camilla I. Svensson

    5. Chapter 44

      Eicosanoids: Roles in the Pathophysiology of Cerebral Ischaemia (pages 481–486)

      Robert W. Hickey and Steven H. Graham

    6. Chapter 45

      NSAIDs in the Treatment of Alzheimer's Disease (pages 487–491)

      Paul S. Aisen

    7. Chapter 46

      Prostaglandins and Eicosanoids in Mental Illness (pages 493–498)

      A. I. M. Glen and B. M. Ross

    8. Chapter 47

      Essential Fatty Acids: Eicosanoid Precursors in the Treatment of Huntington's Disease (pages 499–506)

      Krishna Vaddadi

  10. Part NINE: Reproductive System

    1. Chapter 48

      Perspectives and Clinical Significance of Eicosanoids in Obstetric and Gynaecological Practice (pages 507–515)

      I. Z. MacKenzie

    2. Chapter 49

      Prostaglandins and Male Reproductive Physiology (pages 517–524)

      Rodney W. Kelly

    3. Chapter 50

      Prostaglandin F2α: The Luteolytic Hormone (pages 525–545)

      John A. McCracken

    4. Chapter 51

      Prostaglandins in Implantation (pages 547–557)

      Norman L. Poyser

    5. Chapter 52

      Parturition and the Clinical Interruption of Pregnancy (pages 559–568)

      S. Cowan and A. A. Calder

    6. Chapter 53

      Foetal and Neonatal Ductus Arteriosus (pages 569–581)

      Kazuo Momma

  11. Part TEN: Conclusions and Correlations

    1. Chapter 54

      Biochemical Interactions of Platelet-Activating Factor with Eicosanoids (pages 583–592)

      Joseph T. O'Flaherty and Robert L. Wykle

    2. Chapter 55

      Eicosanoid Precursors as Pharmaceuticals (pages 593–598)

      David F. Horrobin

    3. Chapter 56

      Pharmaceutical Exploitation: Cyclooxygenase and Lipoxygenase Inhibitors (pages 599–612)

      Paola Patrignani and Maria G. Sciulli

    4. Chapter 57

      Pharmaceutical Exploitation: Eicosanoids and Their Analogues (pages 613–616)

      David F. Woodward and June Chen

    1. You have free access to this content
      Epilogue (pages 617–618)

    1. You have free access to this content
      Index (pages 619–634)

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