Neurodegenerative Diseases and Metal Ions, Volume 1

Neurodegenerative Diseases and Metal Ions, Volume 1

Editor(s): Astrid Sigel, Helmut Sigel, Roland K. O. Sigel

Published Online: 27 JUL 2006

Print ISBN: 9780470014882

Online ISBN: 9780470028117

DOI: 10.1002/0470028114

About this Book

About the Series...

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry.

About this Book...

Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject.

Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Table of contents

    1. You have free access to this content
    2. Chapter 2

      Protein Folding, Misfolding, and Disease (pages 9–60)

      Jennifer C. Lee, Judy E. Kim, Ekaterina V. Pletneva, Jasmin Faraone-Mennella, Harry B. Gray and Jay R. Winkler

    3. Chapter 3

      Metal Ion Binding Properties of Proteins Related to Neurodegeneration (pages 61–87)

      Henryk Kozlowski, Marek Luczkowski, Daniela Valensin and Gianni Valensin

    4. Chapter 6

      The Role of Iron in the Pathogenesis of Parkinson's Disease (pages 125–149)

      Manfred Gerlach, Kay L. Double, Mario E. Götz, Moussa B. H. Youdim and Peter Riederer

    5. You have free access to this content