Principles of Mass Spectrometry Applied to Biomolecules

Copyright © 2006 John Wiley & Sons, Inc.

Principles of Mass Spectrometry Applied to Biomolecules

Editor(s): Julia Laskin, Chava Lifshitz

Published Online: 6 MAR 2006

Print ISBN: 9780471721840

Online ISBN: 9780470050422

DOI: 10.1002/047005042X

About this Book

Product Information

About The Product

An extensive compilation of articles by leading professionals, this reference explains the fundamental principles of mass spectrometry as they relate to the life sciences. Topics covered include spectroscopy, energetics and mechanisms of peptide fragmentation, electron capture dissociation, ion-ion and ion-molecule reactions, reaction dynamics, collisional activation, soft-landing, protein structure and interactions, thermochemistry, and more. The book empowers readers to develop new ways of using these techniques.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xviii)

  2. Part I: Structures and Dynamics of Gas-Phase Biomolecules

    1. Chapter 1

      Spectroscopy of Neutral Peptides in the Gas Phase: Structure, Reactivity, Microsolvation, Molecular Recognition (pages 1–61)

      Markus Gerhards

    2. Chapter 2

      Probing the Electronic Structure of Fe[BOND]S Clusters: Ubiquitous Electron Transfer Centers in Metalloproteins Using Anion Photoelectron Spectroscopy in the Gas Phase (pages 63–117)

      Xin Yang, Xue-Bin Wang, You-Jun Fu and Lai-Sheng Wang

    3. Chapter 3

      Ion–Molecule Reactions and H/D Exchange for Structural Characterization of Biomolecules (pages 119–145)

      M. Kirk Green and Carlito B. Lebrilla

    4. Chapter 4

      Understanding Protein Interactions and Their Representation in the Gas Phase of the Mass Spectrometer (pages 147–175)

      Frank Sobott and Carol V. Robinson

    5. Chapter 5

      Protein Structure and Folding in the Gas Phase: Ubiquitin and Cytochrome c (pages 177–212)

      Kathrin Breuker

    6. Chapter 6

      Dynamical Simulations of Photoionization of Small Biological Molecules (pages 213–237)

      Dorit Shemesh and R. Benny Gerber

    7. Chapter 7

      Intramolecular Vibrational Energy Redistribution and Ergodicity of Biomolecular Dissociation (pages 239–275)

      Chava Lifshitz

  3. Part II: Activation, Dissociation, and Reactivity

    1. Chapter 8

      Peptide Fragmentation Overview (pages 277–300)

      Vicki H. Wysocki, Guilong Cheng, Qingfen Zhang, Kristin A. Herrmann, Richard L. Beardsley and Amy E. Hilderbrand

    2. Chapter 9

      Peptide Radical Cations (pages 301–335)

      Alan C. Hopkinson and K. W. Michael Siu

    3. Chapter 10

      Photodissociation of Biomolecule Ions: Progress, Possibilities, and Perspectives Coming from Small-Ion Models (pages 337–377)

      Robert C. Dunbar

    4. Chapter 11

      Chemical Dynamics Simulations of Energy Transfer and Unimolecular Decomposition in Collision-Induced Dissociation (CID) and Surface-Induced Dissociation (SID) (pages 379–432)

      Asif Rahaman, William L. Hase, Kihyung Song, Jiangping Wang and Samy O. Meroueh

    5. Chapter 12

      Ion Soft Landing: Instrumentation, Phenomena, and Applications (pages 433–474)

      Bogdan Gologan, Justin M. Wiseman and R. Graham Cooks

    6. Chapter 13

      Electron Capture Dissociation and Other Ion–Electron Fragmentation Reactions (pages 475–517)

      Roman Zubarev

    7. Chapter 14

      Biomolecule Ion–Ion Reactions (pages 519–564)

      Scott A. McLuckey

  4. Part III: Thermochemistry and Energetics

    1. Chapter 15

      Thermochemistry Studies of Biomolecules (pages 565–617)

      Chrys Wesdemiotis and Ping Wang

    2. Chapter 16

      Energy and Entropy Effects in Gas-Phase Dissociation of Peptides and Proteins (pages 619–665)

      Julia Laskin

    1. You have free access to this content
      Index (pages 667–687)

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