New Treatment Strategies for Dengue and Other Flaviviral Diseases: Novartis Foundation Symposium 277

New Treatment Strategies for Dengue and Other Flaviviral Diseases: Novartis Foundation Symposium 277

Editor(s): Gregory Bock, Jamie Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470016435

Online ISBN: 9780470058008

DOI: 10.1002/0470058005

Series Editor(s): Novartis Foundation

About this Book

Dengue virus is a member of the Flaviviridae family, which includes viruses associated with human diseases such as yellow fever, Japanese encephalitis and hepatitis C. Dengue fever is transmitted by mosquitoes, principally Aedes aegypti. There are four serotypes of dengue virus, of which DENV-2 has been the most prevalent in many recent epidemics. Following primary infection, lifelong immunity develops, preventing repeated assault by the same serotype. However, the non-neutralizing antibodies from a previous infection or maternally acquired antibodies are thought to form complexes with a different serotype during a subsequent infection and cause dengue haemorrhagic fever/dengue shock syndrome, which can be fatal. There is no treatment or vaccine available today that can combat this emerging and uncontrolled disease.

This book features contributions from the world's leading researchers working on dengue and related flaviviruses who examine the current state of the art in the molecular biology of the dengue virus. Particular emphasis is placed on the structure and function of the virus and the targeting of virus proteins by potential antiviral agents. The pathogenesis of dengue and dengue haemorrhagic fever are discussed in detail, especially the target cells and the specific receptors on these cells, thereby developing a clear overview of host and viral factors that contribute to dengue haemorrhagic fever. Finally, the book reviews the therapeutic options, paying particular attention to ways in which vector, host and environment can play a critical role in the spread of this disease.

With dengue fever and other emerging viral diseases becoming increasingly prevalent around the world, this book provides valuable insight into the virus that causes this disease and potential ways to manage it. It is essential reading for all those working in tropical diseases, public health and virology.

Praise from the reviews:

"The book provides an excellent summary of dengue/flavivirus research and is important for individuals and institutions interested in emerging infectious diseases." MICROBIOLOGY TODAY

Table of contents

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    2. Molecular Biology of Flaviviruses (pages 23–40)

      Eva Harris, Katherine L. Holden, Dianna Edgil, Charlotta Polacek and Karen Clyde

    3. Multiple Enzyme Activities of Flavivirus Proteins (pages 74–86)

      R. Padmanabhan, N. Mueller, E. Reichert, C. Yon, T. Teramoto, Y. Kono, R. Takhampunya, S. Ubol, N. Pattabiraman, B. Falgout, V. K. Ganesh and K. Murthy

    4. Finding New Medicines for Flaviviral Targets (pages 102–119)

      Thomas H. Keller, Yen Liang Chen, John E. Knox, Siew Pheng Lim, Ngai Ling Ma, Sejal J. Patel, Aruna Sampath, Qing Yin Wang, Zheng Yin and Subhash G. Vasudevan

    5. Structural and Functional Analysis of Dengue Virus RNA (pages 120–135)

      Diego E. Alvarez, Maria F. Lodeiro, Claudia V. Filomatori, Silvana Fucito, Juan A. Mondotte and Andrea V. Gamarnik

    6. A Genomics Approach to Understanding Host Response during Dengue Infection (pages 206–217)

      Martin L. Hibberd, Ling Ling, Thomas Tolfvenstam, Wayne Mitchell, Chris Wong, Vladimir A. Kuznetsov, Joshy George, Swee-Hoe Ong, Yijun Ruan, Chia L. Wei, Feng Gu, Joshua Fink, Andy Yip, Wei Liu, Mark Schreiber and Subhash G. Vasudevan

    7. You have free access to this content
    8. You have free access to this content