Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function: Novartis Foundation Symposium 254

Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function: Novartis Foundation Symposium 254

Editor(s): Gregory Bock, Jamie Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470853566

Online ISBN: 9780470090763

DOI: 10.1002/0470090766

Series Editor(s): Novartis Foundation

About this Book

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field.

Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems.

This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics.

The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research.

Related Novartis Foundation symposia:

247 In Silico Simulation of Biological Processes
Chair: Denis Noble

252 Generation and effector functions of regulatory lymphocytes
Chair: Jean-François Bach

Table of contents

    1. You have free access to this content
    2. Computational Vaccinology: Quantitative Approaches (pages 102–125)

      Darren R. Flower, Helen McSparron, Martin J Blythe, Christianna Zygouri, Debra Taylor, Pingping Guan, Shouzhan Wan, Peter V. Coveney, Valerie Walshe, Persephone Borrow and Irini A. Doytchinova

    3. Viral Bioinformatics: Computational Views of Host and Pathogen (pages 234–249)

      Paul Kellam, Ria Holzerlandt, Eva Gramoustianou, Richard Jenner and Antonia Kwan

    4. You have free access to this content
    5. You have free access to this content