Mechanisms of Drug Resistance in Epilepsy: Novartis Foundation Symposium 243

Copyright © Novartis Foundation 2002

Mechanisms of Drug Resistance in Epilepsy: Novartis Foundation Symposium 243

Editor(s): Gregory Bock, Jamie A. Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470841464

Online ISBN: 9780470846353

DOI: 10.1002/0470846356

Series Editor(s): Novartis Foundation

About this Book

Product Information

About The Product

The object of this book is to gather together workers in the fields of epilepsy, those concerned with the basic science of resistance and the blood-brain barrier, and those with clinical experience of drug resistance in cancer, with a view to stimulating further work on drug resistance in epilepsy. Whilst resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken, with some success, resistance in epilepsy has only just begun to be addressed.

Table of contents

    1. You have free access to this content
      Front Matter and Index (pages i–viii)

    2. Chair's Introduction (pages 1–3)

      Victor Ling

    3. The Problem of the Drug-Resistant Epilepsies (pages 4–18)

      J. W. Sander

    4. Drug Resistance Molecules: Lessons from Oncology (pages 19–37)

      George L. Scheffer and Rik. J. Scheper

    5. Drug Resistance in Epilepsy: The Role of the Blood–Brain Barrier (pages 38–53)

      N. Joan Abbott, Ehsan U. Khan, Christopher M. S. Rollinson, Andreas Reichel, Damir Janigro, Stephen M. Dombrowski, Michael S. Dobbie and David J. Begley

    6. P glycoprotein and the Mechanism of Multidrug Resistance (pages 54–68)

      András Váradi, Gergely Szakács, Éva Bakos and Balázs Sarkadi

    7. Drug Resistance Caused by Multidrug Resistance-Associated Proteins (pages 69–82)

      Jan Wijnholds

    8. Reversal of Multidrug Resistance: Lessons from Clinical Oncology (pages 83–102)

      Susan E. Bates, Clara Chen, Robert Robey, Min Kang, William D. Figg and Tito Fojo

    9. Clinical Development of P glycoprotein Modulators in Oncology (pages 103–118)

      Amit M. Oza

    10. Gene Expression Profiling of Epothilone A-Resistant Cells (pages 119–136)

      Peter Atadja, Yan Yan-Neale, Harry Towbin, Frank Buxton and Dalia Cohen

    11. Imaging of P glycoprotein Function in vivo with PET (pages 137–148)

      N. H. Hendrikse and W. Vaalburg

    12. Animal Models of Drug-Resistant Epilepsy (pages 149–166)

      Wolfgang Löscher

    13. Drug Resistance in Epilepsy: Human Epilepsy (pages 167–179)

      S. M. Sisodiya, W.-R. Lin, B. N. Harding, M. V. Squier and M. Thom

    14. General Discussion I (pages 180–185)

    15. Cellular Mechanisms of Pharmacoresistance in Slices from Epilepsy Surgery (pages 186–206)

      R. A. Deisz

    16. Functional Polymorphisms of the Human Multidrug Resistance (MDR1) Gene: Correlation with P glycoprotein Expression and Activity in vivo (pages 207–212)

      Ulrich Brinkmann

    17. OC144-093, a Novel P glycoprotein Inhibitor for the Enhancement of Anti-Epileptic Therapy (pages 213–230)

      Michael J. Newman, Ross Dixon and Barry Toyonaga

    18. Final General Discussion (pages 231–235)

    19. Closing Remarks (page 236)

      Victor Ling

    20. You have free access to this content
      Index of Contributors (pages 237–238)

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