Cancer and Inflammation: Novartis Foundation Symposium 256

Cancer and Inflammation: Novartis Foundation Symposium 256

Editor(s): Derek J. Chadwick, Jamie A. Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470855102

Online ISBN: 9780470856734

DOI: 10.1002/0470856734

Series Editor(s): Novartis Foundation

About this Book

Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems.

Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response.

This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies.

Related Novartis Foundation symposia:
252 Generation and Effector Functions of Regulatory Lymphocytes
Chair: Jean-François Bach

254 Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function
Chair: Hans-Georg Rammensee

Table of contents

    1. You have free access to this content
    2. Anti- TNFα Therapy of Rheumatoid Arthritis: What Can We Learn about Chronic Disease? (pages 53–73)

      Marc Feldmann, Fionula M. Brennan, Ewa Paleolog, Andrew Cope, Peter Taylor, Richard Williams, Jim Woody and Ravinder N. Maini

    3. The Influence of CD25+ Cells on the Generation of Immunity to Tumour Cell Lines in Mice (pages 149–157)

      Emma Jones, Denise Golgher, Anna Katharina Simon, Michaela Dahm-Vicker, Gavin Screaton, Tim Elliott and Awen Gallimore

    4. Chemokines: Angiogenesis and Metastases in Lung Cancer (pages 173–188)

      Robert M. Strieter, John A. Belperio, Roderick J. Phillips and Michael P. Keane

    5. In vivo Manipulation of Dendritic Cell Migration and Activation to Elicit Antitumour Immunity (pages 241–258)

      Alain P. Vicari, Béatrice Vanbervliet, Catherine Massacrier, Claudia Chiodoni, Céline Vaure, Smina Aït-Yahia, Christophe Dercamp, Fabien Matsos, Olivier Reynard, Catherine Taverne, Philippe Merle, Mario P. Colombo, Anne O'Garra, Giorgio Trinchieri and Christophe Caux

    6. You have free access to this content
    7. You have free access to this content