‘In Silico’ Simulation of Biological Processes: Novartis Foundation Symposium 247

‘In Silico’ Simulation of Biological Processes: Novartis Foundation Symposium 247

Editor(s): Gregory Bock, Jamie A. Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470844809

Online ISBN: 9780470857892

DOI: 10.1002/0470857897

Series Editor(s): Novartis Foundation

About this Book

Over recent decades vast amounts of biological data have been accumulated. However, it is becoming increasingly difficult to apply traditional theoretical methods to the formulation of coherent pictures of cell and organ function because it is no longer possible for a human theorist to integrate all of the available information. Instead, computer technologies must now be used to perform this integration. This book brings together contributions from many different fields to summarize the current status of computer-assisted modelling of biological processes.

The initial chapters deal with fundamental developments in hardware, software and mathematics that underlie current approaches to biological modelling. Next, different approaches to collating data on gene structure and function are presented. These databases form a vital resource for any investigator trying to construct an integrated picture of particular biological systems.

Cell signalling systems form a particularly complicated aspect of all cellular function and are important both in the understanding of basic cellular processes and in selecting targets for drugs. Recent approaches to integrating data on cell signalling into computer models are covered. Further chapters build on these approaches to show how computerized models of intact cells can be developed. Finally, approaches to the computer modelling of whole organs such as the heart are presented. The role of computer modelling in drug design is the subject of the final chapter and is also touched on throughout the discussions.

Table of contents

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    2. Imaging-Based Integrative Models of the Heart: Closing the Loop between Experiment and Simulation (pages 129–143)

      Raimond L. Winslow, Patrick Helm, William Baumgartner, Srinivas Peddi, Tilak Ratnanather, Elliot McVeigh and Michael I. Miller

    3. Using In Silico Biology to Facilitate Drug Development (pages 222–243)

      Jeremy M. Levin, R. Christian Penland, Andrew T. Stamps and Carolyn R. Cho

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