Mucus Hypersecretion in Respiratory Disease: Novartis Foundation Symposium 248

Mucus Hypersecretion in Respiratory Disease: Novartis Foundation Symposium 248

Editor(s): Derek J. Chadwick, Jamie A. Goode

Published Online: 17 MAY 2008

Print ISBN: 9780470844786

Online ISBN: 9780470860793

DOI: 10.1002/0470860790

Series Editor(s): Novartis Foundation

About this Book

A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanisms that underlie and maintain this hypersecretory phenotype is therefore crucial for the development of rational approaches to therapy.

Despite a high and increasing prevalence and cost to healthcare services and society, mucus hypersecretion in chronic respiratory disease has received little attention until recently, probably because of the difficulties inherent in studying this pathology. Only in the last few years have some of the genes involved in mucus secretion been characterized. The recent availability of genomic sequence information and specific antibodies has led to an explosion of interest in this area making this publication particularly timely.

This book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem. Coverage includes epidemiology, airways infection and mucus hypersecretion, the genetics and regulation of mucus production, models of mucus hypersecretion, and the implications of new knowledge for the development of novel therapies.

Table of contents

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    2. Mechanisms of Submucosal Gland Morphogenesis in the Airway (pages 38–50)

      Mohammed Filali, Xiaoming Liu, Ningli Cheng, Duane Abbott, Vladimir Leontiev and John F. Engelhardt

    3. Respiratory Tract Mucins: Structure and Expression Patterns (pages 76–93)

      Julia R. Davies, Annkatrin Herrmann, Wayne Russell, Naila Svitacheva, Claes Wickström and Ingemar Carlstedt

    4. A Calcium-Activated Chloride Channel Blocker Inhibits Goblet Cell Metaplasia and Mucus Overproduction (pages 150–170)

      Yuhong Zhou, Michael Shapiro, Qu Dong, Jamila Louahed, Christine Weiss, Shanhong Wan, Qiming Chen, Carl Dragwa, Dawn Savio, Minxue Huang, Catherine Fuller, Yaniv Tomer, Nicholas C. Nicolaides, Michael McLane and Roy C. Levitt

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