Anaphylaxis: Novartis Foundation Symposium 257

Anaphylaxis: Novartis Foundation Symposium 257

Editor(s): Gregory Bock, Jamie Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470861141

Online ISBN: 9780470861196

DOI: 10.1002/0470861193

Series Editor(s): Novartis Foundation

About this Book

Anaphylaxis is an immediate-type allergic reaction involving the whole organism. It is the most life-threatening allergic condition. Although there are few exact epidemiological data regarding prevalence, estimates regarding insect sting anaphylaxis range from 1-3% in the general population, but much higher values have been reported by some authors for food and drug-induced anaphylaxis. Anaphylaxis is the main acute killer of allergic individuals.
Although anaphylaxis was discovered at the beginning of the 20th century, there are still many unresolved issues. These include non-IgE-mediated anaphylactoid reactions, non-immunologically mediated anaphylactoid (pseudo-allergic) reactions, pathophysiological events at the microcirculatory level, appropriate therapy for the acute reaction, strategies for prevention, public education about the problem and new approaches to prevention and therapy at the IgE level. All these subjects are discussed in this book.
Since anaphylaxis occurs acutely and is unforeseen, it is very difficult to organize controlled studies regarding therapy and prevention. The spectrum of symptomatology covers many clinical areas (skin, respiratory, cardiovascular and gastrointestinal system), therefore inter-disciplinary approaches are necessary for progress in the field. There is widespread uncertainty among physicians about therapy, especially concerning self-administered treatment.
In this important book, an multidisciplinary group of experts explore the pathophysiology of different types of anaphylactic and anaphylactoid reactions. Evidence is presented on the epidemiology of these conditions while problems relating to diagnosis, therapy and prevention are examined in detail. This thorough and up-to-date coverage of the subject will be of great interest to all clinical immunologists, researchers and physicians who deal with this life-threatening condition.
Related Novartis Foundation symposia:
252 Generation and effector functions of regulatory lymphocytes
Chair: Jean-François Bach
* Immunoinformatics: bioinformatic strategies for better understanding of immune function
Chair: Hans-Georg Rammensee
* Cancer and inflammation
Chair: Siamon Gordon

Table of contents

    1. You have free access to this content
    2. Chapter 3

      Rethinking Th2 Antibody Responses and Allergic Sensitization (pages 25–44)

      Debra Stern, Waltraud Eder, Gina Tebow, I.Carla Lohman, Elisa Soprana, Charlotte Braun-Fahrländer, Josef Riedler, Dennis Nowak, Erika Von Mutius, Marilyn Halonen and Donata Vercelli

    3. Chapter 7

      Cytokine Enhancement of Anaphylaxis (pages 80–97)

      Richard Strait, Suzanne C. Morris and Fred D. Finkelman

    4. Chapter 11

      The Human Heart As a Shock Organ in Anaphylaxis (pages 133–156)

      Gianni Marone, Maria Bova, Aikaterini Detoraki, Anna Maria Onorati, Francesca W. Rossi and Giuseppe Spadaro

    5. Chapter 20

      New Approaches for the Treatment of Anaphylaxis (pages 248–264)

      Donald Y. M. Leung, William R. Shanahan, Xiu-Min Li and Hugh A. Sampson

    6. You have free access to this content
    7. You have free access to this content