Reversible Protein Acetylation: Novartis Foundation Symposium 259

Copyright © Novartis Foundation 2004

Reversible Protein Acetylation: Novartis Foundation Symposium 259

Editor(s): Gregory Bock, Jamie Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470862612

Online ISBN: 9780470862636

DOI: 10.1002/0470862637

Series Editor(s): Novartis Foundation

About this Book

Product Information

About The Product

A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–x)

    2. Chair's Introduction (pages 1–2)

      Eric Verdin

    3. Beyond the Double Helix: Writing and Reading the Histone Code (pages 3–21)

      Yanming Wang, Wolfgang Fischle, Wang Cheung, Steven Jacobs, Sepideh Khorasanizadeh and C. David Allis

    4. The Indexing Potential of Histone Lysine Methylation (pages 22–47)

      Gunnar Schotta, Monika Lachner, Antoine H. F. M. Peters and Thomas Jenuwein

    5. A Model for Step-Wise Assembly of Heterochromatin in Yeast (pages 48–62)

      Danesh Moazed, Adam D. Rudner, Julie Huang, Georg J. Hoppe and Jason C. Tanny

    6. H2B Ubiquitylation and De-Ubiquitylation in Gene Activation (pages 63–77)

      Anastasia Wyce, Karl W. Henry and Shelley L. Berger

    7. Structural and Chemical Basis of Histone Acetylation (pages 78–101)

      Ronen Marmorstein

    8. Phosphorylation and Acetylation of Histone H3 at Inducible Genes: Two Controversies Revisited (pages 102–114)

      Louis C. Mahadevan, Alison L. Clayton, Catherine A. Hazzalin and Stuart Thomson

    9. HDAC7 Regulates Apoptosis in Developing Thymocytes (pages 115–131)

      Eric Verdin, Frank Dequiedt and Herb Kasler

    10. Dual Roles of Histone Deacetylases in the Control of Cardiac Growth (pages 132–145)

      Timothy A. McKinsey and Eric N. Olson

    11. Chromatin Modifications as Clues to the Regulation of Antigen Receptor Assembly (pages 146–162)

      David Ciccone and Marjorie Oettinger

    12. General Discussion I (pages 163–169)

    13. The HDAC Complex and Cytoskeleton (pages 170–181)

      Jeffery J. Kovacs, Charlotte Hubbert and Tso-Pang Yao

    14. Tat Acetylation: A Regulatory Switch between Early and Late Phases in HIV Transcription Elongation (pages 182–196)

      Melanie Ott, Alexander Dorr, Claudia Hetzer-Egger, Katrin Kaehlcke, Martina Schnolzer, Peter Henklein, Phil Cole, Ming-Ming Zhou and Eric Verdin

    15. Dynamics of the p53 Acetylation Pathway (pages 197–207)

      Wei Gu, Jianyuan Luo, Chris L. Brooks, Anatoly Y. Nikolaev and Muyang Li

    16. Regulation of NF-κB Action by Reversible Acetylation (pages 208–222)

      Warner C. Greene and Lin-Feng Chen

    17. General Discussion II (pages 223–225)

    18. Reversal of Gene Silencing as a Therapeutic Target for Cancer—Roles for DNA Methylation and Its Interdigitation with Chromatin (pages 226–237)

      Stephen B. Baylin

    19. Transcription Regulation by Histone Deacetylases (pages 238–248)

      Shaowen Wang, Yan Yan-Neale, Marija Zeremski and Dalia Cohen

    20. Molecular and Cellular Basis for the Anti-Proliferative Effects of the HDAC Inhibitor LAQ824 (pages 249–268)

      Peter Atadja, Meier Hsu, Paul Kwon, Nancy Trogani, Kapil Bhalla and Stacy Remiszewski

    21. Histone Deacetylase Inhibitors: Development as Cancer Therapy (pages 269–284)

      Paul A. Marks, Victoria M. Richon, Wm Kevin Kelly, Judy H. Chiao and Thomas Miller

    22. General Discussion III (pages 285–288)

    23. You have free access to this content
      Index of Contributors (pages 289–290)

    24. You have free access to this content
      Subject Index (pages 291–300)

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