Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

Editor(s): Derek J. Chadwick, Jamie Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470850350

Online ISBN: 9780470868065

DOI: 10.1002/0470868066

Series Editor(s): Novartis Foundation

About this Book

The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat.  Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues.  The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood.

This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology.  The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine. 

Table of contents

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    2. Mouse Models for Cardiac Conduction System Development (pages 44–67)

      Andy Wessels, Aimee Phelps, Thomas C. Trusk, Dorene L. Davis, Angela V. Edwards, John B. E. Burch and Amy L. Juraszek

    3. Developmental Transitions in Cardiac Conduction (pages 68–79)

      Michiko Watanabe, Emil Thomas Chuck, Florence Rothenberg and David S. Rosenbaum

    4. Gap Junctional Connexins in the Developing Mouse Cardiac Conduction System (pages 80–109)

      L. Miquerol, L. Dupays, M. Théveniau-Ruissy, S. Alcoléa, T. Jarry-Guichard, P. Abran and D. Gros

    5. His–Purkinje Lineages and Development (pages 110–124)

      Robert G. Gourdie, Brett S. Harris, Jacqueline Bond, Angela M. Edmondson, Gang Cheng, David Sedmera, Terrence X. O'Brien, Takashi Mikawa and Robert P. Thompson

    6. The Role of Neural Crest and Epicardium-Derived Cells in Conduction System Formation (pages 125–141)

      Adriana C. Gittenberger-de Groot, Nico M. Blom, Naoyoshi Aoyama, Henri Sucov, Arnold C. G. Wenink and Robert E. Poelmann

    7. Induction and Patterning of the Purkinje Fibre Network (pages 142–156)

      Takashi Mikawa, Robert G. Gourdie, Kimiko Takebayashi-Suzuki, Nobuyuki Kanzawa, Jeanette Hyer, David J. Pennisi, Clifton P. Poma, Maxim Shulimovich, Kevin G. Diaz, John Layliev and Aparna Prasad

    8. The Oldest, Toughest Cells in the Heart (pages 157–176)

      Robert P. Thompson, Maria Reckova, Angela de Almeida, Michael R. Bigelow, Chiffvon P. Stanley, Joshua B. Spruill, Thomas T. Trusk and David Sedmera

    9. Transcriptional Regulation in the Mouse Atrioventricular Conduction System (pages 177–193)

      Angela V. Edwards, Dorene L. Davis, Amy L. Juraszek, Andy Wessels and John B. E. Burch

    10. Cardiac Conduction and Arrhythmia: Insights from Nkx2.5 Mutations in Mouse and Humans (pages 227–241)

      Patrick Y. Jay, Charles I. Berul, Makoto Tanaka, Masao Ishii, Yoshihisa Kurachi and Seigo Izumo

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    12. You have free access to this content