Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235

Copyright © Novartis Foundation 2001

Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235

Editor(s): Gregory Bock, Jamie A. Goode

Published Online: 7 OCT 2008

Print ISBN: 9780471494386

Online ISBN: 9780470868690

DOI: 10.1002/0470868694

Series Editor(s): Novartis Foundation

About this Book

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About The Product

With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders.

It contains contributions from leading experts in the field on topics such as:
age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue. For all those with an interest in the biology of ageing, this is compulsory reading.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–ix)

    2. Introduction (pages 1–3)

      Thomas B. L. Kirkwood

    3. The Priority of Basic Research on Ageing Vulnerability in a Comprehensive Research Agenda on Ageing for the 21st Century (pages 4–10)

      Gary R. Andrews

    4. Do Alterations in Glutathione and Iron Levels Contribute to Pathology Associated with Parkinson's Disease? (pages 11–25)

      Julie K. Andersen

    5. Specific Metal-Catalysed Protein Oxidation Reactions in Chronic Degenerative Disorders of Ageing: Focus on Alzheimer's Disease and Age-Related Cataracts (pages 26–43)

      Ashley I. Bush and Lee E. Goldstein

    6. General Discussion I (pages 44–48)

    7. Multiple Substrates of Late-Onset Dementia: Implications for Brain Protection (pages 49–65)

      R. N. Kalaria, C. G. Ballard, P. G. Ince, R. A. Kenny, I. G. McKeith, C. M. Morris, J. T. O'Brien, E. K. Perry, R. H. Perry and J. A. Edwardson

    8. Ageing of Murine Small Intestinal Stem Cells (pages 66–84)

      C. S. Potten, K. Martin and T. B. Kirkwood

    9. Haematopoietic Stem Cell Ageing (pages 85–100)

      Amiela Globerson

    10. General Discussion II (pages 101–104)

    11. Identification of Genes Involved in Cell Senescence and Immortalization: Potential Implications for Tissue Ageing (pages 105–115)

      James K. Leung and Olivia M. Pereira-Smith

    12. Ageing and Cancer: The Telomere and Telomerase Connection (pages 116–129)

      Jerry W. Shay and Woodring E. Wright

    13. Ageing and the Immune System (pages 130–145)

      Rita B. Effros

    14. General Discussion III (pages 146–149)

    15. Mechanisms of Age-Related Bone Loss (pages 150–171)

      Lis Mosekilde

    16. The Old Heart: Operating on the Edge (pages 172–201)

      Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe

    17. Pharmaceutical Intervention of Advanced Glycation Endproducts (pages 202–216)

      Anthony Cerami and Peter Ulrich

    18. General Discussion IV (pages 217–220)

    19. The Anti-Ageing Action of Dietary Restriction (pages 221–233)

      Holly Van Remmen, Zhongmao Guo and Arlan Richardson

    20. Mitochondrial DNA Mutations in Disease and Ageing (pages 234–246)

      D. A. Cottrell, E. L. Blakely, M. A. Johnson, G. M. Borthwick, P. I. Ince and D. M. Turnbull

    21. A Mitochondrial Paradigm for Degenerative Diseases and Ageing (pages 247–266)

      Douglas C. Wallace

    22. Final Discussion (pages 267–272)

    23. You have free access to this content
      Index of Contributors (pages 273–274)

    24. You have free access to this content
      Subject Index (pages 275–282)

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