The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity: Novartis Foundation Symposium 240

The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity: Novartis Foundation Symposium 240

Editor(s): Jamie A. Goode, Derek J. Chadwick

Published Online: 7 OCT 2008

Print ISBN: 9780471499596

Online ISBN: 9780470868713

DOI: 10.1002/0470868716

Series Editor(s): Novartis Foundation

About this Book

Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH?

It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy.  Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies. 

Table of contents

    1. You have free access to this content
    2. The Physiological Environment in Cancer Vascularization, Invasion and Metastasis (pages 23–45)

      Zaver M. Bhujwalla, Dmitri Artemov, Eric Aboagye, Ellen Ackerstaff, Robert J. Gillies, Kshama Natarajan and Meiyappan Solaiyappan

    3. Genomic Instability in Cancer (pages 133–151)

      Sara Rockwell, Jianling Yuan, Shani Peretz and Peter M. Glazer

    4. The HIF Pathway: Implications for Patterns of Gene Expression in Cancer (pages 212–231)

      Charles C. Wykoff, Christopher W. Pugh, Adrian L. Harris, Patrick H. Maxwell and Peter J. Ratcliffe

    5. ‘The Metabolism of Tumours’: 70 Years Later (pages 251–264)

      Gregg L. Semenza, Dmitri Artemov, Atul Bedi, Zaver Bhujwalla, Kelly Chiles, David Feldser, Erik Laughner, Rajani Ravi, Jonathan Simons, Panthea Taghavi and Hua Zhong

    6. You have free access to this content
    7. You have free access to this content

SEARCH