The Genetics and Biology of Sex Determination: Novartis Foundation Symposium 244

The Genetics and Biology of Sex Determination: Novartis Foundation Symposium 244

Editor(s): Derek Chadwick, Jamie Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470843468

Online ISBN: 9780470868737

DOI: 10.1002/0470868732

Series Editor(s): Novartis Foundation

About this Book

Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels.  A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. 

This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms.

By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.

Table of contents

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    2. Early Gonadal Development: Exploring Wt1 and Sox9 Function (pages 23–34)

      Jian-Kan Guo, Annette Hammes, Marie-Christine Chaboissier, Valerie Vidal, Yiming Xing, Frances Wong and Andreas Schedl

    3. Concerted Regulation of Gonad Differentiation by Transcription Factors and Growth Factors (pages 68–78)

      Taiga Suzuki, Hirofumi Mizusaki, Ken Kawabe, Megumi Kasahara, Hidefumi Yoshioka and Ken-Ichirou Morohashi

    4. Genetic Studies of MIS Signalling in Sexual Development (pages 157–168)

      Soazik P. Jamin, Nelson A. Arango, Yuji Mishina and Richard R. Behringer

    5. The Battle of the Sexes: Opposing Pathways in Sex Determination (pages 187–202)

      Humphrey Hung-Chang Yao, Christopher Tilmann, Guang-Quan Zhao and Blanche Capel

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