Ion Channels: From Atomic Resolution Physiology to Functional Genomics: Novartis Foundation Symposium 245

Copyright © Novartis Foundation 2002

Ion Channels: From Atomic Resolution Physiology to Functional Genomics: Novartis Foundation Symposium 245

Editor(s): Gregory Bock, Jamie A. Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470843758

Online ISBN: 9780470868751

DOI: 10.1002/0470868759

Series Editor(s): Novartis Foundation

About this Book

Product Information

About The Product

Ion channels provide a unique opportunity to use computational approaches to attempt an understanding of the function of a membrane protein, starting with an atomic resolution structure and progressing through a hierarchy of theoretical descriptions until one can account quantitatively for their physiological function. This book brings together physiologists, structural biologists and theorists who came together to help define the direction of the field in the immediate future.
Topics covered include:
* the x-ray structure of channels and pores
* computer simulation of channel function
* detailed data on potassium channels, chloride and calcium channels, and ligand-gated ion channels

Table of contents

    1. You have free access to this content
      Front Matter (pages i–ix)

    2. Introduction: Stretching the Envelope in Structure–Function Studies of Ion Channels (pages 1–4)

      Mark S. P. Sansom

    3. Structure of the Acetylcholine-Gated Channel (pages 5–21)

      Nigel Unwin

    4. The 2.7 Å Structure of AChBP, Homologue of the Ligand-Binding Domain of the Nicotinic Acetylcholine Receptor (pages 22–32)

      Katjuša Brejc, Willem J. van Dijk, August B. Smit and Titia K. Sixma

    5. The Architecture of a Water-Selective Pore in the Lipid Bilayer Visualized by Electron Crystallography in Vitreous Ice (pages 33–50)

      Alok K. Mitra, Gang Ren, Vijay S. Reddy, Anchi Cheng and Alexandrine Froger

    6. The Structure of G1pF, A Glycerol Conducting Channel (pages 51–65)

      Dax Fu, Andrew Libson and Robert Stroud

    7. Water in Ion Channels and Pores—Simulation Studies (pages 66–83)

      Mark S. P. Sansom, Peter Bond, Oliver Beckstein, Philip C. Biggin, José Faraldo-Gómez, Richard J. Law, George Patargias and D. Peter Tieleman

    8. What Can Be Deduced about the Structure of Shaker from Available Data? (pages 84–108)

      Benoit Roux

    9. Permeation Energetics in a Model Potassium Channel (pages 109–126)

      Stefano Garofoli, Gennady Miloshevsky, Vladimir L. Dorman and Peter C. Jordan

    10. The β Subunit of Kv1 Channels: Voltage-Gated Enzyme or Safety Switch? (pages 127–145)

      Jacqueline M. Gulbis

    11. EPR Approaches to Ion Channel Structure and Function (pages 146–164)

      E. Perozo, L. G. Cuello, D. M. Cortes, Y.-S. Liu and P. Sompornpisut

    12. General Discussion I (pages 165–168)

    13. Excitability is Mediated by the T1 Domain of the Voltage-Gated Potassium Channel (pages 169–177)

      Senyon Choe, Susan Cushman, Kent A. Baker and Paul Pfaffinger

    14. Structural Organization of the Voltage Sensor in Voltage-Dependent Potassium Channels (pages 178–192)

      Diane M. Papazian, William R. Silverman, Meng-chin A. Lin, Seema K. Tiwari-Woodruff and Chih-Yung Tang

    15. Electron Diffraction of a Bacterial ClC-Type Chloride Channel (pages 193–206)

      Michelle M. Pirruccello, Nikolaus Grigorieff and Joseph A. Mindell

    16. A Protein Chemical Approach to Channel Structure and Function: The Proton Channel of the Vacuolar H+-ATPase (pages 207–222)

      John B. C. Findlay and Michael A. Harrison

    17. Acetylcholine Receptors, Between Closed and Open (pages 223–239)

      Anthony Auerbach

    18. Functional Genomics of Ionotropic Acetylcholine Receptors in Caenorhabditis elegans and Drosophila melanogaster (pages 240–260)

      David B. Sattelle, Emmanuel Culetto, Marta Grauso, Valérie Raymond, Christopher J. Franks and Paula Towers

    19. Final General Discussion (pages 261–264)

    20. You have free access to this content
      Index of Contributors (pages 265–266)

    21. You have free access to this content
      Subject Index (pages 267–273)

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