Neuronal and Cognitive Effects of Oestrogens: Novartis Foundation Symposium 230

Copyright © Novartis Foundation 2000

Neuronal and Cognitive Effects of Oestrogens: Novartis Foundation Symposium 230

Editor(s): Derek J. Chadwick, Jamie A. Goode

Published Online: 29 APR 2008

Print ISBN: 9780471492030

Online ISBN: 9780470870815

DOI: 10.1002/0470870818

Series Editor(s): Novartis Foundation

About this Book

Product Information

About The Product

Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the survival, plasticity, regeneration and ageing of the mammalian brain.

This exciting book brings together leading clinicians and researchers to discuss oestrogen's basic mechanisms of action, the extrahypothalmic brain regions it affects, and its influence on cognitive functions in animals and humans. Finally, recent research on the role of oestrogens in ageing and dementia, including the significance of oestrogen action in Alzheimer's disease, is discussed. The 15 papers contained in this book, together with the extensive discussion sessions that follow them, reveal much new and exciting work in this area, and identify promising new research directions.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–ix)

    2. Chairman's Introduction (pages 1–6)

      Bruce McEwen

    3. Mechanism of Oestrogen Signalling with Particular Reference to the Role of ERβ in the Central Nervous System (pages 7–19)

      Eckardt Treuter, Margaret Warner and Jan-Åke Gustafsson

    4. Oestrogen Receptor Function at Classical and Alternative Response Elements (pages 20–32)

      Peter J. Kushner, David Agard, Wei-Jun Feng, Gabriela Lopez, Andrew Schiau, Rosalie Uht, Paul Webb and Geoffrey Greene

    5. General Discussion I (pages 33–40)

    6. Nuclear Receptor Versus Plasma Membrane Oestrogen Receptor (pages 41–55)

      Ellis R. Levin

    7. Novel Sites and Mechanisms of Oestrogen Action in the Brain (pages 56–73)

      C. Dominique Toran-Allerand

    8. Oestrogen Modulation of Noradrenaline Neurotransmission (pages 74–93)

      Allan E. Herbison, Sharon X. Simonian, Niren R. Thanky and R. John Bicknell

    9. Oestrogen and the Cholinergic Hypothesis: Implications for Oestrogen Replacement Therapy in Postmenopausal Women (pages 94–111)

      Robert B. Gibbs

    10. Ovarian Steroid Action in the Serotonin Neural System of Macaques (pages 112–133)

      Cynthia L. Bethea, Chrisana Gundlah and Stephanie J. Mirkes

    11. Oestrogen Effects on Dopaminergic Function in Striatum (pages 134–151)

      Jill B. Becker

    12. General Discussion II (pages 152–154)

    13. Oestrogen Effects in Olivo-Cerebellar and Hippocampal Circuits (pages 155–172)

      Sheryl S. Smith, Fu-Chun Hsu, Xinshe Li, Cheryl A. Frye, Donald S. Faber and Ronald S. Markowitz

    14. Effects of Oestradiol on Hippocampal Circuitry (pages 173–187)

      Catherine S. Woolley

    15. Oestrogen and Cognitive Function Throughout the Female Lifespan (pages 188–201)

      Barbara B. Sherwin

    16. Neuroprotective Effects of Phenolic A Ring Oestrogens (pages 202–220)

      Pattie S. Green, Shao-Hua Yang and James W. Simpkins

    17. The Female Sex Hormone Oestrogen as Neuroprotectant: Activities at Various Levels (pages 221–238)

      Christian Behl, Bernd Moosmann, Dieter Manthey and Stefanie Heck

    18. Neurohormonal Signalling Pathways and the Regulation oF Alzheimer β-Amyloid Metabolism (pages 239–253)

      Sam Gandy and Suzana Petanceska

    19. Oestrogens and Dementia (pages 254–273)

      Victor W. Henderson

    20. You have free access to this content
      Index of Contributors (pages 274–275)

    21. You have free access to this content
      Subject Index (pages 276–282)

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