Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231

Copyright © Novartis Foundation 2000

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231

Editor(s): Derek J. Chadwick, Jamie A. Goode

Published Online: 7 OCT 2008

Print ISBN: 9780471492467

Online ISBN: 9780470870839

DOI: 10.1002/0470870834

Series Editor(s): Novartis Foundation

About this Book

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About The Product

The field of neural transplantation is at a crucial stage, with  important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed.

This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–ix)

    2. Introduction (pages 1–6)

      Jeffrey Gray

    3. Cell Replacement Strategies for Neurodegenerative Disorders (pages 7–20)

      Anders Björklund

    4. Functional Analysis of Fronto–Striatal Reconstruction by Striatal Grafts (pages 21–52)

      Stephen B. Dunnett

    5. Functional Reconstruction of the Hippocampus: Fetal Versus Conditionally Immortal Neuroepithelial Stem Cell Grafts (pages 53–69)

      H. Hodges, P. Sowinski, D. Virley, A. Nelson, T. R. Kershaw, W. P. Watson, T. Veizovic, S. Patel, A. Mora, T. Rashid, S. J. French, A. Chadwick, J. A. Gray and J. D. Sinden

    6. Gene Transfer for Neuroprotection in Animal Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis (pages 70–93)

      Martha C. Bohn, Bronwen Connor, Dorothy A. Kozlowski and M. Hasan Mohajeri

    7. Repair of Corticospinal Axons by Transplantation of Olfactory Ensheathing Cells (pages 94–109)

      Geoff Raisman

    8. Neural Transplantation in Parkinson's Disease (pages 110–128)

      Olle Lindvall

    9. Transplantation of Human Fetal Striatal Tissue in Huntington's Disease: Rationale for Clinical Studies (pages 129–144)

      Thomas B. Freeman, Robert A. Hauser, Alison E. Willing, Tanja Zigova, Paul R. Sanberg and Samuel Saporta

    10. General Discussion I (pages 145–147)

    11. Neurotransplantation in Neurodegenerative Disease: A Survey of Relevant Issues in Developmental Neurobiology (pages 148–165)

      Jack Price, Dafe Uwangho, Scott Peters, Diane Galloway and Karen Mellodew

    12. Molecular and Cellular Mechanisms in Immune Rejection of Intracerebral Neural Transplants (pages 166–183)

      Thomas Brevig, Erik Bo Pedersen and Bente Finsen

    13. Porcine Neural Xenografts: What Are the Issues? (pages 184–201)

      Roger A. Barker

    14. Gene Transfer Techniques for the Delivery of GDNF in Parkinson's Disease (pages 202–219)

      Jean-Luc Ridet, Nicole Déglon and Patrick Aebischer

    15. Neurogenesis in the Adult Hippocampus (pages 220–241)

      Gerd Kempermann and Fred H. Gage

    16. Neural Stem Cells Are Uniquely Suited for Cell Replacement and Gene Therapy in the CNS (pages 242–269)

      Vaclav Ourednik, Jitka Ourednik, Kook I. Park, Y. D. Teng, Karen A. Aboody, Kurtis I. Auguste, Rosanne M. Taylor, Barbara A. Tate and Evan Y. Snyder

    17. Functional Repair with Neural Stem Cells (pages 270–288)

      John D. Sinden, Paul Stroemer, Gregory Grigoryan, Sara Patel, Sarah J. French and Helen Hodges

    18. Remyelinating the Demyelinated CNS (pages 289–301)

      W. F. Blakemore, P. M. Smith and R. J. M. Franklin

    19. General Discussion II (pages 302–306)

    20. Final Discussion (pages 307–314)

    21. You have free access to this content
      Index of Contributors (pages 315–316)

    22. You have free access to this content
      Subject Index (pages 317–323)

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