Current Protocols in Toxicology
Online ISBN: 9780471140856
DOI: 10.1002/0471140856
Archive
Current Protocols in Toxicology Supplements
2012: Supplement 52 Supplement 51
2011: Supplement 50 Supplement 49 Supplement 48 Supplement 47
2010: Supplement 46 Supplement 45 Supplement 44 Supplement 43
2009: Supplement 42 Supplement 41 Supplement 40 Supplement 39
2008: Supplement 38 Supplement 37 Supplement 36 Supplement 35
2007: Supplement 34 Supplement 33 Supplement 32 Supplement 31
2006: Supplement 30 Supplement 29 Supplement 28 Supplement 27
2005: Supplement 26 Supplement 25 Supplement 24 Supplement 23
2004: Supplement 22 Supplement 21 Supplement 20 Supplement 19
2003: Supplement 18 Supplement 17 Supplement 16 Supplement 15
2002: Supplement 14 Supplement 13 Supplement 12 Supplement 11
2001: Supplement 10 Supplement 9 Supplement 8 Supplement 7
2000: Supplement 6 Supplement 5 Supplement 4 Supplement 3
1999: Supplement 2 Supplement 1 Core publication
Supplement 52, May 2012
Unit 11.16 Morphological Assessment of Neurite Outgrowth in Hippocampal Neuron-Astrocyte Co-Cultures
Abstract | Full Text: HTML PDF
Unit 23.1 Measuring Altered Disposition of Xenobiotics in Experimental Models of Liver Disease
Abstract | Full Text: HTML PDF
Unit 23.2 Use of Zinc Finger Nuclease Technology to Knock Out Efflux Transporters in C2BBe1 Cells
Abstract | Full Text: HTML PDF
Supplement 51, February 2012
Unit 4.38 CYP1B1 Detection
Abstract | Full Text: HTML PDF
Unit 17.15 High-Throughput, Multiplexed Analysis of 3-Nitrotyrosine in Individual Proteins
Abstract | Full Text: HTML PDF
Unit 18.15 Developmental Immunotoxicity (DIT): Assays for Evaluating Effects of Exogenous Agents on Development of the Immune System
Abstract | Full Text: HTML PDF
Unit 20.7 The Local Lymph Node Assay (LLNA)
Abstract | Full Text: HTML PDF
Supplement 50, November 2011
Unit 2.22 Murine Embryonic Stem Cell Derivation, In Vitro Pluripotency Characterization, and In Vivo Teratoma Formation
Abstract | Full Text: HTML PDF
Unit 12.19 Methods to Assess Neuroinflammation
Abstract | Full Text: HTML PDF
Unit 22.3 Preparation of Epithelial and Mesenchymal Stem Cells from Murine Mammary Gland
Abstract | Full Text: HTML PDF
Supplement 49, August 2011
Unit 2.20 Assessment of Mitochondrial Toxicity in HepG2 Cells in Cultured in High-Glucose- or Galactose-Containing Media
Abstract | Full Text: HTML PDF
Unit 2.21 Measuring Intracellular hsp70 in Leukocytes by Flow Cytometry
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Unit 7.9 Overview of Peroxiredoxins in Oxidant Defense and Redox Regulation
Abstract | Full Text: HTML PDF
Unit 7.10 Measurement of Peroxiredoxin Activity
Abstract | Full Text: HTML PDF
Supplement 48, May 2011
Unit 2.19 Fluorescence Correlation Spectroscopy: Detecting and Interpreting the Mobility of Transmembrane Proteins In Vivo
Abstract | Full Text: HTML PDF
Unit 3.11 High-Throughput Assays for Assessing Mitochondrial Dysfunction Caused by Compounds that Impair mtDNA-Encoded Protein Levels in Eukaryotic Cells
Abstract | Full Text: HTML PDF
Unit 4.37 Aldehyde Reduction by Cytochrome P450
Abstract | Full Text: HTML PDF
Unit 12.18 Cellular fura-2 Manganese Extraction Assay (CFMEA)
Abstract | Full Text: HTML PDF
Supplement 47, February 2011
Unit 2.18 Role Integrative Signaling Through Gap Junctions in Toxicology
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Unit 20.6 Caco-2 Cells as a Model for Intestinal Absorption
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Unit 22.1 Using Chemotherapeutic Drugs to Trigger Hematopoietic Stem Cell Activation and Determine Hematological Toxicity
Abstract | Full Text: HTML PDF
Unit 22.2 Isolation and Applications of Prostate Side Population Cells Based on Dye Cycle Violet Efflux
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Supplement 46, November 2010
Unit 12.16 Morphometric Analysis in Neurodegenerative Disorders
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Unit 21.8 Assessment of Gastrointestinal Motility Using Three Different Assays In Vitro
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Unit 21.9 Assessment of Gastrointestinal Propulsive Activity Using Three Different Models of Peristalsis In Vivo in the Mouse
Abstract | Full Text: HTML PDF
Supplement 45, August 2010
Unit 17.13 Transcription Factor Nrf2: Examination of Nuclear Protein Levels by Immunoblotting and Promoter Response Element Binding by Chromatin Immunoprecipitation (ChIP)
Abstract | Full Text: HTML PDF
Unit 17.14 LC-MS/MS Quantitation of Mercapturic Acid Conjugates of Lipid Peroxidation Products as Markers of Oxidative Stress
Abstract | Full Text: HTML PDF
Unit 21.5 Measurement of Gastric Acid Secretion in the Anaesthetized Rat
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Unit 21.6 Endogenous Gastric Mediators: Patho-Physiological Role and Measurements
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Unit 21.7 Measurement of Small Intestinal Damage
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Supplement 44, May 2010
Unit 4.36 Measurement of Cysteine S-Conjugate β-Lyase Activity
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Unit 14.8 Assessment of Mitochondrial Dysfunction Arising from Treatment with Hepatotoxicants
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Unit 21.3 Assessment of Enteral Bacteria
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Unit 21.4 Assessment of Ischemic Vascular Damage
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Supplement 43, February 2010
Unit 4.35 Manipulation of Expression of Arsenic (+3 Oxidation State) Methyltransferase in Cultured Cells
Abstract | Full Text: HTML PDF
Unit 12.16 Morphometric Analysis in Neurodegenerative Disorders
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Unit 12.17 Neonatal Rat Primary Microglia: Isolation, Culturing, and Selected Applications
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Unit 21.1 Overview of Gastrointestinal Toxicology
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Unit 21.2 Methods to Measure Gastric Mucosal Lesions in the Rat
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Supplement 42, November 2009
Unit 4.30 Co-Oxidation by Cyclooxygenases
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Unit 4.31 An Overview of Arsenic Metabolism and Toxicity
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Unit 4.32 In Vitro Assays of Inorganic Arsenic Methylation
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Unit 4.33 Analysis of Arsenical Metabolites in Biological Samples
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Unit 4.34 Purification of Arsenic (+3 Oxidation State) Methyltransferase from Rat Liver Cytosol
Abstract | Full Text: HTML PDF
Unit 12.15 Application of Single-Cell Microfluorimetry to Neurotoxicology Assays
Abstract | Full Text: HTML PDF
Supplement 41, August 2009
Unit 2.17 Assessment of Gap Junctional Intercellular Communication
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Unit 4.28 Azoreductase in Staphylococcus aureus
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Unit 4.29 Measurement of Phenylalanine Monooxygenase (PAH) Activities
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Unit 5.8 Determination of ADME and Bioavailability Following Intravenous, Oral, and Dermal Routes of Exposure
Abstract | Full Text: HTML PDF
Unit 17.12 Thioredoxin Redox Western Analysis
Abstract | Full Text: HTML PDF
Supplement 40, May 2009
Unit 2.15 Current Concepts in Drug-Induced Mitochondrial Toxicity
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Unit 2.16 Fluoroscent pH and Oxygen Probes of the Assessment of Mitochondrial Toxicity in Isolated Mitochondria and Whole Cells
Abstract | Full Text: HTML PDF
Unit 17.11 Measuring Electrophile Stress
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Supplement 39, February 2009
Unit 1.10 Use of Medaka in Toxicity Testing
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Unit 4.27 Measurement of In Vitro Cytochrome P450 2B6 Activity
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Unit 6.16 Glutamate Cysteine Ligase (GCL) Transgenic and Gene-Targeted Mice for Controlling Glutathione Synthesis
Abstract | Full Text: HTML PDF
Unit 12.14 Measurement of Isoprostanes as Markers of Oxidative Stress in Neuronal Tissue
Abstract | Full Text: HTML PDF
Supplement 38, November 2008
Unit 4.26 Assays for S-Adenosylmethionine (AdoMet/SAM)-Dependent Methyltransferases
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Unit 6.15 Measurement of Cysteine Dioxygenase Activity and Protein Abundance
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Unit 17.2 Measurement of Protein Sulfenic Acid Content
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Unit 17.10 Complex I Assay in Mitochondrial Preparations from CNS
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Supplement 37, August 2008
Unit 14.7 A Rat Primary Hepatocyte Culture Model for Aging Studies
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Unit 20.5 CFU-MK Assay for Acute Thrombocytopenia
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Appendix 1A Safe Use of Radioisotopes
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Appendix 1C Radioactivity
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Supplement 36, May 2008
Unit 2.14 Cross-Species Genetic Toxicity Assessment Accomplished by Flow Cytometric Analysis of Blood
Abstract | Full Text: HTML PDF
Unit 18.14 Analysis of Modulation of Immunoglobulin Gene Expression
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Unit 20.4 Neutral Red Uptake Cytotoxicity Tests for Estimating Starting Doses for Acute Oral Toxicity Tests
Abstract | Full Text: HTML PDF
Supplement 35, February 2008
Unit 6.14 Measurement of Aminoacylases
Abstract | Full Text: HTML PDF
Unit 11.15 Experimental Models of Hypoxic-Ischemic Encephalopathy: Hypoxia-Ischemia in the Immature Rat
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Unit 17.9 Identification and Characterization of Oxylipid-Protein and Peptide Conjugates by Mass Spectrometry
Abstract | Full Text: HTML PDF
Unit 20.3 The Syrian Hamster Embryo (SHE) Low pH Cell Transformation Assay
Abstract | Full Text: HTML PDF
Supplement 34, November 2007
Unit 6.12 Glutathione-Dependent Bioactivation
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Unit 6.13 Methods for Measuring Cysteine S -Conjugate β-Lyase Activity
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Unit 12.13 Determination of Cholinesterase in Blood and Tissue
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Unit 20.1 Overview of Alternative Methodologies in Toxicology
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Unit 20.2 CFU-GM Assay for Evaluation of Drug Myelotoxic Activity
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Supplement 33, August 2007
Unit 4.23 Measurement of Soluble Epoxide Hydrolase (sEH) Activity
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Unit 4.24 Enzymatic Activity of Human Carboxylesterases
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Unit 4.25 In Vitro Evaluation of Metabolic Drug-Drug Interactions: A Descriptive and Critical Commentary
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Unit 18.13 Fluorescence Microscopy and Flow Cytometric Analysis of Peyer's Patches and Intestinal Immune Cells
Abstract | Full Text: HTML PDF
Appendix 3B Techniques for Mammalian Cell Tissue Culture
Abstract | Full Text: HTML PDF
Supplement 32, May 2007
Unit 4.22 Biochemical and Genetic Analysis of NAD(P)H:Quinone Oxidoreductase 1 (NQO1)
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Unit 14.6 Measuring Covalent Binding in Hepatotoxicity
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Appendix 3F One-Dimensional SDS Gel Electrophoresis of Proteins
Abstract | Full Text: HTML PDF
Supplement 31, February 2007
Unit 1.9 The Nematode C. elegans as an Animal Model to Explore Toxicology In Vivo: Solid and Axenic Growth Culture Conditions and Compound Exposure Parameters
Abstract | Full Text: HTML PDF
Unit 2.13 Mouse Models for Human Hemato-Lymphopoiesis
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Unit 19.1 Toxicology Testing in Drug Discovery and Development
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Unit 19.2 Toxicity Testing in Chemical Safety Evaluation
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Supplement 30, November 2006
Unit 2.12 Detection of the Mitochondrial Apoptosis-Induced Channel (MAC) and Its Regulation by Bcl-2 Family Proteins
Abstract | Full Text: HTML PDF
Unit 4.21 Monoamine Oxidase Assays
Abstract | Full Text: HTML PDF
Unit 13.12 Analysis of Ultrasonic Vocalizations Emitted by Infant Rodents
Abstract | Full Text: HTML PDF
Supplement 29, August 2006
Unit 4.20 NMR Analysis of Thiodiglycol Oxidation by Mammalian Alcohol Dehydrogenases
Abstract | Full Text: HTML PDF
Unit 7.8 Measurement of the Vitamin E Metabolites, Carboxyethyl Hydroxychromans (CEHCs), in Biological Samples
Abstract | Full Text: HTML PDF
Unit 18.11 Analysis of Immunotoxicity by Enumeration of Antibody-Producing B Cells
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Unit 18.12 The Reporter Antigen Popliteal Lymph Node Assay
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Supplement 28, May 2006
Unit 3.10 Analysis of Mismatch Repair in Human Nuclear Extracts
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Unit 6.10 Overview of Protein Glutathionylation
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Unit 6.11 Measurement of Protein Glutathionylation
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Unit 17.8 Detection of Stress Proteins as Biomarkers of Oxidative Stress
Abstract | Full Text: HTML PDF
Supplement 27, February 2006
Unit 2.11 Single-Cell Analysis of Lipid Rafts in Lymphocytes and in T Cell–Containing Immunoconjugates
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Unit 4.19 Measurement of Human Cytochrome P4501A2 ( CYP1A2 ) Activity In Vitro
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Unit 7.7 Catalase Activity Assays
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Unit 13.11 Scoring Learning and Memory in Developing Rodents
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Unit 18.10 Host Resistance Model to an Intracellular Pathogen
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Supplement 26, November 2005
Unit 4.18 Aldehyde Dehydrogenases: Measurement of Activities and Protein Levels
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Unit 13.9 Methods in the Analysis of Maternal Behavior in the Rodent
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Unit 13.10 Scoring of Social Interactions and Play in Mice During Adolescence
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Unit 16.9 Hershberger Assay to Investigate the Effects of Endocrine-Disrupting Compounds with Androgenic or Antiandrogenic Activity in Castrate-Immature Male Rats
Abstract | Full Text: HTML PDF
Supplement 25, August 2005
Unit 4.17 Measurement of Xenobiotic Carbonyl Reduction in Human Liver Fractions
Abstract | Full Text: HTML PDF
Unit 13.7 Overview of Behavioral Teratology
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Unit 13.8 Statistical Analysis of Behavioral Data
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Supplement 24, May 2005
Unit 4.16 Evaluation of the Cytochrome b 5 /Cytochrome b 5 Reductase Pathway
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Unit 17.5 F 2 -Isoprostanes as Markers of Oxidant Stress: An Overview
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Unit 17.6 Quantification of F 2 -Isoprostanes by Gas Chromatography/Mass Spectrometry as a Measure of Oxidant Stress
Abstract | Full Text: HTML PDF
Unit 17.7 Immuno-Spin Trapping: Detection of Protein-Centered Radicals
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Unit 18.9 In Vitro Model for Modulation of Helper T Cell Differentiation and Activation
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Supplement 23, February 2005
Unit 11.14 Methods to Produce Brain Hyperthermia
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Unit 18.7 Solid-Phase Immunoassays
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Unit 18.8 Immune Cell Phenotyping Using Flow Cytometry
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Appendix 3I The Colorimetric Detection and Quantitation of Total Protein
Abstract | Full Text: HTML PDF
Supplement 22, November 2004
Unit 4.15 TaqMan Real Time–Polymerase Chain Reaction Methods for Determination of Nucleotide Polymorphisms in Human N -Acetyltransferase-1 ( NAT1 ) and -2 ( NAT2 )
Abstract | Full Text: HTML PDF
Unit 5.7 Collection of Bile and Urine Samples for Determining the Urinary and Hepatobiliary Disposition of Xenobiotics in Mice
Abstract | Full Text: HTML PDF
Unit 11.13 Detection and Assessment of Xenobiotic-Induced Sensory Neuropathy
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Unit 12.12 Morphological Measurement of Neurotoxic Injury in the Peripheral Nervous System: Preparation of Material for Light and Transmission Electron Microscopic Evaluation
Abstract | Full Text: HTML PDF
Unit 18.5 Measuring Lymphocyte Transcription Factor Activity by ELISA
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Unit 18.6 Measuring the Activity of Cytolytic Lymphocytes
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Supplement 21, August 2004
Unit 4.14 Biotransformation Studies Using Rat Proximal Tubule Cells
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Unit 18.3 Murine Asthma Models
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Unit 18.4 Use of Bronchoalveolar Lavage to Detect Lung Injury
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Appendix 3G Spectrophotometric Determination of Protein Concentration
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Supplement 20, May 2004
Unit 4.13 Human Cytochrome P450: Metabolism of Testosterone by CYP3A4 and Inhibition by Ketoconazole
Abstract | Full Text: HTML PDF
Unit 17.4 In Situ Localization of Nonenzymatic Peroxidase-Like Activity of Tissue-Bound Transition Metals
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Unit 18.1 Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment
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Unit 18.2 Local Lymph Node Assays
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Supplement 19, February 2004
Unit 2.10 Analysis of Mitochondrial Dysfunction During Cell Death
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Unit 4.12 Determination of Paraoxonase 1 Status and Genotypes at Specific Polymorphic Sites
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Unit 14.5 Measurement of Hepatobiliary Transport
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Unit 16.8 Transgenerational (In Utero/Lactational) Exposure to Investigate the Effects of Endocrine Disrupting Compounds (EDCs) in Rats
Abstract | Full Text: HTML PDF
Supplement 18, November 2003
Unit 1.8 Preclinical Models of Parkinson's Disease
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Unit 12.11 Determining the Ability of Xenobiotic Metals to Bind a Specific Protein Domain by Electrophoresis
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Unit 17.1 Formation and Functions of Protein Sulfenic Acids
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Unit 17.2 Measurement of Protein Sulfenic Acid Content
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Unit 17.3 Fluorescence Microplate Reader Measurement of Tissue Susceptibility to Lipid Peroxidation
Abstract | Full Text: HTML PDF
Supplement 17, August 2003
Unit 1.7 Zebrafish: An Animal Model for Toxicological Studies
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Unit 11.10 Principles of Electrophysiology: An Overview
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Unit 11.11 Electrophysiological Studies of Neurotoxicants on Central Synaptic Transmission in Acutely Isolated Brain Slices
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Unit 11.12 Whole-Cell Patch-Clamp Electrophysiology of Voltage-Sensitive Channels
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Supplement 16, May 2003
Unit 1.6 Sea Urchin Embryos and Larvae as Biosensors for Neurotoxicants
Abstract | Full Text: HTML PDF
Unit 13.5 In Vivo Assessment of Prenatal Developmental Toxicity in Rodents
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Unit 13.6 Organ Culture of Midfacial Tissue and Secondary Palate
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Unit 16.7 Performing a Testicular Spermatid Head Count
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Supplement 15, February 2003
Unit 1.5 The Use of Fish-Derived Cell Lines for Investigation of Environmental Contaminants
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Unit 5.6 Toxicant Transport by P-Glycoprotein
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Unit 6.9 Coenzyme A and Coenzyme A-Glutathione Mixed Disulfide Measurements by HPLC
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Unit 9.9 Purification and Characterization of Heme Oxygenase
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Unit 12.9 Aggregating Neural Cell Cultures
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Unit 12.10 Coculturing Neurons and Glial Cells
Abstract | Full Text: HTML PDF
Supplement 14, November 2002
Unit 4.11 Techniques for Measuring the Activity of Carboxylic Acid:CoA Ligase and Acyl-CoA:Amino Acid N -Acyltransferase: The Amino Acid Conjugation Pathway
Abstract | Full Text: HTML PDF
Unit 6.8 Measurement of Glutathione Conjugates
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Unit 13.4 Using Chicken Embryos for Teratology Studies
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Unit 14.4 Isolation of Liver Kupffer Cells
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Unit 16.6 Epididymal Sperm Count
Abstract | Full Text: HTML PDF
Supplement 13, August 2002
Unit 4.9 Measurements of Flavin-Containing Monooxygenase (FMO) Activities
Abstract | Full Text: HTML PDF
Unit 4.10 Assays for the Classification of Two Types of Esterases: Carboxylic Ester Hydrolases and Phosphoric Triester Hydrolases
Abstract | Full Text: HTML PDF
Unit 16.4 Histopathology of the Male Reproductive System II: Interpretation
Abstract | Full Text: HTML PDF
Unit 16.5 Monitoring Endocrine Function in Males: Using Intra-Atrial Cannulas to Monitor Plasma Hormonal Dynamics in Toxicology Experiments
Abstract | Full Text: HTML PDF
Supplement 12, May 2002
Unit 3.8 Methods for Measuring DNA Adducts and Abasic Sites I: Isolation, Purification, and Analysis of DNA Adducts in Intact DNA
Abstract | Full Text: HTML PDF
Unit 3.9 Methods for Measuring DNA Adducts and Abasic Sites II: Methods for Measurement of DNA Adducts
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Unit 7.6 Measurement of Ascorbic Acid and Dehydroascorbic Acid in Biological Samples
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Unit 9.8 Quantitation of Human Heme Oxygenase (HO-1) Copies by Competitive RT-PCR
Abstract | Full Text: HTML PDF
Unit 16.3 Histopathology of the Male Reproductive System I: Techniques
Abstract | Full Text: HTML PDF
Supplement 11, February 2002
Unit 4.8 Analysis of the Aryl Hydrocarbon Receptor (AhR) Signal Transduction Pathway
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Unit 12.8 Measurement of Glial Fibrillary Acidic Protein
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Unit 14.3 Small Animal Models of Hemorrhagic Shock–Induced Liver Dysfunction
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Unit 16.1 In Vivo Models for Male Reproductive Toxicology
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Unit 16.2 Guidelines for Mating Rodents
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Supplement 10, November 2001
Unit 4.6 Measuring the Activity of Arylamine N -Acetyltransferase (NAT)
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Unit 4.7 Measurement of Carboxylesterase (CES) Activities
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Unit 15.3 Aggregation Chimeras (ES Cell–Embryo)
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Unit 15.4 Reporter Genes to Detect Cre Excision in Mice
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Appendix 3G Spectrophotometric and Colorimetric Determination of Protein Concentration
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Appendix 3H Dialysis and Concentration of Protein Solutions
Abstract | Full Text: HTML PDF
Supplement 9, August 2001
Unit 1.4 DNA Microarrays: An Overview of Technologies and Applications to Toxicology
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Unit 5.5 Porcine Skin Flow-Through Diffusion Cell System
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Unit 12.7 Isolation of Cerebellar Granule Cells from Neonatal Rats
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Unit 15.1 Embryonic Stem (ES) Cell Culture Basics
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Unit 15.2 Genotyping Embryonic Stem (ES) Cells
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Appendix 3F One-Dimensional SDS Gel Electrophoresis of Proteins
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Supplement 8, May 2001
Unit 4.5 Measurement of Aryl and Alcohol Sulfotransferase Activity
Abstract | Full Text: HTML PDF
Unit 5.4 Isolated Perfused Porcine Skin Flap
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Unit 6.7 Oxidant-Induced Regulation of Glutathione Synthesis
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Unit 7.5 Measurement of MnSOD and CuZnSOD Activity in Mammalian Tissue Homogenates
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Unit 14.1 Overview of Hepatotoxicity
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Unit 14.2 Preparation of Hepatocytes
Abstract | Full Text: HTML PDF
Supplement 7, February 2001
Unit 2.9 Measurement of Expression of the HSP70 Protein Family
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Unit 8.9 HPLC Methods for Analysis of Porphyrins in Biological Media
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Unit 13.3 Micromass Cultures in Teratology
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Appendix 3D Detection and Quantitation of Radiolabeled Proteins in Gels and Blots
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Appendix 3E Northern Blot Analysis of RNA
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Supplement 6, November 2000
Unit 9.7 Functional Analysis of the Heme Oxygenase-1 Gene Promoter
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Unit 11.9 Mouse Models of Focal Cerebral Ischemia
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Unit 12.6 Estimating Cell Number in the Central Nervous System by Stereological Methods: The Optical Disector and Fractionator
Abstract | Full Text: HTML PDF
Unit 13.1 Overview of Teratology
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Unit 13.2 Rat Embryo Cultures for In Vitro Teratology
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Supplement 5, August 2000
Unit 2.7 In Situ Hybridization Histochemistry
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Unit 2.8 Confocal Microscopy
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Unit 6.6 γ-Glutamyl Transpeptidase Activity Assay
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Unit 7.4 Measurement of Thioredoxin and Thioredoxin Reductase
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Unit 9.6 An HPLC Method to Detect Heme Oxygenase Activity
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Unit 11.8 Mouse Models of Global Cerebral Ischemia
Abstract | Full Text: HTML PDF
Supplement 4, May 2000
Unit 5.3 Measurement of Disposition Half-Life, Clearance, and Residence Times
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Unit 10.9 Inducible Nitric Oxide Synthase Expression
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Unit 12.3 Culturing Rat Hippocampal Neurons
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Unit 12.4 Isolation of Neonatal Rat Cortical Astrocytes for Primary Cultures
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Unit 12.5 Analytical Cytology: Applications to Neurotoxicology
Abstract | Full Text: HTML PDF
Supplement 3, February 2000
Unit 2.6 In Vitro Methods for Detecting Cytotoxicity
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Unit 3.6 Detecting Epigenetic Changes: DNA Methylation
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Unit 3.7 Assays for Detecting Chromosomal Aberrations
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Unit 4.4 Detection of Metabolites Using High-Performance Liquid Chromatography and Mass Spectrometry
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Unit 10.8 Methods for Distinguishing Nitrosative and Oxidative Chemistry of Reactive Nitrogen Oxide Species Derived from Nitric Oxide
Abstract | Full Text: HTML PDF
Unit 12.1 Biochemical Approaches to Studying Neurotoxicity
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Unit 12.2 Development of an In Vitro Blood-Brain Barrier
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Appendix 3C Enzymatic Amplification of DNA by PCR: Standard Procedures and Optimization
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Supplement 2, November 1999
Unit 3.5 Assays for DNA Damage
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Unit 8.7 Measurement of Ferrochelatase Activity
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Unit 8.8 Measurement of Erythrocyte Protoporphyrin Concentration by Double Extraction and Spectrofluorometry
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Unit 10.7 Immunocytochemical Analysis of Cyclic Nucleotides
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Unit 11.6 Risk Assessment and Neurotoxicology
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Unit 11.7 Neurobehavioral Testing in Humans
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Appendix 3B Techniques for Mammalian Cell Tissue Culture
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Supplement 1, August 1999
Unit 2.5 Measurements of Intracellular Free Calcium Concentration in Biological Systems
Abstract | Full Text: HTML PDF
Unit 3.3 Mutagenesis Assays in Mammalian Cells
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Unit 3.4 Cell Transformation Assays
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Unit 8.6 Measurement of δ-Aminolevulinate Dehydratase Activity
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Unit 9.5 Histochemical Analysis of Heme Degradation Enzymes
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Unit 10.6 Histochemical Analysis of Nitric Oxide Synthase by NADPH Diaphorase Staining
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Appendix 1B Transgenic and Gene-Targeted Mouse Lines for Toxicology Studies
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Core Publication, May 1999
Unit 1.1 Nonhuman Primates as Animal Models for Toxicology Research
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Unit 1.2 Statistical Approaches to the Design of Toxicology Studies
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Unit 1.3 Transgenic Animals in Toxicology
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Unit 2.1 Current Concepts in Cell Toxicity
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Unit 2.2 Determination of Apoptosis and Necrosis
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Unit 2.3 Detection of Covalent Binding
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Unit 2.4 Measurement of Lipid Peroxidation
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Unit 3.1 The Salmonella (Ames) Test for Mutagenicity
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Unit 3.2 Measurement of a Malondialdehyde-DNA Adduct
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Unit 4.1 Measurement of Cytochrome P-450
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Unit 4.2 Purification of Cytochrome P-450 Enzymes
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Unit 4.3 Measurements of UDP- Glucuronosyltransferase (UGT) Activities
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Unit 5.1 Measurement of Bioavailability: Measurement of Absorption Through Skin In Vitro
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Unit 5.2 Measurement of Bioavailability: Measuring Absorption Through Skin In Vivo in Rats and Humans
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Unit 6.1 Overview of Glutathione Function and Metabolism
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Unit 6.2 Measurement of Glutathione and Glutathione Disulfide
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Unit 6.3 Measurement of Glutathione Transport
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Unit 6.4 Measurement of Glutathione Transferases
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Unit 6.5 HPLC-Based Assays for Enzymes of Glutathione Biosynthesis
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Unit 7.1 Analysis of Glutathione-Related Enzymes
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Unit 7.2 Measurement of Glutathione Reductase Activity
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Unit 7.3 Analysis of Superoxide Dismutase Activity
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Unit 8.1 The Heme Biosynthesis Pathway and Clinical Manifestations of Abnormal Function
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Unit 8.2 Measurement of ALA Synthase Activity
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Unit 8.3 Measurement of Heme Concentration
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Unit 8.4 Measurement of Uroporphyrinogen Decarboxylase Activity
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Unit 8.5 Measurement of Protoporphyrinogen Oxidase Activity
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Unit 9.1 Overview of Heme Degradation Pathway
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Unit 9.2 Detection of Heme Oxygenase Activity by Measurement of CO
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Unit 9.3 Detection of Heme Oxygenase 1 and 2 Proteins and Bilirubin Formation
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Unit 9.4 Detection of Biliverdin Reductase Activity
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Unit 10.1 Overview of the Pathway and Functions of Nitric Oxide
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Unit 10.2 Assay of Tissue Activity of Nitric Oxide Synthase
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Unit 10.3 Detection of Nitrosated Proteins
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Unit 10.4 Fluorometric Techniques for the Detection of Nitric Oxide and Metabolites
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Unit 10.5 Measurement of cGMP and Soluble Guanylyl Cyclase Activity
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Unit 11.1 Overview of Neurotoxicology
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Unit 11.2 Neurobehavioral Screening in Rodents
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Unit 11.3 Assessment of Spatial Memory
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Unit 11.4 Advanced Behavioral Testing in Rodents: Assessment of Cognitive Function in Animals
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Unit 11.5 Testing for Organophosphate-Induced Delayed Polyneuropathy
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Appendix 1A Safe Use of Radioisotopes
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Appendix 2A Common Stock Solutions and Buffers
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Appendix 2B Standard Laboratory Equipment
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Appendix 3A Molecular Biology Techniques
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