Current Protocols in Toxicology

Current Protocols in Toxicology

Online ISBN: 9780471140856

DOI: 10.1002/0471140856

Archive


 

Current Protocols in Toxicology Supplements

2017:    Supplement 72     Supplement 71    
2016:    Supplement 70     Supplement 69     Supplement 68     Supplement 67    
2015:    Supplement 66     Supplement 65     Supplement 64     Supplement 63
2014:    Supplement 62     Supplement 61     Supplement 60     Supplement 59    
2013:    Supplement 58     Supplement 57     Supplement 56     Supplement 55    
2012:    Supplement 54     Supplement 53     Supplement 52     Supplement 51    
2011:    Supplement 50     Supplement 49     Supplement 48     Supplement 47    
2010:    Supplement 46     Supplement 45     Supplement 44     Supplement 43    
2009:    Supplement 42     Supplement 41     Supplement 40     Supplement 39    
2008:    Supplement 38     Supplement 37     Supplement 36     Supplement 35    
2007:    Supplement 34     Supplement 33     Supplement 32     Supplement 31    
2006:    Supplement 30     Supplement 29     Supplement 28     Supplement 27    
2005:    Supplement 26     Supplement 25     Supplement 24     Supplement 23    
2004:    Supplement 22     Supplement 21     Supplement 20     Supplement 19    
2003:    Supplement 18     Supplement 17     Supplement 16     Supplement 15    
2002:    Supplement 14     Supplement 13     Supplement 12     Supplement 11    
2001:    Supplement 10     Supplement 9       Supplement 8       Supplement 7      
2000:    Supplement 6       Supplement 5       Supplement 4       Supplement 3      
1999:    Supplement 2       Supplement 1       Core publication


If you are unable to find the unit you require, please contact Customer Service for assistance.



If you are unable to find the unit you require, please contact Customer Service for assistance.



 Supplement 72, May 2017

Unit 2.26 Quantification of Lactate Dehydrogenase for Cell Viability Testing Using Cell Lines and Primary Cultured Astrocytes
         Abstract | Full Text:  HTML   PDF

Unit 3.14 Using Chromatin Immunoprecipitation in Toxicology: A Step-by-Step Guide to Increasing Efficiency, Reducing Variability, and Expanding Applications
         Abstract | Full Text:  HTML   PDF

Unit 11.22 Behavioral Phenotyping for Autism Spectrum Disorders in Mice
         Abstract | Full Text:  HTML   PDF

Unit 14.15 A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture
         Abstract | Full Text:  HTML   PDF

Unit 14.16 Use of Primary Rat Hepatocytes for Prediction of Drug-Induced Mitochondrial Dysfunction
         Abstract | Full Text:  HTML   PDF

Unit 14.17 Micropatterned Co-Cultures of Human Hepatocytes and Stromal Cells for the Assessment of Drug Clearance and Drug-Drug Interactions
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 71, February 2017

Unit 2.25 Flow-Cytometry-Based Method to Detect Escherichia coli and Shigella Spp. Using 16S rRNA-Based Probe
         Abstract | Full Text:  HTML   PDF

Unit 14.14 Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS-Based Detection Methods
         Abstract | Full Text:  HTML   PDF

Unit 17.18 Detecting Protein Sulfenylation in Cells Exposed to a Toxicant
         Abstract | Full Text:  HTML   PDF

Unit 17.19 Detection and Manipulation of the Stress Response Protein Metallothionein
         Abstract | Full Text:  HTML   PDF

Unit 24.5 Preparation of Specific Compartments of the Lungs for Pathologic and Biochemical Analysis of Toxicologic Responses
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 70, November 2016

Unit 2.16 Fluorescence-Based Microplate Assays for In Vitro Assessment of Mitochondrial Toxicity, Metabolic Perturbation, and Cellular Oxygenation
         Abstract | Full Text:  HTML   PDF

Appendix 3B Basic Techniques in Mammalian Cell Tissue Culture
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 69, August 2016

Unit 9.10 A High-Throughput Screening Assay to Identify Kidney Toxic Compounds
         Abstract | Full Text:  HTML   PDF

Unit 20.12 Methods for the Detection of Autophagy in Mammalian Cells
         Abstract | Full Text:  HTML   PDF

Unit 25.8 In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 68, May 2016

Unit 2.24 Determination of Metabolic Viability and Cell Mass Using a Tandem Resazurin/Sulforhodamine B Assay
         Abstract | Full Text:  HTML   PDF

Unit 18.18 Investigating the Effects of Particulate Matter on House Dust Mite and Ovalbumin Allergic Airway Inflammation in Mice
         Abstract | Full Text:  HTML   PDF

Unit 22.4 Multielectrode Array (MEA) Assay for Profiling Electrophysiological Drug Effects in Human Stem Cell-Derived Cardiomyocytes
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 67, February 2016

Unit 11.21 A Simple Light Stimulation of Caenorhabditis elegans
         Abstract | Full Text:  HTML   PDF

Unit 14.13 The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases
         Abstract | Full Text:  HTML   PDF

Unit 18.1 Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment
         Abstract | Full Text:  HTML   PDF

Unit 18.9 Evaluation of Toxicity in Mouse Bone Marrow Progenitor Cells
         Abstract | Full Text:  HTML   PDF

Unit 20.11 PCR-Based Analysis of Mitochondrial DNA Copy Number, Mitochondrial DNA Damage, and Nuclear DNA Damage
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 66, November 2015

Unit 3.13 Use of Ciliogenesis to Detect Aneugens: The Role of Primary Cilia
         Abstract | Full Text:  HTML   PDF

Unit 18.8 Immune Cell Phenotyping Using Flow Cytometry
         Abstract | Full Text:  HTML   PDF

Unit 20.10 Caenorhabditis elegans as a Model for Toxic Effects of Nanoparticles: Lethality, Growth, and Reproduction
         Abstract | Full Text:  HTML   PDF

Unit 25.6 Measuring p66Shc Signaling Pathway Activation and Mitochondrial Translocation in Cultured Cells
         Abstract | Full Text:  HTML   PDF

Unit 25.7 Seahorse Xfe24 Extracellular Flux Analyzer-Based Analysis of Cellular Respiration in Caenorhabditis elegans
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 65, August 2015

Unit 3.12 Alkaline Comet Assay for Assessing DNA Damage in Individual Cells
         Abstract | Full Text:  HTML   PDF

Unit 4.42 Determination of Metabolic Stability Using Cryopreserved Hepatocytes from Rainbow Trout (Oncorhynchus mykiss)
         Abstract | Full Text:  HTML   PDF

Unit 11.20 RNASeq in C. elegans Following Manganese Exposure
         Abstract | Full Text:  HTML   PDF

Unit 23.8 Pre-Plated Cell Lines for ADMETox Applications in the Pharmaceutical Industry
         Abstract | Full Text:  HTML   PDF

Unit 25.5 Measuring Mitochondrial Membrane Potential with a Tetraphenylphosphonium-Selective Electrode
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 64, May 2015

Unit 6.18 Quantification of Glutathione in Caenorhabditis elegans
         Abstract | Full Text:  HTML   PDF

Unit 11.19 High-Resolution Multi-Photon Imaging of Morphological Structures of Caenorhabditis elegans
         Abstract | Full Text:  HTML   PDF

Unit 17.17 Detection of Bulky Endogenous Oxidative DNA Lesions Derived from 8,5′-Cyclo-2′-deoxyadenosine by 32P-Postlabeling Assay
         Abstract | Full Text:  HTML   PDF

Unit 20.9 microRNA Profiling as Tool for Developmental Neurotoxicity Testing (DNT)
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 63, February 2015

Unit 4.41 Metabolism of Xenobiotics by Aldehyde Oxidase
         Abstract | Full Text:  HTML   PDF

Unit 11.18 Methods to Measure Olfactory Behavior in Mice
         Abstract | Full Text:  HTML   PDF

Unit 24.3 How to Measure Alterations in Alveolar Barrier Function as a Marker of Lung Injury
         Abstract | Full Text:  HTML   PDF

Unit 24.4 Inhalation Toxicology Methods: The Generation and Characterization of Exposure Atmospheres and Inhalational Exposures
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 62, November 2014

Unit 11.17 F3-Isoprostanes as a Measure of in vivo Oxidative Damage in Caenorhabditis elegans
         Abstract | Full Text:  HTML   PDF

Unit 14.12 The History and Use of Human Hepatocytes for the Treatment of Liver Diseases: The First 100 Patients
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 61, August 2014

Unit 1.13 Using the Cytosensor Microphysiometer to Assess Ocular Toxicity
         Abstract | Full Text:  HTML   PDF

Unit 23.7 Current Concepts in Drug-Induced Bile Salt Export Pump (BSEP) Interference
         Abstract | Full Text:  HTML   PDF

Unit 24.2 Isolation of Endothelial Cells from Mouse Lung
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 60, May 2014

Unit 12.22 Synaptic Structure Quantification in Cultured Neurons
         Abstract | Full Text:  HTML   PDF

Unit 25.2 Measuring Mitochondrial Function in Permeabilized Cells Using the Seahorse XF Analyzer or a Clark-Type Oxygen Electrode
         Abstract | Full Text:  HTML   PDF

Unit 25.3 Assessment of Fatty Acid Beta Oxidation in Cells and Isolated Mitochondria
         Abstract | Full Text:  HTML   PDF

Unit 25.4 Identifying Compounds that Induce Opening of the Mitochondrial Permeability Transition Pore in Isolated Rat Liver Mitochondria
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 59, February 2014

Unit 1.12 Developmental Toxicity Assays Using the Drosophila Model
         Abstract | Full Text:  HTML   PDF

Unit 12.21 Comparative Human and Rat “Neurosphere Assay” for Developmental Neurotoxicity Testing
         Abstract | Full Text:  HTML   PDF

Unit 25.1 High-Content Imaging Assays for Identifying Compounds that Generate Superoxide and Impair Mitochondrial Membrane Potential in Adherent Eukaryotic Cells
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 58, November 2013

Unit 4.40 Multi-Parametric Analysis of Cell Death Pathways Using Live-Cell Microscopy
         Abstract | Full Text:  HTML   PDF

Unit 17.16 Measurement of Arginine Metabolites: Regulators of Nitric Oxide Metabolism
         Abstract | Full Text:  HTML   PDF

Unit 18.17 In Vitro Assays of Chemotaxis as a Window into Mechanisms of Toxicant-Induced Immunomodulation
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 57, September 2013

Unit 6.17 Methods to Detect Protein Glutathionylation
         Abstract | Full Text:  HTML   PDF

Unit 21.12 In Vivo Measurement of Intragastric Pressure with a Rubber Balloon in the Anesthetized Rat
         Abstract | Full Text:  HTML   PDF

Unit 23.6 Assessment of Drug Transporter Function Using Fluorescent Cell Imaging
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 56, May 2013

Unit 1.5 The Use of Fish-Derived Cell Lines for Investigation of Environmental Contaminants: An Update Following OECD’s Fish Toxicity Testing Framework N◦ 171
         Abstract | Full Text:  HTML   PDF

Unit 1.11 Minipigs: Applications in Toxicology
         Abstract | Full Text:  HTML   PDF

Unit 4.39 Simultaneous, Untargeted Metabolic Profiling of Polar and Nonpolar Metabolites by LC-Q-TOF Mass
         Abstract | Full Text:  HTML   PDF

Unit 12.20 Assessment of Adult Neurogenesis in Mice
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 55, February 2013

Unit 2.23 High-Throughput, Cell-Based Screens to Identify Small-Molecule Inhibitors of Ricin Toxin and Related Category B Ribosome Inactivating Proteins (RIPs)
         Abstract | Full Text:  HTML   PDF

Unit 14.11 High-Throughput Gene Silencing and mRNA Expression Analysis in Hepatocyte Sandwich Cultures
         Abstract | Full Text:  HTML   PDF

Unit 16.10 Preparation of Rodent Testis Co-Cultures
         Abstract | Full Text:  HTML   PDF

Unit 24.1 In Situ Measurement of Vapor Uptake in the Rodent Upper Respiratory Tract
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 54, November 2012

Unit 20.8 The NCTC 2544 IL-18 Assay for the In Vitro Identification of Contact Allergens
         Abstract | Full Text:  HTML   PDF

Unit 21.11 Assessment of Intestinal Peristalsis in Vitro
         Abstract | Full Text:  HTML   PDF

Unit 23.4 The Vesicular Transport Assay: Validated In Vitro Methods to Study Drug-Mediated Inhibition of Canalicular Efflux Transporters ABCB11/BSEP and ABCC2/MRP2
         Abstract | Full Text:  HTML   PDF

Unit 23.5 Membrane Vesicle ABC Transporter Assays for Drug Safety Assessment
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 53, August 2012

Unit 14.9 Assessing Cell Fusion and Cytokinesis Failure as Mechanisms of Clone 9 Hepatocyte Multinucleation In Vitro
         Abstract | Full Text:  HTML   PDF

Unit 14.10 Assessment of Metabolic Stability Using the Rainbow Trout (Oncorhynchus mykiss) Liver S9 Fraction
         Abstract | Full Text:  HTML   PDF

Unit 18.16 Mining the Salivary Proteome with Grating-Coupled Surface Plasmon Resonance Imaging and Surface Plasmon Coupled Emission Microarrays
         Abstract | Full Text:  HTML   PDF

Unit 21.10 Evaluation of Gastric Ulcerogenic and Healing Impairment Effects of Bisphosphonates: Adverse Gastric Reactions of Bisphosphonate
         Abstract | Full Text:  HTML   PDF

Unit 23.3 Renal Transporters in Drug Disposition, Drug-Drug Interactions, and Nephrotoxicity
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 52, May 2012

Unit 11.16 Morphological Assessment of Neurite Outgrowth in Hippocampal Neuron-Astrocyte Co-Cultures
         Abstract | Full Text:  HTML   PDF

Unit 23.1 Measuring Altered Disposition of Xenobiotics in Experimental Models of Liver Disease
         Abstract | Full Text:  HTML   PDF

Unit 23.2 Use of Zinc Finger Nuclease Technology to Knock Out Efflux Transporters in C2BBe1 Cells
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 51, February 2012

Unit 4.38 CYP1B1 Detection
         Abstract | Full Text:  HTML   PDF

Unit 17.15 High-Throughput, Multiplexed Analysis of 3-Nitrotyrosine in Individual Proteins
         Abstract | Full Text:  HTML   PDF

Unit 18.15 Developmental Immunotoxicity (DIT): Assays for Evaluating Effects of Exogenous Agents on Development of the Immune System
         Abstract | Full Text:  HTML   PDF

Unit 20.7 The Local Lymph Node Assay (LLNA)
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 50, November 2011

Unit 2.22 Murine Embryonic Stem Cell Derivation, In Vitro Pluripotency Characterization, and In Vivo Teratoma Formation
         Abstract | Full Text:  HTML   PDF

Unit 12.19 Methods to Assess Neuroinflammation
         Abstract | Full Text:  HTML   PDF

Unit 22.3 Preparation of Epithelial and Mesenchymal Stem Cells from Murine Mammary Gland
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 49, August 2011

Unit 2.20 Assessment of Mitochondrial Toxicity in HepG2 Cells in Cultured in High-Glucose- or Galactose-Containing Media
         Abstract | Full Text:  HTML   PDF

Unit 2.21 Measuring Intracellular hsp70 in Leukocytes by Flow Cytometry
         Abstract | Full Text:  HTML   PDF

Unit 7.9 Overview of Peroxiredoxins in Oxidant Defense and Redox Regulation
         Abstract | Full Text:  HTML   PDF

Unit 7.10 Measurement of Peroxiredoxin Activity
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 48, May 2011

Unit 2.19 Fluorescence Correlation Spectroscopy: Detecting and Interpreting the Mobility of Transmembrane Proteins In Vivo
         Abstract | Full Text:  HTML   PDF

Unit 3.11 High-Throughput Assays for Assessing Mitochondrial Dysfunction Caused by Compounds that Impair mtDNA-Encoded Protein Levels in Eukaryotic Cells
         Abstract | Full Text:  HTML   PDF

Unit 4.37 Aldehyde Reduction by Cytochrome P450
         Abstract | Full Text:  HTML   PDF

Unit 12.18 Cellular fura-2 Manganese Extraction Assay (CFMEA)
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 47, February 2011

Unit 2.18 Role Integrative Signaling Through Gap Junctions in Toxicology
         Abstract | Full Text:  HTML   PDF

Unit 20.6 Caco-2 Cells as a Model for Intestinal Absorption
         Abstract | Full Text:  HTML   PDF

Unit 22.1 Using Chemotherapeutic Drugs to Trigger Hematopoietic Stem Cell Activation and Determine Hematological Toxicity
         Abstract | Full Text:  HTML   PDF

Unit 22.2 Isolation and Applications of Prostate Side Population Cells Based on Dye Cycle Violet Efflux
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 46, November 2010

Unit 12.16 Morphometric Analysis in Neurodegenerative Disorders
         Abstract | Full Text:  HTML   PDF

Unit 21.8 Assessment of Gastrointestinal Motility Using Three Different Assays In Vitro
         Abstract | Full Text:  HTML   PDF

Unit 21.9 Assessment of Gastrointestinal Propulsive Activity Using Three Different Models of Peristalsis In Vivo in the Mouse
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 45, August 2010

Unit 17.13 Transcription Factor Nrf2: Examination of Nuclear Protein Levels by Immunoblotting and Promoter Response Element Binding by Chromatin Immunoprecipitation (ChIP)
         Abstract | Full Text:  HTML   PDF

Unit 17.14 LC-MS/MS Quantitation of Mercapturic Acid Conjugates of Lipid Peroxidation Products as Markers of Oxidative Stress
         Abstract | Full Text:  HTML   PDF

Unit 21.5 Measurement of Gastric Acid Secretion in the Anaesthetized Rat
         Abstract | Full Text:  HTML   PDF

Unit 21.6 Endogenous Gastric Mediators: Patho-Physiological Role and Measurements
         Abstract | Full Text:  HTML   PDF

Unit 21.7 Measurement of Small Intestinal Damage
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 44, May 2010

Unit 4.36 Measurement of Cysteine S-Conjugate β-Lyase Activity
         Abstract | Full Text:  HTML   PDF

Unit 14.8 Assessment of Mitochondrial Dysfunction Arising from Treatment with Hepatotoxicants
         Abstract | Full Text:  HTML   PDF

Unit 21.3 Assessment of Enteral Bacteria
         Abstract | Full Text:  HTML   PDF

Unit 21.4 Assessment of Ischemic Vascular Damage
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 43, February 2010

Unit 4.35 Manipulation of Expression of Arsenic (+3 Oxidation State) Methyltransferase in Cultured Cells
         Abstract | Full Text:  HTML   PDF

Unit 12.16 Morphometric Analysis in Neurodegenerative Disorders
         Abstract | Full Text:  HTML   PDF

Unit 12.17 Neonatal Rat Primary Microglia: Isolation, Culturing, and Selected Applications
         Abstract | Full Text:  HTML   PDF

Unit 21.1 Overview of Gastrointestinal Toxicology
         Abstract | Full Text:  HTML   PDF

Unit 21.2 Methods to Measure Gastric Mucosal Lesions in the Rat
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 42, November 2009

Unit 4.30 Co-Oxidation by Cyclooxygenases
         Abstract | Full Text:  HTML   PDF

Unit 4.31 An Overview of Arsenic Metabolism and Toxicity
         Abstract | Full Text:  HTML   PDF

Unit 4.32 In Vitro Assays of Inorganic Arsenic Methylation
         Abstract | Full Text:  HTML   PDF

Unit 4.33 Analysis of Arsenical Metabolites in Biological Samples
         Abstract | Full Text:  HTML   PDF

Unit 4.34 Purification of Arsenic (+3 Oxidation State) Methyltransferase from Rat Liver Cytosol
         Abstract | Full Text:  HTML   PDF

Unit 12.15 Application of Single-Cell Microfluorimetry to Neurotoxicology Assays
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 41, August 2009

Unit 2.17 Assessment of Gap Junctional Intercellular Communication
         Abstract | Full Text:  HTML   PDF

Unit 4.28 Azoreductase in Staphylococcus aureus
         Abstract | Full Text:  HTML   PDF

Unit 4.29 Measurement of Phenylalanine Monooxygenase (PAH) Activities
         Abstract | Full Text:  HTML   PDF

Unit 5.8 Determination of ADME and Bioavailability Following Intravenous, Oral, and Dermal Routes of Exposure
         Abstract | Full Text:  HTML   PDF

Unit 17.12 Thioredoxin Redox Western Analysis
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 40, May 2009

Unit 2.15 Current Concepts in Drug-Induced Mitochondrial Toxicity
         Abstract | Full Text:  HTML   PDF

Unit 2.16 Fluoroscent pH and Oxygen Probes of the Assessment of Mitochondrial Toxicity in Isolated Mitochondria and Whole Cells
         Abstract | Full Text:  HTML   PDF

Unit 17.11 Measuring Electrophile Stress
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 39, February 2009

Unit 1.10 Use of Medaka in Toxicity Testing
         Abstract | Full Text:  HTML   PDF

Unit 4.27 Measurement of In Vitro Cytochrome P450 2B6 Activity
         Abstract | Full Text:  HTML   PDF

Unit 6.16 Glutamate Cysteine Ligase (GCL) Transgenic and Gene-Targeted Mice for Controlling Glutathione Synthesis
         Abstract | Full Text:  HTML   PDF

Unit 12.14 Measurement of Isoprostanes as Markers of Oxidative Stress in Neuronal Tissue
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 38, November 2008

Unit 4.26 Assays for S-Adenosylmethionine (AdoMet/SAM)-Dependent Methyltransferases
         Abstract | Full Text:  HTML   PDF

Unit 6.15 Measurement of Cysteine Dioxygenase Activity and Protein Abundance
         Abstract | Full Text:  HTML   PDF

Unit 17.2 Measurement of Protein Sulfenic Acid Content
         Abstract | Full Text:  HTML   PDF

Unit 17.10 Complex I Assay in Mitochondrial Preparations from CNS
         Abstract | Full Text:  HTML   PDF

[Top of Page]



 Supplement 37, August 2008

Unit 14.7 A Rat Primary Hepatocyte Culture Model for Aging Studies
         Abstract | Full Text:  HTML   PDF

Unit 20.5 CFU-MK Assay for Acute Thrombocytopenia
         Abstract | Full Text:  HTML   PDF

Appendix 1A Safe Use of Radioisotopes
         Abstract | Full Text:  HTML   PDF

Appendix 1C Radioactivity
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 36, May 2008

Unit 2.14 Cross-Species Genetic Toxicity Assessment Accomplished by Flow Cytometric Analysis of Blood
         Abstract | Full Text:  HTML   PDF

Unit 18.14 Analysis of Modulation of Immunoglobulin Gene Expression
         Abstract | Full Text:  HTML   PDF

Unit 20.4 Neutral Red Uptake Cytotoxicity Tests for Estimating Starting Doses for Acute Oral Toxicity Tests
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 35, February 2008

Unit 6.14 Measurement of Aminoacylases
         Abstract | Full Text:  HTML   PDF

Unit 11.15 Experimental Models of Hypoxic-Ischemic Encephalopathy: Hypoxia-Ischemia in the Immature Rat
         Abstract | Full Text:  HTML   PDF

Unit 17.9 Identification and Characterization of Oxylipid-Protein and Peptide Conjugates by Mass Spectrometry
         Abstract | Full Text:  HTML   PDF

Unit 20.3 The Syrian Hamster Embryo (SHE) Low pH Cell Transformation Assay
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 34, November 2007

Unit 6.12 Glutathione-Dependent Bioactivation
         Abstract | Full Text:  HTML   PDF

Unit 6.13 Methods for Measuring Cysteine S -Conjugate β-Lyase Activity
         Abstract | Full Text:  HTML   PDF

Unit 12.13 Determination of Cholinesterase in Blood and Tissue
         Abstract | Full Text:  HTML   PDF

Unit 20.1 Overview of Alternative Methodologies in Toxicology
         Abstract | Full Text:  HTML   PDF

Unit 20.2 CFU-GM Assay for Evaluation of Drug Myelotoxic Activity
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 33, August 2007

Unit 4.23 Measurement of Soluble Epoxide Hydrolase (sEH) Activity
         Abstract | Full Text:  HTML   PDF

Unit 4.24 Enzymatic Activity of Human Carboxylesterases
         Abstract | Full Text:  HTML   PDF

Unit 4.25 In Vitro Evaluation of Metabolic Drug-Drug Interactions: A Descriptive and Critical Commentary
         Abstract | Full Text:  HTML   PDF

Unit 18.13 Fluorescence Microscopy and Flow Cytometric Analysis of Peyer's Patches and Intestinal Immune Cells
         Abstract | Full Text:  HTML   PDF

Appendix 3B Techniques for Mammalian Cell Tissue Culture
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 32, May 2007

Unit 4.22 Biochemical and Genetic Analysis of NAD(P)H:Quinone Oxidoreductase 1 (NQO1)
         Abstract | Full Text:  HTML   PDF

Unit 14.6 Measuring Covalent Binding in Hepatotoxicity
         Abstract | Full Text:  HTML   PDF

Appendix 3F One-Dimensional SDS Gel Electrophoresis of Proteins
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 31, February 2007

Unit 1.9 The Nematode C. elegans as an Animal Model to Explore Toxicology In Vivo: Solid and Axenic Growth Culture Conditions and Compound Exposure Parameters
         Abstract | Full Text:  HTML   PDF

Unit 2.13 Mouse Models for Human Hemato-Lymphopoiesis
         Abstract | Full Text:  HTML   PDF

Unit 19.1 Toxicology Testing in Drug Discovery and Development
         Abstract | Full Text:  HTML   PDF

Unit 19.2 Toxicity Testing in Chemical Safety Evaluation
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 30, November 2006

Unit 2.12 Detection of the Mitochondrial Apoptosis-Induced Channel (MAC) and Its Regulation by Bcl-2 Family Proteins
         Abstract | Full Text:  HTML   PDF

Unit 4.21 Monoamine Oxidase Assays
         Abstract | Full Text:  HTML   PDF

Unit 13.12 Analysis of Ultrasonic Vocalizations Emitted by Infant Rodents
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 29, August 2006

Unit 4.20 NMR Analysis of Thiodiglycol Oxidation by Mammalian Alcohol Dehydrogenases
         Abstract | Full Text:  HTML   PDF

Unit 7.8 Measurement of the Vitamin E Metabolites, Carboxyethyl Hydroxychromans (CEHCs), in Biological Samples
         Abstract | Full Text:  HTML   PDF

Unit 18.11 Analysis of Immunotoxicity by Enumeration of Antibody-Producing B Cells
         Abstract | Full Text:  HTML   PDF

Unit 18.12 The Reporter Antigen Popliteal Lymph Node Assay
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 28, May 2006

Unit 3.10 Analysis of Mismatch Repair in Human Nuclear Extracts
         Abstract | Full Text:  HTML   PDF

Unit 6.10 Overview of Protein Glutathionylation
         Abstract | Full Text:  HTML   PDF

Unit 6.11 Measurement of Protein Glutathionylation
         Abstract | Full Text:  HTML   PDF

Unit 17.8 Detection of Stress Proteins as Biomarkers of Oxidative Stress
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 27, February 2006

Unit 2.11 Single-Cell Analysis of Lipid Rafts in Lymphocytes and in T Cell–Containing Immunoconjugates
         Abstract | Full Text:  HTML   PDF

Unit 4.19 Measurement of Human Cytochrome P4501A2 ( CYP1A2 ) Activity In Vitro
         Abstract | Full Text:  HTML   PDF

Unit 7.7 Catalase Activity Assays
         Abstract | Full Text:  HTML   PDF

Unit 13.11 Scoring Learning and Memory in Developing Rodents
         Abstract | Full Text:  HTML   PDF

Unit 18.10 Host Resistance Model to an Intracellular Pathogen
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 26, November 2005

Unit 4.18 Aldehyde Dehydrogenases: Measurement of Activities and Protein Levels
         Abstract | Full Text:  HTML   PDF

Unit 13.9 Methods in the Analysis of Maternal Behavior in the Rodent
         Abstract | Full Text:  HTML   PDF

Unit 13.10 Scoring of Social Interactions and Play in Mice During Adolescence
         Abstract | Full Text:  HTML   PDF

Unit 16.9 Hershberger Assay to Investigate the Effects of Endocrine-Disrupting Compounds with Androgenic or Antiandrogenic Activity in Castrate-Immature Male Rats
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 25, August 2005

Unit 4.17 Measurement of Xenobiotic Carbonyl Reduction in Human Liver Fractions
         Abstract | Full Text:  HTML   PDF

Unit 13.7 Overview of Behavioral Teratology
         Abstract | Full Text:  HTML   PDF

Unit 13.8 Statistical Analysis of Behavioral Data
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 24, May 2005

Unit 4.16 Evaluation of the Cytochrome b 5 /Cytochrome b 5 Reductase Pathway
         Abstract | Full Text:  HTML   PDF

Unit 17.5 F 2 -Isoprostanes as Markers of Oxidant Stress: An Overview
         Abstract | Full Text:  HTML   PDF

Unit 17.6 Quantification of F 2 -Isoprostanes by Gas Chromatography/Mass Spectrometry as a Measure of Oxidant Stress
         Abstract | Full Text:  HTML   PDF

Unit 17.7 Immuno-Spin Trapping: Detection of Protein-Centered Radicals
         Abstract | Full Text:  HTML   PDF

Unit 18.9 In Vitro Model for Modulation of Helper T Cell Differentiation and Activation
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 23, February 2005

Unit 11.14 Methods to Produce Brain Hyperthermia
         Abstract | Full Text:  HTML   PDF

Unit 18.7 Solid-Phase Immunoassays
         Abstract | Full Text:  HTML   PDF

Unit 18.8 Immune Cell Phenotyping Using Flow Cytometry
         Abstract | Full Text:  HTML   PDF

Appendix 3I The Colorimetric Detection and Quantitation of Total Protein
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 22, November 2004

Unit 4.15 TaqMan Real Time–Polymerase Chain Reaction Methods for Determination of Nucleotide Polymorphisms in Human N -Acetyltransferase-1 ( NAT1 ) and -2 ( NAT2 )
         Abstract | Full Text:  HTML   PDF

Unit 5.7 Collection of Bile and Urine Samples for Determining the Urinary and Hepatobiliary Disposition of Xenobiotics in Mice
         Abstract | Full Text:  HTML   PDF

Unit 11.13 Detection and Assessment of Xenobiotic-Induced Sensory Neuropathy
         Abstract | Full Text:  HTML   PDF

Unit 12.12 Morphological Measurement of Neurotoxic Injury in the Peripheral Nervous System: Preparation of Material for Light and Transmission Electron Microscopic Evaluation
         Abstract | Full Text:  HTML   PDF

Unit 18.5 Measuring Lymphocyte Transcription Factor Activity by ELISA
         Abstract | Full Text:  HTML   PDF

Unit 18.6 Measuring the Activity of Cytolytic Lymphocytes
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 21, August 2004

Unit 4.14 Biotransformation Studies Using Rat Proximal Tubule Cells
         Abstract | Full Text:  HTML   PDF

Unit 18.3 Murine Asthma Models
         Abstract | Full Text:  HTML   PDF

Unit 18.4 Use of Bronchoalveolar Lavage to Detect Lung Injury
         Abstract | Full Text:  HTML   PDF

Appendix 3G Spectrophotometric Determination of Protein Concentration
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 20, May 2004

Unit 4.13 Human Cytochrome P450: Metabolism of Testosterone by CYP3A4 and Inhibition by Ketoconazole
         Abstract | Full Text:  HTML   PDF

Unit 17.4 In Situ Localization of Nonenzymatic Peroxidase-Like Activity of Tissue-Bound Transition Metals
         Abstract | Full Text:  HTML   PDF

Unit 18.1 Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment
         Abstract | Full Text:  HTML   PDF

Unit 18.2 Local Lymph Node Assays
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 19, February 2004

Unit 2.10 Analysis of Mitochondrial Dysfunction During Cell Death
         Abstract | Full Text:  HTML   PDF

Unit 4.12 Determination of Paraoxonase 1 Status and Genotypes at Specific Polymorphic Sites
         Abstract | Full Text:  HTML   PDF

Unit 14.5 Measurement of Hepatobiliary Transport
         Abstract | Full Text:  HTML   PDF

Unit 16.8 Transgenerational (In Utero/Lactational) Exposure to Investigate the Effects of Endocrine Disrupting Compounds (EDCs) in Rats
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 18, November 2003

Unit 1.8 Preclinical Models of Parkinson's Disease
         Abstract | Full Text:  HTML   PDF

Unit 12.11 Determining the Ability of Xenobiotic Metals to Bind a Specific Protein Domain by Electrophoresis
         Abstract | Full Text:  HTML   PDF

Unit 17.1 Formation and Functions of Protein Sulfenic Acids
         Abstract | Full Text:  HTML   PDF

Unit 17.2 Measurement of Protein Sulfenic Acid Content
         Full Text:  HTML   PDF

Unit 17.3 Fluorescence Microplate Reader Measurement of Tissue Susceptibility to Lipid Peroxidation
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 17, August 2003

Unit 1.7 Zebrafish: An Animal Model for Toxicological Studies
         Abstract | Full Text:  HTML   PDF

Unit 11.10 Principles of Electrophysiology: An Overview
         Abstract | Full Text:  HTML   PDF

Unit 11.11 Electrophysiological Studies of Neurotoxicants on Central Synaptic Transmission in Acutely Isolated Brain Slices
         Abstract | Full Text:  HTML   PDF

Unit 11.12 Whole-Cell Patch-Clamp Electrophysiology of Voltage-Sensitive Channels
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 16, May 2003

Unit 1.6 Sea Urchin Embryos and Larvae as Biosensors for Neurotoxicants
         Abstract | Full Text:  HTML   PDF

Unit 13.5 In Vivo Assessment of Prenatal Developmental Toxicity in Rodents
         Abstract | Full Text:  HTML   PDF

Unit 13.6 Organ Culture of Midfacial Tissue and Secondary Palate
         Abstract | Full Text:  HTML   PDF

Unit 16.7 Performing a Testicular Spermatid Head Count
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 15, February 2003

Unit 1.5 The Use of Fish-Derived Cell Lines for Investigation of Environmental Contaminants
         Abstract | Full Text:  HTML   PDF

Unit 5.6 Toxicant Transport by P-Glycoprotein
         Abstract | Full Text:  HTML   PDF

Unit 6.9 Coenzyme A and Coenzyme A-Glutathione Mixed Disulfide Measurements by HPLC
         Abstract | Full Text:  HTML   PDF

Unit 9.9 Purification and Characterization of Heme Oxygenase
         Abstract | Full Text:  HTML   PDF

Unit 12.9 Aggregating Neural Cell Cultures
         Abstract | Full Text:  HTML   PDF

Unit 12.10 Coculturing Neurons and Glial Cells
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 14, November 2002

Unit 4.11 Techniques for Measuring the Activity of Carboxylic Acid:CoA Ligase and Acyl-CoA:Amino Acid N -Acyltransferase: The Amino Acid Conjugation Pathway
         Abstract | Full Text:  HTML   PDF

Unit 6.8 Measurement of Glutathione Conjugates
         Abstract | Full Text:  HTML   PDF

Unit 13.4 Using Chicken Embryos for Teratology Studies
         Abstract | Full Text:  HTML   PDF

Unit 14.4 Isolation of Liver Kupffer Cells
         Abstract | Full Text:  HTML   PDF

Unit 16.6 Epididymal Sperm Count
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 13, August 2002

Unit 4.9 Measurements of Flavin-Containing Monooxygenase (FMO) Activities
         Abstract | Full Text:  HTML   PDF

Unit 4.10 Assays for the Classification of Two Types of Esterases: Carboxylic Ester Hydrolases and Phosphoric Triester Hydrolases
         Abstract | Full Text:  HTML   PDF

Unit 16.4 Histopathology of the Male Reproductive System II: Interpretation
         Abstract | Full Text:  HTML   PDF

Unit 16.5 Monitoring Endocrine Function in Males: Using Intra-Atrial Cannulas to Monitor Plasma Hormonal Dynamics in Toxicology Experiments
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 12, May 2002

Unit 3.8 Methods for Measuring DNA Adducts and Abasic Sites I: Isolation, Purification, and Analysis of DNA Adducts in Intact DNA
         Abstract | Full Text:  HTML   PDF

Unit 3.9 Methods for Measuring DNA Adducts and Abasic Sites II: Methods for Measurement of DNA Adducts
         Abstract | Full Text:  HTML   PDF

Unit 7.6 Measurement of Ascorbic Acid and Dehydroascorbic Acid in Biological Samples
         Abstract | Full Text:  HTML   PDF

Unit 9.8 Quantitation of Human Heme Oxygenase (HO-1) Copies by Competitive RT-PCR
         Abstract | Full Text:  HTML   PDF

Unit 16.3 Histopathology of the Male Reproductive System I: Techniques
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 11, February 2002

Unit 4.8 Analysis of the Aryl Hydrocarbon Receptor (AhR) Signal Transduction Pathway
         Abstract | Full Text:  HTML   PDF

Unit 12.8 Measurement of Glial Fibrillary Acidic Protein
         Abstract | Full Text:  HTML   PDF

Unit 14.3 Small Animal Models of Hemorrhagic Shock–Induced Liver Dysfunction
         Abstract | Full Text:  HTML   PDF

Unit 16.1 In Vivo Models for Male Reproductive Toxicology
         Abstract | Full Text:  HTML   PDF

Unit 16.2 Guidelines for Mating Rodents
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 10, November 2001

Unit 4.6 Measuring the Activity of Arylamine N -Acetyltransferase (NAT)
         Abstract | Full Text:  HTML   PDF

Unit 4.7 Measurement of Carboxylesterase (CES) Activities
         Abstract | Full Text:  HTML   PDF

Unit 15.3 Aggregation Chimeras (ES Cell–Embryo)
         Abstract | Full Text:  HTML   PDF

Unit 15.4 Reporter Genes to Detect Cre Excision in Mice
         Abstract | Full Text:  HTML   PDF

Appendix 3G Spectrophotometric and Colorimetric Determination of Protein Concentration
        Full Text:  HTML   PDF

Appendix 3H Dialysis and Concentration of Protein Solutions
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 9, August 2001

Unit 1.4 DNA Microarrays: An Overview of Technologies and Applications to Toxicology
         Abstract | Full Text:  HTML   PDF

Unit 5.5 Porcine Skin Flow-Through Diffusion Cell System
         Abstract | Full Text:  HTML   PDF

Unit 12.7 Isolation of Cerebellar Granule Cells from Neonatal Rats
         Abstract | Full Text:  HTML   PDF

Unit 15.1 Embryonic Stem (ES) Cell Culture Basics
         Abstract | Full Text:  HTML   PDF

Unit 15.2 Genotyping Embryonic Stem (ES) Cells
         Abstract | Full Text:  HTML   PDF

Appendix 3F One-Dimensional SDS Gel Electrophoresis of Proteins
        Full Text:  HTML   PDF

[Top of Page]



  Supplement 8, May 2001

Unit 4.5 Measurement of Aryl and Alcohol Sulfotransferase Activity
         Abstract | Full Text:  HTML   PDF

Unit 5.4 Isolated Perfused Porcine Skin Flap
         Abstract | Full Text:  HTML   PDF

Unit 6.7 Oxidant-Induced Regulation of Glutathione Synthesis
         Abstract | Full Text:  HTML   PDF

Unit 7.5 Measurement of MnSOD and CuZnSOD Activity in Mammalian Tissue Homogenates
         Abstract | Full Text:  HTML   PDF

Unit 14.1 Overview of Hepatotoxicity
         Abstract | Full Text:  HTML   PDF

Unit 14.2 Preparation of Hepatocytes
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 7, February 2001

Unit 2.9 Measurement of Expression of the HSP70 Protein Family
         Abstract | Full Text:  HTML   PDF

Unit 8.9 HPLC Methods for Analysis of Porphyrins in Biological Media
         Abstract | Full Text:  HTML   PDF

Unit 13.3 Micromass Cultures in Teratology
         Abstract | Full Text:  HTML   PDF

Appendix 3D Detection and Quantitation of Radiolabeled Proteins in Gels and Blots
         Abstract | Full Text:  HTML   PDF

Appendix 3E Northern Blot Analysis of RNA
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 6, November 2000

Unit 9.7 Functional Analysis of the Heme Oxygenase-1 Gene Promoter
         Abstract | Full Text:  HTML   PDF

Unit 11.9 Mouse Models of Focal Cerebral Ischemia
         Abstract | Full Text:  HTML   PDF

Unit 12.6 Estimating Cell Number in the Central Nervous System by Stereological Methods: The Optical Disector and Fractionator
         Abstract | Full Text:  HTML   PDF

Unit 13.1 Overview of Teratology
         Abstract | Full Text:  HTML   PDF

Unit 13.2 Rat Embryo Cultures for In Vitro Teratology
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 5, August 2000

Unit 2.7 In Situ Hybridization Histochemistry
         Abstract | Full Text:  HTML   PDF

Unit 2.8 Confocal Microscopy
         Abstract | Full Text:  HTML   PDF

Unit 6.6 γ-Glutamyl Transpeptidase Activity Assay
         Abstract | Full Text:  HTML   PDF

Unit 7.4 Measurement of Thioredoxin and Thioredoxin Reductase
         Abstract | Full Text:  HTML   PDF

Unit 9.6 An HPLC Method to Detect Heme Oxygenase Activity
         Abstract | Full Text:  HTML   PDF

Unit 11.8 Mouse Models of Global Cerebral Ischemia
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 4, May 2000

Unit 5.3 Measurement of Disposition Half-Life, Clearance, and Residence Times
         Abstract | Full Text:  HTML   PDF

Unit 10.9 Inducible Nitric Oxide Synthase Expression
         Abstract | Full Text:  HTML   PDF

Unit 12.3 Culturing Rat Hippocampal Neurons
         Abstract | Full Text:  HTML   PDF

Unit 12.4 Isolation of Neonatal Rat Cortical Astrocytes for Primary Cultures
         Abstract | Full Text:  HTML   PDF

Unit 12.5 Analytical Cytology: Applications to Neurotoxicology
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 3, February 2000

Unit 2.6 In Vitro Methods for Detecting Cytotoxicity
         Abstract | Full Text:  HTML   PDF

Unit 3.6 Detecting Epigenetic Changes: DNA Methylation
         Abstract | Full Text:  HTML   PDF

Unit 3.7 Assays for Detecting Chromosomal Aberrations
         Abstract | Full Text:  HTML   PDF

Unit 4.4 Detection of Metabolites Using High-Performance Liquid Chromatography and Mass Spectrometry
         Abstract | Full Text:  HTML   PDF

Unit 10.8 Methods for Distinguishing Nitrosative and Oxidative Chemistry of Reactive Nitrogen Oxide Species Derived from Nitric Oxide
         Abstract | Full Text:  HTML   PDF

Unit 12.1 Biochemical Approaches to Studying Neurotoxicity
         Abstract | Full Text:  HTML   PDF

Unit 12.2 Development of an In Vitro Blood-Brain Barrier
         Abstract | Full Text:  HTML   PDF

Appendix 3C Enzymatic Amplification of DNA by PCR: Standard Procedures and Optimization
         Abstract | Full Text:  HTML   PDF

[Top of Page]



  Supplement 2, November 1999

Unit 3.5 Assays for DNA Damage
         Abstract | Full Text:  HTML   PDF

Unit 8.7 Measurement of Ferrochelatase Activity
         Abstract | Full Text:  HTML   PDF

Unit 8.8 Measurement of Erythrocyte Protoporphyrin Concentration by Double Extraction and Spectrofluorometry
         Abstract | Full Text:  HTML   PDF

Unit 10.7 Immunocytochemical Analysis of Cyclic Nucleotides
         Abstract | Full Text:  HTML   PDF

Unit 11.6 Risk Assessment and Neurotoxicology
         Abstract | Full Text:  HTML   PDF

Unit 11.7 Neurobehavioral Testing in Humans
         Abstract | Full Text:  HTML   PDF

Appendix 3B Techniques for Mammalian Cell Tissue Culture
        Full Text:  HTML   PDF

[Top of Page]



  Supplement 1, August 1999

Unit 2.5 Measurements of Intracellular Free Calcium Concentration in Biological Systems
         Abstract | Full Text:  HTML   PDF

Unit 3.3 Mutagenesis Assays in Mammalian Cells
         Abstract | Full Text:  HTML   PDF

Unit 3.4 Cell Transformation Assays
         Abstract | Full Text:  HTML   PDF

Unit 8.6 Measurement of δ-Aminolevulinate Dehydratase Activity
         Abstract | Full Text:  HTML   PDF

Unit 9.5 Histochemical Analysis of Heme Degradation Enzymes
         Abstract | Full Text:  HTML   PDF

Unit 10.6 Histochemical Analysis of Nitric Oxide Synthase by NADPH Diaphorase Staining
         Abstract | Full Text:  HTML   PDF

Appendix 1B Transgenic and Gene-Targeted Mouse Lines for Toxicology Studies
         Full Text:  HTML   PDF

[Top of Page]



  Core Publication, May 1999

Unit 1.1 Nonhuman Primates as Animal Models for Toxicology Research
         Abstract | Full Text:  HTML   PDF

Unit 1.2 Statistical Approaches to the Design of Toxicology Studies
         Abstract | Full Text:  HTML   PDF

Unit 1.3 Transgenic Animals in Toxicology
         Abstract | Full Text:  HTML   PDF

Unit 2.1 Current Concepts in Cell Toxicity
         Abstract | Full Text:  HTML   PDF

Unit 2.2 Determination of Apoptosis and Necrosis
         Abstract | Full Text:  HTML   PDF

Unit 2.3 Detection of Covalent Binding
         Abstract | Full Text:  HTML   PDF

Unit 2.4 Measurement of Lipid Peroxidation
         Abstract | Full Text:  HTML   PDF

Unit 3.1 The Salmonella (Ames) Test for Mutagenicity
         Abstract | Full Text:  HTML   PDF

Unit 3.2 Measurement of a Malondialdehyde-DNA Adduct
         Abstract | Full Text:  HTML   PDF

Unit 4.1 Measurement of Cytochrome P-450
         Abstract | Full Text:  HTML   PDF

Unit 4.2 Purification of Cytochrome P-450 Enzymes
         Abstract | Full Text:  HTML   PDF

Unit 4.3 Measurements of UDP- Glucuronosyltransferase (UGT) Activities
         Abstract | Full Text:  HTML   PDF

Unit 5.1 Measurement of Bioavailability: Measurement of Absorption Through Skin In Vitro
         Abstract | Full Text:  HTML   PDF

Unit 5.2 Measurement of Bioavailability: Measuring Absorption Through Skin In Vivo in Rats and Humans
         Abstract | Full Text:  HTML   PDF

Unit 6.1 Overview of Glutathione Function and Metabolism
         Abstract | Full Text:  HTML   PDF

Unit 6.2 Measurement of Glutathione and Glutathione Disulfide
         Abstract | Full Text:  HTML   PDF

Unit 6.3 Measurement of Glutathione Transport
         Abstract | Full Text:  HTML   PDF

Unit 6.4 Measurement of Glutathione Transferases
         Abstract | Full Text:  HTML   PDF

Unit 6.5 HPLC-Based Assays for Enzymes of Glutathione Biosynthesis
         Abstract | Full Text:  HTML   PDF

Unit 7.1 Analysis of Glutathione-Related Enzymes
         Abstract | Full Text:  HTML   PDF

Unit 7.2 Measurement of Glutathione Reductase Activity
         Abstract | Full Text:  HTML   PDF

Unit 7.3 Analysis of Superoxide Dismutase Activity
         Abstract | Full Text:  HTML   PDF

Unit 8.1 The Heme Biosynthesis Pathway and Clinical Manifestations of Abnormal Function
         Abstract | Full Text:  HTML   PDF

Unit 8.2 Measurement of ALA Synthase Activity
         Abstract | Full Text:  HTML   PDF

Unit 8.3 Measurement of Heme Concentration
         Abstract | Full Text:  HTML   PDF

Unit 8.4 Measurement of Uroporphyrinogen Decarboxylase Activity
         Abstract | Full Text:  HTML   PDF

Unit 8.5 Measurement of Protoporphyrinogen Oxidase Activity
         Abstract | Full Text:  HTML   PDF

Unit 9.1 Overview of Heme Degradation Pathway
         Abstract | Full Text:  HTML   PDF

Unit 9.2 Detection of Heme Oxygenase Activity by Measurement of CO
         Abstract | Full Text:  HTML   PDF

Unit 9.3 Detection of Heme Oxygenase 1 and 2 Proteins and Bilirubin Formation
         Abstract | Full Text:  HTML   PDF

Unit 9.4 Detection of Biliverdin Reductase Activity
         Abstract | Full Text:  HTML   PDF

Unit 10.1 Overview of the Pathway and Functions of Nitric Oxide
         Abstract | Full Text:  HTML   PDF

Unit 10.2 Assay of Tissue Activity of Nitric Oxide Synthase
         Abstract | Full Text:  HTML   PDF

Unit 10.3 Detection of Nitrosated Proteins
         Abstract | Full Text:  HTML   PDF

Unit 10.4 Fluorometric Techniques for the Detection of Nitric Oxide and Metabolites
         Abstract | Full Text:  HTML   PDF

Unit 10.5 Measurement of cGMP and Soluble Guanylyl Cyclase Activity
         Abstract | Full Text:  HTML   PDF

Unit 11.1 Overview of Neurotoxicology
         Abstract | Full Text:  HTML   PDF

Unit 11.2 Neurobehavioral Screening in Rodents
         Abstract | Full Text:  HTML   PDF

Unit 11.3 Assessment of Spatial Memory
         Abstract | Full Text:  HTML   PDF

Unit 11.4 Advanced Behavioral Testing in Rodents: Assessment of Cognitive Function in Animals
         Abstract | Full Text:  HTML   PDF

Unit 11.5 Testing for Organophosphate-Induced Delayed Polyneuropathy
         Abstract | Full Text:  HTML   PDF

Appendix 1A Safe Use of Radioisotopes
         Abstract | Full Text:  HTML   PDF

Appendix 2A Common Stock Solutions and Buffers
         Abstract | Full Text:  HTML   PDF

Appendix 2B Standard Laboratory Equipment
         Abstract | Full Text:  HTML   PDF

Appendix 3A Molecular Biology Techniques
         Abstract | Full Text:  HTML   PDF

SEARCH