Current Protocols in Toxicology

Current Protocols in Toxicology

Online ISBN: 9780471140856

DOI: 10.1002/0471140856

Mission Statement

Sound and reproducible laboratory methods are the foundation of scientific discovery. Yet, all too often, nuances that are critical for an experiment’s success are not captured in the primary literature but exist only as part of a lab’s oral tradition. The aim of each Current Protocols title is to provide the clearest, most detailed and reliable step-by-step instructions for all protocols relevant to a given subject area. Written by experts in the field and extensively edited to our exacting standards, each article also provides invaluable discussions of background information, applications of the methods, important assumptions, key parameters, troubleshooting tips, time considerations, and more. Furthermore, Current Protocols content is thoughtfully organized by topic for optimal usage and to maximize contextual knowledge. Quarterly installments allow Current Protocols to constantly evolve to keep pace with the newest discoveries and developments.

Current Protocols in Toxicology takes a multidisciplinary approach to providing toxicologists, pharmacologists, risk analyzers, environmentalists and others with the research tools they need to analyze the effects of environmental agents, toxicants, and xenobiotics on animals and humans. The carefully edited step-by-step protocols and related commentary are written by scientists in the field from around the world. Updated quarterly with new and revised material, Current Protocols in Toxicology includes classic and up-to-date methods for study of cell toxicity and cell death, DNA changes with exposure, biotransformation mechanisms, pharmacokinetics, bioavailablity, behavioral and biochemical neurotoxicology, teratology and developmental toxicology, reproductive toxicology, hepatotoxicology, oxidative stress, and immunotoxicology. Methods for characterizing the functions of specific molecular pathways—e.g., glutathione, antioxidant enzymes, heme, nitric oxide—and specific organ systems—e.g., liver, renal, and reproductive system—are included. Model systems include nonhuman primates, zebrafish, sea urchins, and rodents.

The target audience for Current Protocols in Toxicology is anyone who is conducting research in the broad field of toxicology, with only a minimum of basic laboratory experience. Sufficient detail is provided to permit duplication of the protocols in any laboratory, whatever the disciplinary background or level of sophistication.


toxicologists • pharmacologists • environmental biologists • neurobiologists • biochemists • immunologists • cell biologists • environmental analysts • geneticists • molecular biologists • behaviorists • neurologists • developmental biologists • risk assessors


toxicology, apoptosis, cell toxicity, reproductive biology, neurobiology, teratology, heme, nitric oxide, chemical biotransformation, pharmacokinetics, bioavailability, model organisms, xenobiotic, biotransformation, adduct formation, oxidative stress, biochemistry, toxicokinetics, glutathione, antioxidant, model organisms, laboratory protocols, Current Protocols