Current Protocols in Pharmacology

Current Protocols in Pharmacology

Online ISBN: 9780471141754

DOI: 10.1002/0471141755

About this Book

Online Subscriptions are now available! Visit the How to Order page for more information.

What's New in Current Protocols in Pharmacology
Supplement 70, September 2015

Unit 2.14 Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors
         Abstract | Full Text:  HTML   PDF

Unit 5.4 Models of Inflammation: Carrageenan- or Complete Freund's Adjuvant (CFA)–Induced Edema and Hypersensitivity in the Rat
         Abstract | Full Text:  HTML   PDF

Unit 5.47 Streptozotocin-Induced Diabetic Models in Mice and Rats
         Abstract | Full Text:  HTML   PDF

Unit 14.35 Overview of KRAS-Driven Genetically Engineered Mouse Models of Non-Small Cell Lung Cancer
         Abstract | Full Text:  HTML   PDF

Unit 14.36 Overview of Genetically Engineered Mouse Models of Breast Cancer Used in Translational Biology and Drug Development
         Abstract | Full Text:  HTML   PDF

Developed by pharmacologists and medicinal chemists from academia and industry, Current Protocols in Pharmacology is a key reference work that documents the broad spectrum of integrative techniques used in drug discovery and in the study of disease pathophysiology. The individual units present basic pharmacological techniques, from an assessment of the efficacy of new compounds to the safety pharmacology studies necessary for the regulatory filing of an Investigational New Drug (IND) application. Accompanying expert overviews provide perspective and context, making it easy for newcomers and professionals alike to profitably use Current Protocols in Pharmacology to its fullest extent.

A subscription gives you access to all the content in the collection plus four quarterly issues of new and updated content. Current Protocols in Pharmacology...

  • covers the full range of molecular, cellular, and in vivo pharmacological techniques used in the discovery and study of drugs and NCEs in the anti-infective, cardiovascular, inflammatory (including respiratory and arthritis), neurological, oncological, pain, and psychiatric therapeutic areas
  • presents state-of-the-art techniques for characterizing the interaction of known drugs and NCEs with receptors and enzymes at the molecular and functional levels, together with proven preclinical models of the human disease state to assess efficacy, selectivity, and side effect liabilities
  • provides timely and authoritative overviews on receptor theory and the drug discovery process, from target identification and compound screening to the preclinical IND process

Edited by: S.J. Enna, Editor-in-Chief (University of Kansas Medical Center); Michael Williams, Editor-in-Chief (Northwestern University Feinberg School of Medicine); Terry Kenakin (University of North Carolina School of Medicine); Paul McGonigle (Drexel University College of Medicine); Bruce Ruggeri (Incyte Corporation); Alan D. Wickenden (Janssen Research & Development, LLC); Guest Editor: Xi-Ping Huang (University of North Carolina); Past Editors: John F. Barrett, James Ellis, John W. Ferkany, Roger Frechette, Paul Moser, Roger D. Porsolt, and James P. Sullivan; Past Guest Editor: Brendan J. Canning

Developmental Editor: Gwen P. Taylor

While the authors, editors, and publisher believe that the specification and usage of reagents, equipment, and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they accept no legal responsibility for any errors or omissions, and make no warranty, express or implied, with respect to material contained herein. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. This is particularly important in regard to new or infrequently employed chemicals or experimental reagents. Moreover, the information presented herein is not a substitute for professional judgment, especially as concerns any applications in a clinical setting or the interpretation of results thereby obtained.