Solid-Phase Organic Syntheses, Volume 1

Solid-Phase Organic Syntheses, Volume 1

Editor(s): Anthony W. Czarnik

Published Online: 26 DEC 2001

Print ISBN: 9780471314844

Online ISBN: 9780471220435

DOI: 10.1002/0471220434

About this Book

The rapid expansion of combinatorial chemistry has renewed interest in solid-phase organic synthesis, a method that lends itself well to creating and screening large numbers of lead compounds. Solid-Phase Organic Syntheses, Volume 1 is the first volume in a series that will be updated annually, filling a gap in the existing chemical literature. Providing information previously unavailable from a single resource, this series is dedicated to providing researchers in the field with validated and tested methods for the solid-phase synthesis of interesting and biologically relevant molecules.
Solid-phase methods will virtually always be invented for application in combinatorial organic synthesis. To meet these specific needs, Solid-Phase Organic Syntheses, Volume 1 focuses on a single type of synthetic transformation accomplished on solid support, and indicates how procedures are optimized to work with a structurally-wide variety of reagents. Written by recognized leaders in the field who review and test all chemical protocols before publication, organic transformations are organized by type of compound synthesized and reaction type.
For the first time, experimental details for proven solid-phase synthetic molecules are collected in a single, invaluable resource. Solid-Phase Organic Syntheses, Volume 1 provides combinatorial chemists and researchers in organic chemistry and medicinal chemistry with the tools and descriptive protocols to achieve syntheses of desired compounds using a variety of solid supports and reagents.

Table of contents

    1. You have free access to this content
    2. Chapter 1

      2-Aminothiazoles (pages 1–8)

      Patrick C. Kearney, Monica Fernandez, Mengmeng Fu and John A. Flygare

    3. Chapter 3

      Solid-Phase Synthesis of Ureas on Microtubes (pages 15–40)

      Hui Zhuang, En-Che Yang, Xiao-Yi Xiao and A. W. Czarnik

    4. Chapter 10

      Preparation of Ameba Resin (pages 105–112)

      Paul C. Fritch, Adam M. Fivush and Timothy M. Willson

    5. Chapter 12

      Backbone Amide Linker (BAL) Strategy for Solid-Phase Synthesis (pages 121–138)

      Jordi Alsina, Knud J. Jensen, Michael F. Songster, Josef Vágner, Fernando Albericio and George Barany