Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries
Copyright © 2001 by John Wiley & Sons, Inc.
Editor(s): Peter H. Seeberger
Published Online: 18 FEB 2002
Print ISBN: 9780471378280
Online ISBN: 9780471220442
About this Book
About The Product
Solid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.
With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as:
- Specific oligosaccharide structures used in signal transduction processes
- Preparation and screening of glycopeptide libraries
- Solid-phase carbohydrate synthesis