Vector Targeting for Therapeutic Gene Delivery

Vector Targeting for Therapeutic Gene Delivery

Editor(s): David T. Curiel, Joanne T. Douglas

Published Online: 31 MAR 2003

Print ISBN: 9780471434795

Online ISBN: 9780471234302

DOI: 10.1002/0471234303

About this Book

"...very informative and comprehensive...belongs on the shelf of every library and lab providing essential resources for research on vector design or delivery."

-Cancer Biology and Therapy

This comprehensive volume presents the most recent advances in target definition technology and provides a detailed overview on the rational design of targeted vectors for gene therapy. A theoretical framework for advanced vector design is provided that integrates all of the allied sciences relevant to the study of vector targeting. The text discusses the basic underlying science and then leads to discussions of the various viral vectors and methods of defining targets. Finally, an expert outlook on promising therapeutic applications is offered.

Table of contents

    1. You have free access to this content
    1. You have free access to this content
  1. Part I: Transductionally Targeted Vectors—Nonviral

    1. Chapter 2

      Targeted Gene Delivery via Lipidic Vectors (pages 17–32)

      Song Li, Zheng Ma, Yadi Tan, Feng Liu, John Dileo and Leaf Huang

  2. Part II: Transductionally Targeted Vectors—Viral

    1. Chapter 5

      Pseudotyping of Adenoviral Vectors (pages 87–121)

      Menzo J. E. Havenga, Ronald Vogels, Abraham Bout and Majid Mehtali

    2. Chapter 9

      Conjugate-Based Targeting of Adeno-Associated Virus Vectors (pages 201–219)

      Selvarangan Ponnazhagan, Giandham Mahendra, Aleksandr Pereboev, David T. Curiel and Jürgen Kleinschmidt

    3. Chapter 14

      Genetic Engineering of Targeted Retroviral Vectors (pages 293–320)

      Erlinda M. Gordon, Frederick L. Hall, Robert W. Beart and W. French Anderson

    4. Chapter 15

      Targeting Measles Virus Entry (pages 321–336)

      Anthea L. Hammond, Richard K. Plemper and Roberto Cattaneo

    5. Chapter 16

      Targeting of Poliovirus Replicons to Neurons in the Central Nervous System (pages 337–352)

      Casey D. Morrow, Mathew Palmer, Cheryl A. Jackson, Lisa K. Johansen, Andrea Bledsoe, David D. Ansardi, Donna C. Porter, Charles N. Cobbs and Jean D. Peduzzi

    6. Chapter 18

      Redirecting the Tropism of HSV-1 for Gene Therapy Applications (pages 377–403)

      Qing Bai, Edward A. Burton, William F. Goins and Joseph C. Glorioso

  3. Part III: Transcriptional Targeting

    1. Chapter 24

      Clostridium-Mediated Transfer of Therapeutic Proteins to Solid Tumors (pages 527–546)

      Philippe Lambin, Jan Theys, Sandra Nuyts, Willy Landuyt, Lieve Van Mellaert and Jozef Anné

  4. Part IV: Target Definition

    1. Chapter 25

      Selection of Peptides on Phage (pages 547–579)

      Michael A. Barry, Satoshi Takahashi and M. Brandon Parrott

  5. Part V: Monitoring of Targeting

    1. Chapter 30

      Monitoring Gene Therapy by Positron Emission Tomography (pages 659–685)

      Harvey R. Herschman, Jorge R. Barrio, Nagichettiar Satyamurthy, Qianwa Liang, Duncan C. Maclaren, Shariar Yaghoubi, Tatsushi Toyokuni, Simon R. Cherry, Michael E. Phelps and Sanjiv S. Gambhir

    1. You have free access to this content

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