Burger's Medicinal Chemistry and Drug Discovery
Copyright © 1999-2014 by John Wiley and Sons, Inc. All Rights Reserved.
Online ISBN: 9780471266945
Editors & Contributors
About the Editor
Dr. Abraham is Professor and Chairman of the Department of Medicinal Chemistry, School of Pharmacy and Director of the Institute for Structural Biology and Drug Discovery at Virginia Commonwealth University. Dr. Abraham's research is interdisciplinary and focuses on structure based drug design including X-ray crystallography, molecular modeling, synthetic medicinal chemistry, and structure function studies involving allosteric proteins. Targeted therapeutic areas of research include: Sickle Cell Anemia, radiation oncology, ischemic cardiovascular diseases, stroke, cancer and Alzheimer's disease. Primary areas of drug discovery revolve around allosteric proteins (hemoglobin, P53 and other non-heme proteins) that may be regulated by synthetic allosteric modulators to treat the disease states mentioned above. Such studies have advanced two molecules into nine separate clinical trials; a phase one safety study to treat Sickle Cell Anemia and seven phase one and two studies for treatment of brain tumors receiving cranial radiation, for use in cardiopulmonary bypass surgery and for treatment of chronic effort angina. The later molecule, RSR-13 is now in phase three clinical trials for treatment of metastatic brain cancer.
Dr. Abraham is also an Affiliate Professor in the Departments of Pharmacology and Toxicology, Biomedical Engineering, Physics, and Biochemistry and Molecular Biophysics. He is founder of a new biotechnology company, Allos Therapeutics Inc., offices located in Denver Colorado and laboratories in the Biotechnology Research Park, Richmond, VA. He is also cofounder of EduSoft LC a new software company that specializes in Drug Design software. Dr. Abraham is editor in chief of the 6th edition of Burger's Medicinal Chemistry. He was appointed by the Governor of the Commonwealth of Virginia to be a member of the Alzheimer's Disease and Related Disorders Commission and is a member of the Governor's Virginia Research and Technology Advisory Commission 2001-2004. Dr. Abraham was the general chair of the American Chemical Society's 26th National Medicinal Chemistry Symposium held in Richmond, June 14-18, 1998. He was awarded The Virginia Section of the American Chemical Society Industrial Innovator for 2001 (Biomedical Software), the Virginia Biotechnology Association's Educator of the Year Award 2000 and Virginia's Outstanding Scientist of the Year for 1999. Recently Dr. Abraham was notified that he is the American Association of Colleges of Pharmacy 2002 Paul R. Dawson Biotechnology Award winner sponsored by Amgen Inc. (July 16, 2002). Dr. Abraham also recently co-founded a third company (kSERO Inc.) that focuses on pre elementary and elementary science education in the life sciences that integrates learning with game playing.