Oncogenomics: Molecular Approaches to Cancer

Copyright © 2004 John Wiley & Sons, Inc. All rights reserved.

Oncogenomics: Molecular Approaches to Cancer

Editor(s): Charles Brenner, David Duggan

Published Online: 28 JAN 2005

Print ISBN: 9780471225928

Online ISBN: 9780471476658

DOI: 10.1002/047147665X

About this Book

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About The Product

This book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xvi)

  2. Part I: Introduction

    1. At the Precarious Cusp of Oncogenomics (pages 1–13)

      Charles Brenner

  3. Part II: Molecular Profiling in Cancer: DNA, RNA, and Protein

    1. Genome-Wide Searches for Mutations in Human Cancer (pages 15–35)

      Michael R. Stratton, P. Andrew Futreal and Richard Wooster

    1. Molecular Cytogenetics: Increasing Resolution Using Array-Based CGH (pages 37–55)

      Anne Kallioniemi

    1. SNPs and Functional Polymorphisms in Cancer (pages 57–75)

      Penelope E. Bonnen and David L. Nelson

    1. Expression Profiling of Breast Cancer: From Molecular Portraits to Clinical Utility (pages 77–100)

      Therese Sorlie, Anne-Lise Borresen-Dale, Per E. Lonning, Patrick O. Brown and David Botstein

    1. Classifying Hereditary Cancers and Phenocopies of Hereditary Cancers Using Expression Arrays (pages 101–116)

      Mary B. Daly, Alicia Parlanti and David Duggan

    1. Linking Drugs and Genes: Pharmacogenomics, Pharmacoproteomics, Bioinformatics, and the NCI-60 (pages 117–137)

      John N. Weinstein

    1. Tissue Microanalysis: Profiling Cancer Stages (pages 139–156)

      Michael A. Tangrea and Michael R. Emmert-Buck

    1. Proteomics in Bladder Cancer (pages 157–184)

      Julio E. Celis, Irina Gromova, Fritz Rank and Pavel Gromov

  11. Part III: Model Systems

    1. Chemical and Genetic Methods to Validate Targets in Nonmammalian Organisms (pages 185–197)

      Tia M. Maiolatesi and Charles Brenner

    1. Mouse Models of Cancer (pages 199–253)

      Debrah M. Thompson, Louise van der Weyden, Patrick J. Biggs, Yeun-Jun Chung and Allan Bradley

    1. Genome-Wide Modifier Screens: How the Genetics of Cancer Penetrance May Shape the Future of Prevention and Treatment (pages 255–290)

      Linda D. Siracusa, Karen A. Silverman, Revati Koratkar, Marina Markova and Arthur M. Buchberg

  14. Part IV: Molecularly Targeted Drugs

    1. Protein Kinases as Targets in Cancer Therapy: Validated and Emerging Approaches (pages 291–315)

      Paul Nghiem, Yong-son Kim and Stuart L. Schreiber

    1. Ras Superfamily-Directed Compounds (pages 317–339)

      George C. Prendergast

    1. Clinomics: Postgenomic Cancer Care (pages 341–358)

      Daniel D. Von Hoff, Haiyong Han and David Bearss

  17. Part V: Conclusion

    1. Oncogenomics and the NCI Director's Vision for 2015 (pages 359–363)

      Andrew C. von Eschenbach

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      Index (pages 365–382)

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