Analysis and Purification Methods in Combinatorial Chemistry, Volume 163

Analysis and Purification Methods in Combinatorial Chemistry, Volume 163

Editor(s): Bing Yan

Published Online: 20 JAN 2004

Print ISBN: 9780471269298

Online ISBN: 9780471531975

DOI: 10.1002/0471531979

Series Editor(s): J. D. Winefordner

About this Book

Quality measurement, control, and improvement in combinatorial chemistry
Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable."
To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering:
* Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis
* High-throughput analytical methods used to analyze the quality of libraries
* High-throughput purification techniques
* Analytical methods applied in post-synthesis and post-purification stages
Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.
This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

Table of contents

    1. You have free access to this content
    2. Chapter 5

      Multivariate Tools for Real-Time Monitoring and Optimization of Combinatorial Materials and Process Conditions (pages 87–123)

      Radislav A. Potyrailo, Ronald J. Wroczynski, John P. Lemmon, William P. Flanagan and Oltea P. Siclovan

    3. Chapter 6

      Mass Spectrometry and Soluble Polymeric Support (pages 125–135)

      Christine Enjalbal, Frederic Lamaty, Jean Martinez and Jean-Louis Aubagnac

    4. Chapter 17

      High-Throughput Determination of Log D Values by LC/MS Method (pages 435–455)

      Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt and James J. Bao

    5. You have free access to this content
    6. You have free access to this content