Molecular Cancer Therapeutics: Strategies for Drug Discovery and Development

Molecular Cancer Therapeutics: Strategies for Drug Discovery and Development

Editor(s): George C. Prendergast

Published Online: 28 JAN 2005

Print ISBN: 9780471432029

Online ISBN: 9780471656166

DOI: 10.1002/047165616X

About this Book

Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development.
This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.

Table of contents

    1. You have free access to this content
    2. Chapter 5

      Applications and Issues for Tissue Arrays in Target and Drug Discovery (pages 73–90)

      Eric Jonasch, Kim-Anh Do, Christopher Logothetis and Timothy J. McDonnell

    3. Chapter 7

      Drug Screening: Assay Development Issues (pages 119–140)

      Steven S. Carroll, James Inglese, Shi-Shan Mao and David B. Olsen

    4. Chapter 13

      Clinical Development Issues (pages 287–306)

      Steven D. Averbuch, Michael K. Wolf, Basil F. El-Rayes and Patricia M. LoRusso

    5. You have free access to this content