Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs

Copyright © 2003 John Wiley & Sons, Inc.

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs

Author(s): Rodney J. Y. Ho, Milo Gibaldi

Published Online: 29 OCT 2004

Print ISBN: 9780471206903

Online ISBN: 9780471704218

DOI: 10.1002/0471704210

About this Book

Product Information

About The Product

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs defines biotechnology from the perspective of pharmaceuticals. The first section focuses on the process of transforming a biologic macromolecule into a therapeutic agent, while the second section provides a brief overview of each class of macromolecule with respect to physiological role and clinical application. Additional detail is also provided in the second section for each FDA approved, recombinantly derived biopharmaceutical for each category of macromolecule. The final section looks to the future and the new advances that will enhance our ability to develop new macromolecules into effective biopharmaceuticals. This last section discusses various drug delivery strategies while also describing gene and cell therapy strategies.

Table of contents

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      Frontmatter (pages i–xvii)

  2. Part I: Transforming Proteins and Genes into Therapeutics

    1. Chapter 1

      Introduction to Biopharmaceuticals (pages 1–9)

    2. Chapter 2

      Comparative Drug Development of Proteins and Genes versus Small Molecules (pages 11–20)

    3. Chapter 3

      Biotechnology Industry Perspective on Drug Development (pages 21–34)

    4. Chapter 4

      Biopharmaceutical Technologies and Processes in Drug Development (pages 35–95)

    5. Chapter 5

      Pharmacology, Toxicology, Therapeutic Dosage Formulations, and Clinical Response (pages 97–123)

  3. Part II: Therapeutics Based on Biotechnology

    1. Chapter 6

      Hematopoietic Growth Factors and Coagulation Factors (pages 125–159)

    2. Chapter 7

      Interferons and Cytokines for Anti-Infective and Cancer Therapy (pages 161–208)

    3. Chapter 8

      Hormones (pages 209–243)

    4. Chapter 9

      Enzymes (pages 245–269)

    5. Chapter 10

      Antibodies and Derivatives (pages 271–311)

    6. Chapter 11

      Vaccines (pages 313–329)

    7. Chapter 12

      Other Products: Monographs (pages 331–335)

  4. Part III: Future Directions

    1. Chapter 13

      Advanced Drug Delivery (pages 337–380)

    2. Chapter 14

      Individualization of Drug Regimens: Integration of Pharmacokinetic and Pharmacogenetic Principles in Drug Therapy (pages 381–400)

    3. Chapter 15

      Gene and Cell Therapy (pages 401–426)

    4. Chapter 16

      Integration of Discovery and Development: The Role of Genomics and Proteomics (pages 427–444)

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      Appendix I: Dosage Form, Pharmacokinetics and Disposition Data (pages 445–466)

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      Appendix II: Molecular Characteristic and Therapeutic Use (pages 467–493)

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      Appendix III: Nomenclature of Biotechnology Products (pages 495–498)

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      Appendix IV: Synonyms of Trade, Common, and Scientific Names (pages 499–525)

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      Appendix V: Other Information Tables (pages 527–538)

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      Index (pages 539–556)

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