Structural Bioinformatics, Volume 44

Structural Bioinformatics, Volume 44

Editor(s): Philip E. Bourne, Helge Weissig

Published Online: 28 JAN 2005

Print ISBN: 9780471202004

Online ISBN: 9780471721208

DOI: 10.1002/0471721204

About this Book

From the Foreword?
"[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery."

This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies.

Table of contents

    1. You have free access to this content
    1. You have free access to this content
  1. Part I: Introduction

    1. Chapter 3

      Fundamentals of DNA and RNA Structure (pages 41–73)

      Stephen Neidle, Bohdan Schneider and Helen M. Berman

    2. Chapter 5

      Macromolecular Structure Determination by NMR Spectroscopy (pages 89–113)

      John L. Markley, Eldon L. Ulrich, William M. Westler and Brian F. Volkman

  2. Part II: Data Representation and Databases

    1. Chapter 10

      The Nucleic Acid Database (pages 199–216)

      Helen M. Berman, John D. Westbrook, Zukang Feng, Lisa Iype, Bohdan Schneider and Christine Zardecki

  3. Part III: Comparative Features

    1. Chapter 13

      The Cath Domain Structure Database (pages 249–271)

      Christine A. Orengo, Frances M. G. Pearl and Janet M. Thornton

  4. Part IV: Structure and Functional Assignment

    1. Chapter 19

      Inferring Protein Function from Structure (pages 387–407)

      Gail J. Bartlett, Todd Annabel E. and Janet M. Thornton

  5. Part V: Protein Interactions

  6. Part VI: Proteins as Drug Targets

    1. Chapter 22

      Principles and Methods of Docking and Ligand Design (pages 441–476)

      Jennifer Krumrine, Florian Raubacher, Natasja Brooijmans and Irwin Kuntz

  7. Part VII: Structure Prediction

    1. Chapter 25

      Homology Modeling (pages 509–523)

      Elmar Krieger, Sander B. Nabuurs and Gert Vriend

    2. Chapter 27

      Ab Initio Methods (pages 547–557)

      Dylan Chivian, Timothy Robertson, Richard Bonneau and David Baker

  8. Part VIII: The Future

    1. Chapter 29

      Structural Genomics (pages 589–612)

      Stephen K. Burley and Jeffrey B. Bonanno

    1. You have free access to this content