Drug Discovery Handbook

Copyright © 2005 John Wiley & Sons, Inc.

Drug Discovery Handbook

Editor(s): Shayne Cox Gad

Published Online: 27 JAN 2005

Print ISBN: 9780471213840

Online ISBN: 9780471728788

DOI: 10.1002/0471728780

About this Book

Product Information

About The Product

The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.

This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including:

  • Genomics, proteomics, high-throughput screening, and systems biology
  • Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more
  • Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xix)

    2. Introduction: Drug Discovery in the 21st Century (pages 1–10)

      Shayne Cox Gad

    3. Chapter 1

      Natural Products (pages 11–72)

      Charles B. Spainhour

    4. Chapter 2

      Cancer Cell Proteomics Using Molecular Aptamers (pages 73–85)

      Weihong Tan, Zehui Cao, Dihua Shangguan, Ying Li, Zhiwen Tang, Prabodhika Mallikratchy and Hui Chen

    5. Chapter 3

      Molecular Similarity Methods and QSAR Models as Tools for Virtual Screening (pages 87–122)

      Jürgen Bajorath

    6. Chapter 4

      Systems Biology: Applications in Drug Discovery (pages 123–183)

      Sean Ekins, Andrej Bugrim, Yuri Nikolsky and Tatiana Nikolskaya

    7. Chapter 5

      High-Throughput Flow Cytometry (pages 185–226)

      Larry A. Sklar, Peter C. Simons, Anna Waller, Sean M. Biggs, Susan M. Young, Marius Olah, Cristian Bologa, Tudor I. Oprea, Eric R. Prossnitz and Bruce S. Edwards

    8. Chapter 6

      Combining NMR Spectral Information with Associated Structural Features to Form Computationally Nonintensive, Rugged, and Objective Models of Biological Activity (pages 227–286)

      Richard D. Beger, Dan A. Buzatu and Jon G. Wilkes

    9. Chapter 7

      Using Microsoft Excel® as a Laboratory Data Management Tool (pages 287–335)

      A. Erik Rubin, Mark F. Russo and William Neil

    10. Chapter 8

      Age of Regulation (pages 337–351)

      Sandy Weinberg and Gerald J. Whartenby

    11. Chapter 9

      Simultaneous Screening of Multiple Cell Lines Using the CellCard System (pages 353–372)

      Oren E. Beske

    12. Chapter 10

      Protein X-ray Crystallography in Drug Discovery (pages 373–455)

      Peter Nollert, Michael D. Feese, Bart L. Staker and Hidong Kim

    13. Chapter 11

      Biological and Chemistry Assays Available During Drug Discovery and Developability Assessment (pages 457–482)

      Duane B. Lakings

    14. Chapter 12

      Strategies and Methods in Monitoring and Targeting Protein–Protein Interactions (pages 483–557)

      Arianna Loregian and Giorgio Palù

    15. Chapter 13

      High-Throughput Screening: Evolution of Technology and Methods (pages 559–602)

      Martyn N. Banks, Angela M. Cacace, Jonathan O'Connell and John G. Houston

    16. Chapter 14

      Metal-Enhanced Fluorescence: Application to High-Throughput Screening and Drug Discovery (pages 603–666)

      Kadir Aslan, Ignacy Gryczynski, Joanna Malicka, Joseph R. Lakowicz and Chris D. Geddes

    17. Chapter 15

      Methods for the Design and Analysis of Replicate-Experiment Studies to Establish Assay Reproducibility and the Equivalence of Two Potency Assays (pages 667–688)

      Brian J. Eastwood, Amy K. Chesterfield, Mary C. Wolff and Christian C. Felder

    18. Chapter 16

      Coupled Luminescent Methods in Drug Discovery: 3-Min Assays for Cytotoxicity and Phosphatase Activity (pages 689–731)

      Michael J. Corey and Robert J. Kinders

    19. Chapter 17

      Design and Pharmaceutical Applications of Prodrugs (pages 733–796)

      Tomi Järvinen, Jarkko Rautio, Mar Masson and Thorsteinn Loftsson

    20. Chapter 18

      GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders (pages 797–907)

      Ulf Madsen, Hans Bräuner-Osborne, Jeremy R. Greenwood, Tommy N. Johansen, Povl Krogsgaard-Larsen, Tommy Liljefors, Mogens Nielsen and Bente Frølund

    21. Chapter 19

      Cardiac Sarcolemmal ATP-Sensitive Potassium Channel Antagonists: Novel Ischemia-Selective Antiarrhythmic Agents (pages 909–935)

      George E. Billman

    22. Chapter 20

      Factors Influencing the Efficacy of Mediator-Specific Anti-Inflammatory, Glucocorticoid, and Anticoagulant Therapies for Sepsis (pages 937–959)

      Peter C. Minneci, Katherine J. Deans, Michael Haley, Xizhong Cui, Charles Natanson and Peter Q. Eichacker

    23. Chapter 21

      Combinatorial Chemistry in the Drug Discovery Process (pages 961–1011)

      Nathan T. Ross, Brian R. McNaughton and Benjamin L. Miller

    24. Chapter 22

      Herbal Medicines and Animal Models of Gastrointestinal Diseases (pages 1013–1035)

      C.H. Cho and J.K.S. Ko

    25. Chapter 23

      Endocrine and Metabolic Agents (pages 1037–1103)

      Brian L. Furman

    26. Chapter 24

      Respiratory Viruses (pages 1105–1134)

      Paul D. Olivo

    27. Chapter 25

      Strategies in the Design of Antiviral Drugs (pages 1135–1190)

      Erik de Clercq and Piet Herdewijn

    28. Chapter 26

      Protein Kinase Inhibitors Drug Discovery (pages 1191–1257)

      Keykavous Parang and Gongqin Sun

    29. Chapter 27

      RNA-Based Therapies (pages 1259–1308)

      Steve Pascolo

    30. Chapter 28

      Novel Imaging Agents for Molecular MR Imaging of Cancer (pages 1309–1341)

      Dmitri Artemov and Zaver M. Bhujwalla

    31. Chapter 29

      Targets and Approaches for Cancer Drug Discovery (pages 1343–1373)

      Susan L. Mooberry

    32. You have free access to this content
      Index (pages 1375–1471)

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