Nutritional Genomics: Discovering the Path to Personalized Nutrition

Nutritional Genomics: Discovering the Path to Personalized Nutrition

Editor(s): Jim Kaput, Raymond L. Rodriguez

Published Online: 10 MAY 2006

Print ISBN: 9780471683193

Online ISBN: 9780471781790

DOI: 10.1002/0471781797

About this Book

The definitive guide to the basic principles and latest advances in Nutritional Genomics


Though still in its infancy, nutritional genomics, or "nutrigenomics," has revealed much about the complex interactions between diet and genes. But it is in its potential applications that nutrigenomics promises to revolutionize the ways we manage human health and combat disease in the years ahead. Great progress already has been made in modeling "personalized" nutrition for optimal health and longevity as well as in genotype-based dietary interventions for the prevention, mitigation, or possible cure of a variety of chronic diseases and some types of cancer.

Topics covered include:
* Nutrients and gene expression
* The role of metabolomics in individualized health
* Molecular mechanisms of longevity regulation and calorie restriction
* Green tea polyphenols and soy peptides in cancer prevention
* Maternal nutrition and fetal gene expression
* Genetic susceptibility to heterocyclic amines from cooked foods
* Bioinformatics and biocomputation in nutrigenomics
* The pursuit of optimal diets

Written by an all-star team of experts from around the globe, this volume provides an integrated overview of the cutting-edge field of nutritional genomics. The authors and editors lead an in-depth discussion of the fundamental principles and scientific methodologies that serve as the foundation for nutritional genomics and explore important recent advances in an array of related disciplines. Each self-contained chapter builds upon its predecessor, leading the reader seamlessly from basic principles to more complex scientific findings and experimental designs. Scientific chapters are carefully balanced with those addressing the social, ethical, regulatory, and commercial implications of nutrigenomics.

Table of contents

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    3. Chapter 4

      Metabolomics: Bringing Nutrigenomics to Practice in Individualized Health Assessment (pages 85–104)

      J. Bruce German, Cora J. Dillard, S. Luke Hillyard, Matthew C. Lange, Jennifer T. Smilowitz, Robert E. Ward and Angela M. Zivkovic

    4. Chapter 11

      Nutrient–Gene Interactions Involving Soy Peptide and Chemopreventive Genes in Prostate Epithelial Cells (pages 255–276)

      Mark Jesus M. Magbanua, Kevin Dawson, Liping Huang, Wasyl Malyj, Jeff Gregg, Alfredo Galvez and Raymond L. Rodriguez

    5. Chapter 14

      Genistein and Polyphenols in the Study of Cancer Prevention: Chemistry, Biology, Statistics, and Experimental Design (pages 305–329)

      Stephen Barnes, David B. Allison, Grier P. Page, Mark Carpenter, Gary L. Gadbury, Sreelatha Meleth, Pamela Horn-Ross, Helen Kim and Coral A. Lamartinere

    6. Chapter 19

      Nutrients and Norms: Ethical Issues in Nutritional Genomics (pages 419–434)

      David Castle, Cheryl Cline, Abdallah S. Daar, Charoula Tsamis and Peter A. Singer

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