Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases

Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases

Editor(s): Isabella Dalle-Donne, Andrea Scaloni, D. Allan Butterfield

Published Online: 19 JUN 2006

Print ISBN: 9780471723455

Online ISBN: 9780471973126

DOI: 10.1002/0471973122

Series Editor(s): Dominic M. Desiderio, Nico M. M. Nibbering

About this Book

Methodology and applications of redox proteomics



The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics.

Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including:
* The role of oxidized proteins in various disorders
* Pioneering studies on the development of redox proteomics
* Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications
* The response and regulation of protein oxidation in different cell types
* The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease


Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Table of contents

    1. You have free access to this content
    2. Chapter 2

      The Chemistry of Protein Modifications Elicited by Nitric Oxide and Related Nitrogen Oxides (pages 25–58)

      Douglas D. Thomas, Lisa Ridnour, Sonia Donzelli, Michael Graham Espey, Daniele Mancardi, Jeffery S. Isenberg, Martin Feelisch, David D. Roberts and David A. Wink

    3. Chapter 10

      ICAT (Isotope-Coded Affinity Tag) Approach to Redox Proteomics: Identification and Quantification of Oxidant-Sensitive Protein Thiols (pages 267–285)

      Mahadevan Sethuraman, Mark E. McComb, Hua Huang, Sequin Huang, Tyler Heibeck, Catherine E. Costello and Richard A. Cohen

    4. Chapter 16

      Proteins as Sensitive Biomarkers of Human Conditions Associated with Oxidative Stress (pages 485–525)

      Isabella Dalle-Donne, Ranieri Rossi, Fabrizio Ceciliani, Daniela Giustarini, Roberto Colombo and Aldo Milzani

    5. Chapter 25

      Oxidative Stress and Protein Oxidation in Pre-Eclampsia (pages 813–829)

      Maarten T. M. Raijmakers, Wilbert H. M. Peters, Christianne J. de Groot and Eric A. P. Steegers

    6. Chapter 26

      Involvement of Oxidants in the Etiology of Chronic Airway Diseases: Proteomic Approaches to Identify Redox Processes in Epithelial Cell Signaling and Inflammation (pages 831–876)

      Albert van der Vliet, Niki L. Reynaert, Peter F. Bove, Karina Ckless, Anne-Katrin Greul, Milena Hristova and Yvonne M. Janssen-Heininger

    7. You have free access to this content

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