Microbial Proteomics: Functional Biology of Whole Organisms

Microbial Proteomics: Functional Biology of Whole Organisms

Editor(s): Ian Humphery-Smith, Michael Hecker

Published Online: 27 OCT 2005

Print ISBN: 9780471699750

Online ISBN: 9780471973164

DOI: 10.1002/0471973165

About this Book

Discover important lessons learned about whole organism biology via microbial proteomics

This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization.

Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include:

  • Microbial pathogenesis at the proteome level
  • Whole cell modeling
  • Structural proteomics and computational analysis
  • Biomolecular interactions
  • Physiological proteomics
  • Metabolic reconstruction using proteomics data

While presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed.

Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of genomic sciences, including biochemistry, microbiology, molecular biology, genetics, biomedical and pharmaceutical sciences, biotechnology, and veterinary science.

Table of contents

    1. You have free access to this content
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    3. Chapter 5

      Proteomics of Archaea (pages 57–72)

      Ricardo Cavicchioli, Amber Goodchild and Mark Raftery

    4. Chapter 9

      AMT Tag Approach to Proteomic Characterization of Deinococcus radiodurans and Shewanella oneidensis (pages 113–134)

      Mary S. Lipton, Margaret F. Romine, Matthew E. Monroe, Dwayne A. Elias, Ljiljana Pasa-Tolic, Gordon A. Anderson, David J. Anderson, Jim Fredrickson, Kim K. Hixson, Christophe Masselon, Heather Mottaz, Nikola Tolic and Richard D. Smith

    5. Chapter 12

      Proteomic Survey through Secretome of Bacillus subtilis (pages 179–208)

      Haike Antelmann, Jan Maarten van Dijl, Sierd Bron and Michael Hecker

    6. Chapter 16

      Proteomic Studies of Plant-Pathogenic Oomycetes and Fungi (pages 271–283)

      Catherine R. Bruce, Pieter van West and Laura J. Grenville-Briggs

    7. Chapter 19

      Identification of Protein Candidates for Developing Bacterial Ghost Vaccines against Brucella (pages 363–377)

      Vito G. Delvecchio, Tim Alefantis, Rodolfo A. Ugalde, Diego Comerci, Maria Ines Marchesini, Akbar Khan, Werner Lubitz and Cesar V. Mujer

    8. Chapter 23

      Cellular Kinetic Modeling of the Microbial Metabolism (pages 437–488)

      Igor I. Goryanin, Galina V. Lebedeva, Ekaterina A. Mogilevskaya, Eugeniy A. Metelkin and Oleg V. Demin

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