Drug Targeting: Organ-Specific Strategies, Volume 12

Drug Targeting: Organ-Specific Strategies, Volume 12

Editor(s): Grietje Molema, Dirk K. F. Meijer

Published Online: 11 OCT 2001

Print ISBN: 9783527299898

Online ISBN: 9783527600069

DOI: 10.1002/352760006X

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman

About this Book

How are medicines transported intact through the body to their specific target sites without triggering side effects? The answer is "Drug Targeting".
This thoroughly application-oriented book gives comprehensive answers to this and many other questions that confront scientists daily in chemical, pharmaceutical and medical research. A concise overview of the most important basic theories, modern forms of therapy and molecular biological tools, it represents a comprehensible introduction to the topic. The book then goes on to deal with strategies for target applications, divided according to target site, for example brain, lungs, liver, blood vessels and tumor cells. The third part is devoted to special, modern techniques, from phage display methods, via the use of tissue slices right up to pharmacokinetic modeling. Throughout, the focus remains on the practical aspect and successful application of the method in question, although a glance at what the future holds is also included. A volume that every pharmaceutically oriented research group should own.

Table of contents

    1. You have free access to this content
    2. Chapter 5

      Delivery of Drugs and Antisense Oligonucleotides to the Proximal Tubular Cell of the Kidney Using Macromolecular and Pro-drug Approaches (pages 121–155)

      Marijke Haas, Yukio Kato, R. Folgert G. Haverdings, Frits Moolenaar, Kokichi Suzuki, Dick de Zeeuw, Yuichi Sugiyama and Dirk K. F. Meijer

    3. Chapter 7

      Vascular Endothelium in Inflamed Tissue as a Target for Site Selective Delivery of Drugs (pages 171–197)

      Maaike Everts, Astrid J. Schraa, Lou F. M. H. de Leij, Dirk K. F. Meijer and Grietje Molema

    4. Chapter 9

      Tumour Vasculature Targeting (pages 233–254)

      Daisy W. J. van der Schaft, S. Ramakrishnan, Grietje Molema and Arjan W. Griffioen

    5. Chapter 10

      Phage Display Technology for Target Discovery in Drug Delivery Research (pages 255–273)

      Ricardo Mutuberria, Jan-Willem Arends, Arjan W. Griffioen and Hennie R. Hoogenboom