BioNMR in Drug Research, Volume 16

BioNMR in Drug Research, Volume 16

Editor(s): Oliver Zerbe

Published Online: 4 MAR 2003

Print ISBN: 9783527304653

Online ISBN: 9783527600663

DOI: 10.1002/3527600663

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wuthrich. Edited by a former coworker of Wuthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids.
BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies.
With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.

Table of contents

    1. You have free access to this content
  1. Part I: Basic Techniques

    1. Chapter 1

      Modern Methods for the Expression of Proteins in Isotopically Enriched Form (pages 1–38)

      Heiko Patzelt, Natalie Goto, Hideo Iwai, Kenneth Lundstrom and Erhard Fernholz

  2. Part II: NMR of Biomolecules

  3. Part III: Modern Spectroscopic Techniques

    1. Chapter 9

      Scalar Couplings across Hydrogen Bonds (pages 207–226)

      Andrew J. Dingley, Florence Cordier, Victor A. Jaravine and Stephan Grzesiek

  4. Part IV: Tools for Investigation of Drug – Receptor Complexes and for Ligand Screening

    1. Chapter 14

      Experiments in NMR-Based Screening (pages 321–340)

      Carla Marchioro, Silvia Davalli, Stefano Provera, Markus Heller, Alfred Ross and Hans Senn

  5. Part V: Strategies for Drug Development Using NMR

    1. Chapter 20

      Strategies for Drug Discovery Using NMR (pages 439–457)

      Marcel J. J. Blommers, Andreas Flörsheimer and Wolfgang Jahnke

    2. Chapter 21

      NMR-Based Drug Design: Approaches for Very Large Proteins (pages 459–471)

      Maurizio Pellecchia, Xuemei Huang, David Meininger and Daniel S. Sem