BioNMR in Drug Research, Volume 16
Copyright © 2002 Wiley-VCH Verlag GmbH & Co. KGaA
Editor(s): Oliver Zerbe
Published Online: 4 MAR 2003
Print ISBN: 9783527304653
Online ISBN: 9783527600663
Book Series: Methods and Principles in Medicinal Chemistry
Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
About this Book
The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wuthrich. Edited by a former coworker of Wuthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids.
BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies.
With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.