Apoptosis and Autoimmunity

Copyright © 2003 Wiley-VCH Verlag GmbH & Co. KGaA

Apoptosis and Autoimmunity

Editor(s): Joachim R. Kalden, Martin Herrmann

Published Online: 16 SEP 2004

Print ISBN: 9783527304424

Online ISBN: 9783527601455

DOI: 10.1002/3527601457

About this Book

Product Information

About The Product

This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases.

It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.

Table of contents

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      Front Matter (pages i–xxi)

  2. Part 1: General Features of Apoptosis

    1. Chapter 1

      Apoptosis and Autoimmunity (pages 1–11)

      Keith Elkon

    2. Chapter 2

      Caspase Knockouts: Matters of Life and Death (pages 13–35)

      Saquib Lakhani, Binfeng Lu and Richard A. Flavell

  3. Part 2: Clearance of Apoptotic Cells

    1. Chapter 3

      Anti-Inflammatory and Immunoregulatory Effects of Apoptotic Cells (pages 37–56)

      Reinhard E. Voll, Dr. Dr. Martin Herrmann, Irute Girkontaite, Christian Stach, Wasilis Kolowos and Prof. Dr. Dr. Joachim R. Kalden

    2. Chapter 4

      Complement and Apoptosis (pages 57–78)

      Dror Mevorach

    3. Chapter 5

      Soluble Factors That Bind to Dying Cells Control the Outcome of Corpse Disposal: The Role of Pentraxins, Collectins and Autoantibodies (pages 79–95)

      Patrizia Rovere-Querini

    4. Chapter 6

      The Role of ATP-Binding Cassette Transporters in the Clearance of Apoptotic Cells: A Tale of Two Systems (pages 97–109)

      Véronique Rigot and Giovanna Chimini

    5. Chapter 7

      Innate Immunity and Apoptosis: CD14-Dependent Clearance of Apoptotic Cells (pages 111–131)

      Christopher D. Gregory and Andrew Devitt

  4. Part 3: Autoimmunity Caused by Defective Execution of Apoptosis or Defective Clearance of Apoptotic Cells

    1. Chapter 8

      Autoimmune Lymphoproliferative Syndromes (ALPS) (pages 133–155)

      Frédéric Rieux-Laucat, Françoise Deist and Alain Fischer

    2. Chapter 9

      Infection and Inflammation as Cofactors for Autoimmunity of Systemic Lupus Erythematosus Patients (pages 157–168)

      Hanns-Martin Lorenz

    3. Chapter 10

      Apoptosis in Rheumatoid Arthritis (pages 169–186)

      Yuji Yamanishi and Gary S. Firestein

    4. Chapter 11

      Systemic Lupus Erythematosus (pages 187–204)

      Thomas D. Beyer, Susanne Kuenkele, Udo S. Gaipl, Wasilis Kolowos, Reinhard E. Voll, Irith Baumann, Prof. Dr. Dr. Joachim R. Kalden and Dr. Dr. Martin Herrmann

  5. Part 4: Immunogenicity of Apoptotic Cells

    1. Chapter 12

      Dendritic Cells Pulsed with Apoptotic Tumor Cells as Vaccines (pages 205–226)

      Lars Jenne and Birthe Sauter

    2. Chapter 13

      The Immune Response against Apoptotic Cells (pages 227–242)

      Angelo A. Manfredi

  6. Part 5: “Altered Self” in Dying Cells

    1. Chapter 14

      Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease (pages 243–260)

      Antony Rosen and Livia Casciola-Rosen

    2. Chapter 15

      Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity (pages 261–288)

      Carlos A. Casiano, Christine Molinaro, Sheldon Holder and Xiwei Wu

    3. Chapter 16

      ‘Tissue’ Transglutaminase and Autoimmunity (pages 289–298)

      Alessandra Amendola and Mauro Piacentini

    4. Chapter 17

      Modification of RNA Antigens in Apoptosis (pages 299–315)

      Wolfgang Hueber and Paul J. Utz

  7. Part 6: The Role of DNA Binding Proteins for Systemic Autoimmunity

    1. Chapter 18

      Nucleosomes and Anti-Nucleosome Autoantibodies as Mediators of Glomerular Pathology in Systemic Lupus Erythematosus (pages 317–342)

      Jürgen W. C. Dieker, Johan van der Vlag and Jo H. M. Berden

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      Glossary (pages 343–360)

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      Subject Index (pages 361–381)

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