Small Molecule DNA and RNA Binders: From Synthesis to Nucleic Acid Complexes

Small Molecule DNA and RNA Binders: From Synthesis to Nucleic Acid Complexes

Editor(s): Martine Demeunynck, Christian Bailly, W. David Wilson

Published Online: 6 APR 2004

Print ISBN: 9783527305957

Online ISBN: 9783527601783

DOI: 10.1002/3527601783

About this Book

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

Table of contents

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  1. Part 1: Volume 1

    1. Chapter 1

      Forty Years On (pages 1–17)

      Prof. Michael J. Waring and L. P. G. Wakelin

    2. Chapter 7

      Charge Transport in DNA (pages 146–177)

      Tashica T. Williams and Jacqueline K. Barton

    3. Chapter 12

      Triplex- versus Quadruplex-Specific Ligands and Telomerase Inhibition (pages 315–336)

      Patrizia Alberti, Magali Hoarau, Lionel Guittat, Masashi Takasugi, Paola B. Arimondo, Laurent Lacroix, Martin Mills, Marie-Paule Teulade-Fichou, Dr. Jean-Pierre Vigneron, Jean-Marie Lehn, Patrick Mailliet and Dr. Jean-Louis Mergny

  2. Part 2: Volume 2

    1. Chapter 13

      Design and Analysis of G4 Recognition Compounds (pages 337–359)

      Shozeb Haider, Gary N. Parkinson, Martin A. Read and Prof. Dr. Stephen Neidle

    2. Chapter 14

      Triple Helix-Specific Ligands (pages 360–383)

      Prof. Dr. Keith R. Fox and Richard A. J. Darby

    3. Chapter 25

      The Generation and DNA-Interaction of PBD and CBI Libraries (pages 697–710)

      Alison Hardy, Jane M. Berry, Natalie Brooks-Turner, Philip W. Howard, John. A. Hartley and Dr. David. E. Thurston

    1. You have free access to this content