Protein-Ligand Interactions: From Molecular Recognition to Drug Design

Protein-Ligand Interactions: From Molecular Recognition to Drug Design

Editor(s): H.-J. Böhm, G. Schneider

Published Online: 28 JAN 2005

Print ISBN: 9783527305216

Online ISBN: 9783527601813

DOI: 10.1002/3527601813

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding.

Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed.

An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.

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