Protein Crystallography in Drug Discovery

Protein Crystallography in Drug Discovery

Editor(s): Robert E. Babine, Sherin S. Abdel-Meguid

Published Online: 20 FEB 2004

Print ISBN: 9783527306787

Online ISBN: 9783527601875

DOI: 10.1002/3527601872

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method.
Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included.
A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

Table of contents

    1. You have free access to this content
    2. Chapter 2

      Kinases (pages 47–81)

      Jerry L. Adams, James Veal and Lisa Shewchuk

    3. Chapter 11

      Micro-Crystallization (pages 235–255)

      Carl L. Hansen, Morten Sommer, Kyle Self, James M. Berger and Stephen R. Quake

    4. You have free access to this content