Lipases and Phospholipases in Drug Development: From Biochemistry to Molecular Pharmacology

Lipases and Phospholipases in Drug Development: From Biochemistry to Molecular Pharmacology

Editor(s): Günter Müller, Stefan Petry

Published Online: 28 JAN 2005

Print ISBN: 9783527306770

Online ISBN: 9783527601912

DOI: 10.1002/3527601910

About this Book

Lipases and Phospholipases are key control elements in mammalian metabolism. They share many common features that set them apart from other metabolic enzyme classes, most importantly their association with biological membranes. Their potential as drug targets for the treatment of metabolic diseases is widely recognized, and the first lipase inhibitor drugs have been successfully introduced.
Providing drug developers with a firm foundation for lipase-centered drug design, the editors of this volume have assembled experts from different scientific disciplines to create a comprehensive handbook for all pharmaceutical chemists, biochemists and physiologists working with lipases.
The authors examine fundamental aspects of lipase function in vitro and in vivo, explaining how this knowledge may be used to develop lipase assays. They also treat the physiological roles of lipases in normal and disordered metabolism, as well as strategies to target lipases for the treatment of diabetes, obesity and related disorders. Additional topics include the application of phospholipases for liposome-based drug delivery and their use as diagnostic tools.

Table of contents

    1. You have free access to this content
    2. Chapter 7

      High-throughput Screening of Hormone-sensitive Lipase and Subsequent Computer-assisted Compound Optimization (pages 121–137)

      Dr. Stefan Petry, Karl-Heinz Baringhaus, Karl Schoenafinger, Christian Jung, Horst Kleine and Dr. Günter Müller

    3. Chapter 9

      Digestive Lipases Inhibition: an In vitro Study (pages 155–193)

      Ali Tiss, Nabil Miled, Robert Verger, Youssef Gargouri and Abdelkarim Abousalham

    4. Chapter 10

      Physiology of Gastrointestinal Lipolysis and Therapeutical Use of Lipases and Digestive Lipase Inhibitors (pages 195–229)

      Hans Lengsfeld, Gabrielle Beaumier-Gallon, Henri Chahinian, Alain De Caro, Robert Verger, René Laugier and Frédéric Carrière

    5. You have free access to this content