Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Editor(s): Hans-Ulrich Blaser, Elke Schmidt

Published Online: 13 JAN 2004

Print ISBN: 9783527306312

Online ISBN: 9783527602155

DOI: 10.1002/3527602151

About this Book

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Edited by two of the experts in the field, the central aim is to show organic chemists working in process development that enantioselective catalysis is suitable for the large-scale production of enantioenriched intermediates. In so doing, it is equally a source of information and inspiration for academic research, and, with its contribution by Noble prizewinner W. S. Knowles, will also heighten the status of industrial catalyst specialists working in the exciting field of enantioselective catalysis.

Some 25 contributions from top industrial researchers around the world present case studies on the development of the widest possible range of large-scale enantioselective processes, featuring stereoselective production processes of fine-chemicals, agrochemicals and pharmaceuticals. Clearly structured according to the nature of the task, this handbook adopts a problem-driven approach such that readers can easily find how colleagues have dealt with a similar situation.

Table of contents

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    1. Introduction (pages 1–19)

      Dr. Hans-Ulrich Blaser and Dr. Elke Schmidt

  1. Part I: New Processes for Existing Active Compounds

    1. Chapter 3

      The Chiral Switch of Metolachlor: The Development of a Large-Scale Enantioselective Catalytic Process (pages 55–70)

      Dr. Hans-Ulrich Blaser, Reinhard Hanreich, Hans-Dieter Schneider, Felix Spindler and Beat Steinacher

    2. Chapter 5

      Comparison of Four Technical Syntheses of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate (pages 91–103)

      Dr. Hans-Ulrich Blaser, Marco Eissen, Pierre F. Fauquex, Konrad Hungerbühler, Dr. Elke Schmidt, Gottfried Sedelmeier and Martin Studer

  2. Part II: New Catalysts for Existing Active Compounds

    1. Chapter 2

      Industrialization Studies of the Jacobsen Hydrolytic Kinetic Resolution of Epichlorohydrin (pages 165–199)

      Larbi Aouni, Karl E. Hemberger, Serge Jasmin, Hocine Kabir, Jay F. Larrow, Isidore Le-Fur, Philippe Morel and Thierry Schlama

  3. Part III: Adaptation of Existing Catalysts for Important Building Blocks

    1. Chapter 2

      The Application of DuPHOS Rhodium(I) Catalysts for Commercial Scale Asymmetric Hydrogenation (pages 269–282)

      Christopher J. Cobley, Nicholas B. Johnson, Ian C. Lennon, Raymond McCague, James A. Ramsden and Antonio Zanotti-Gerosa

    2. Chapter 3

      Liberties and Constraints in the Development of Asymmetric Hydrogenations on a Technical Scale (pages 283–308)

      John F. McCarrity, Walter Brieden, Rudolf Fuchs, Hans-Peter Mettler, Beat Schmidt and Oleg Werbitzky

  4. Part IV: Processes for New Chemical Entities (NCE)

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