Carbohydrate-Based Drug Discovery

Copyright © 2003 Wiley-VCH Verlag GmbH & Co. KGaA

Carbohydrate-Based Drug Discovery

Editor(s): Chi-Huey Wong

Published Online: 28 JAN 2005

Print ISBN: 9783527306329

Online ISBN: 9783527602438

DOI: 10.1002/3527602437

About this Book

Product Information

About The Product

This handbook presents the latest knowledge on carbohydrate chemistry and biochemistry so as to exploit the full potential of this diverse compound class for the development of novel active substances. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following:

  • Chemical synthesis of carbohydrates
  • Carbohydrate biosynthesis and metabolism
  • Carbohydrate analysis
  • Cellular functions of carbohydrates
  • Development of carbohydrate-based drugs

Table of contents

    1. You have free access to this content
      Front Matter (pages 1–xxv)

    2. Chapter 1

      Synthetic Methodologies (pages 1–36)

      Chikako Saotome and Osamu Kanie

    3. Chapter 2

      Complex Carbohydrate Synthesis (pages 37–54)

      Makoto Kiso, Hideharu Ishida and Hiromune Ando

    4. Chapter 3

      The Chemistry of Sialic Acid (pages 55–102)

      Geert-Jan Boons and Alexei V. Demchenko

    5. Chapter 4

      Solid-Phase Oligosaccharide Synthesis (pages 103–127)

      Peter H. Seeberger

    6. Chapter 5

      Solution and Polymer-Supported Synthesis of Carbohydrates (pages 129–136)

      Shin-Ichiro Nishimura

    7. Chapter 6

      Enzymatic Synthesis of Oligosaccharides (pages 137–167)

      Jianbo Zhang, Jun Shao, Prezemk Kowal and Peng George Wang

    8. Chapter 7

      Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology (pages 169–214)

      Oliver Seitz

    9. Chapter 8

      Synthesis of Complex Carbohydrates: Everninomicin (pages 215–252)

      K. C. Nicolaou, Helen J. Mitchell and Scott A. Snyder

    10. Chapter 9

      Chemical Synthesis of Asparagine-Linked Glycoprotein Oligosaccharides: Recent Examples (pages 253–280)

      Yukishige Ito and Ichiro Matsuo

    11. Chapter 10

      Chemistry and Biochemistry of Asparagine-Linked Protein Glycosylation (pages 281–303)

      Barbara Imperiali and Vincent W.-F. Tai

    12. Chapter 11

      Conformational Analysis of C-Glycosides and Related Compounds: Programming Conformational Profiles of C- and O-Glycosides (pages 305–340)

      Peter G. Goekjian, Alexander Wei and Yoshito Kishi

    13. Chapter 12

      Synthetic Lipid A Antagonists for Sepsis Treatment (pages 341–355)

      William J. Christ, Lynn D. Hawkins, Michael D. Lewis and Yoshito Kishi

    14. Chapter 13

      Polysialic Acid Vaccines (pages 357–380)

      Harold J. Jennings

    15. Chapter 14

      Synthetic Carbohydrate-Based Vaccines (pages 381–406)

      Stacy J. Keding and Samuel J. Danishefsky

    16. Chapter 15

      Chemistry, Biochemistry, and Pharmaceutical Potentials of Glycosaminoglycans and Related Saccharides (pages 407–439)

      Tasneem Islam and Robert J. Linhardt

    17. Chapter 16

      A New Generation of Antithrombotics Based on Synthetic Oligosaccharides (pages 441–459)

      Maurice Petitou and Jean-Marc Herbert

    18. Chapter 17

      Sequencing of Oligosaccharides and Glycoproteins (pages 461–482)

      Stuart M. Haslam, Kay-Hooi Khoo and Anne Dell

    19. Chapter 18

      Preparation of Heterocyclic 2-Deoxystreptamine Aminoglycoside Analogues and Characterization of Their Interaction with RNAs by Use of Electrospray Ionization Mass Spectrometry (pages 483–499)

      Richard H. Griffey, Steven A. Hofstadler and Eric E. Swayze

    20. Chapter 19

      Glycosylation Analysis of a Recombinant P-Selectin Antagonist by High-pH Anion-Exchange Chromatography with Pulsed Electrochemical Detection (HPAEC/PED) (pages 501–516)

      Mark R. Hardy and Richard J. Cornell

    21. Chapter 20

      Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans (pages 517–539)

      Ram Sasisekharan, Zachary Shriver, Mallik Sundaram and Ganesh Venkataraman

    22. Chapter 21

      Thermodynamic Models of the Multivalency Effect (pages 541–574)

      Pavel I. Kitov and David R. Bundle

    23. Chapter 22

      Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes (pages 575–608)

      Laura L. Kiessling, Jason K. Pontrello and Michael C. Schuster

    24. Chapter 23

      Glycosyltransferase Inhibitors (pages 609–659)

      Karl-Heinz Jung and Richard R. Schmidt

    25. Chapter 24

      RNA-Aminoglycoside Interactions (pages 661–683)

      Haim Weizman and Yitzhak Tor

    26. Chapter 25

      Glycosylated Natural Products (pages 685–711)

      Jon S. Thorson and Thomas Vogt

    27. Chapter 26

      Novel Enzymatic Mechanisms in the Biosynthesis of Unusual Sugars (pages 713–745)

      Alexander Wong, Xuemei He and Hung-Wen Liu

    28. Chapter 27

      Neoglycolipids: Identification of Functional Carbohydrate Epitopes (pages 747–760)

      Ten Feizi, Alexander M. Lawson and Wengang Chai

    29. Chapter 28

      A Preamble to Aglycone Reconstruction for Membrane-Presented Glycolipid Mimics (pages 761–779)

      Murugesapillai Mylvaganam and Clifford A. Lingwood

    30. Chapter 29

      Small Molecule Inhibitors of the Sulfotransferases (pages 781–801)

      Dawn E. Verdugo, Lars C. Pedersen and Carolyn R. Bertozzi

    31. Chapter 30

      Carbohydrate-Based Treatment of Cancer Metastasis (pages 803–829)

      Reiji Kannagi

    32. Chapter 31

      N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-Influenza Agents (pages 831–861)

      Robin Thomson and Mark von Itzstein

    33. Chapter 32

      Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents – The Biochemically Engineered N-Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine (pages 863–873)

      Rüdiger Horstkorte, Oliver T. Keppler and Werner Reutter

    34. Chapter 33

      Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents – Glycosidated Phospholipids as a New Type of Antiproliferative Agents (pages 875–882)

      Kerstin Danker, Annette Fischer and Werner Reutter

    35. Chapter 34

      Glycoside Primers and Inhibitors of Glycosylation (pages 883–898)

      Jillian R. Brown, Mark M. Fuster and Jeffrey D. Esko

    36. Chapter 35

      Carbohydrate-Based Drug Discovery in the Battle against Bacterial Infections: New Opportunities Arising from Programmable One-Pot Oligosaccharide Synthesis (pages 899–932)

      Thomas K. Ritter and Prof. Dr. Chi-Huey Wong

    37. You have free access to this content
      Subject Index (pages 933–947)

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