Molecular Biology in Medicinal Chemistry

Molecular Biology in Medicinal Chemistry

Editor(s): Theodor Dingermann, Dieter Steinhilber, Gerd Folkers

Published Online: 28 JAN 2005

Print ISBN: 9783527304318

Online ISBN: 9783527602667

DOI: 10.1002/3527602666

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods.
With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

Table of contents

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  1. Part I: Molecular Targets

    1. Chapter 1

      Cellular Assays in Drug Discovery (pages 1–47)

      Dr. Hugo Albrecht, Dr. Daniela Brodbeck-Hummel, Dr. Michael Hoever, Dr. Beatrice Nickel and Dr. Urs Regenass

    2. Chapter 2

      Gene Knockout Models (pages 48–72)

      Prof. Dr. Peter Ruth and Dr. Matthias Sausbier

  2. Part II: Synthesis

    1. Chapter 6

      Nucleic Acid Drugs (pages 153–178)

      Prof. Dr. Joachim W. Engels and Dr. Jörg Parsch

  3. Part III: Analysis

    1. Chapter 9

      Nuclear Magnetic Resonance-based Drug Discovery (pages 242–268)

      Dr. Ulrich L. Günther, Dr. Christina Fischer and Prof. Dr. Heinz Rüterjans

    2. Chapter 10

      13C- and 15N- Isotopic Labeling of Proteins (pages 269–299)

      Dr. Christian Klammt, Dr. Frank Bernhard and Prof. Dr. Heinz Rüterjans

  4. Part IV: Kinetics, Metabolism and Toxicology

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