Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials

Copyright © 2002 Wiley-VCH Verlag GmbH

Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials

Editor(s): K. C. Nicolaou, R. Hanko, W. Hartwig

Published Online: 28 JAN 2005

Print ISBN: 9783527305094

Online ISBN: 9783527603039

DOI: 10.1002/3527603034

About this Book

Product Information

About The Product

At long last, the mechanism-based and application-oriented handbook of combinatorial chemistry.

Since its very beginning, research in this field has continued to develop at a rapid rate. Increasingly elegant methods are being invented and an even wider range of possible applications is still being discovered, such that combinatorial chemistry is now an integral part of industrial and academic research.

The high-class editorial team - K. C. Nicolaou of The Scripps Institute and UCSD, and R. Hanko and W. Hartwig from Bayer - ensure comprehensive coverage and top quality contributions. This two-volume work deals with synthetic chemistry in all its forms, applications from life sciences, chemistry and
material sciences, all there is to know about compound library design and synthesis, and, of course, the general basics - making it an indispensable reference for synthetic, organic and medicinal chemists, chemical biologists as well as material scientists.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xxxi)

  2. Part I: General Aspects

    1. Chapter 1

      Combinatorial Chemistry in Perspective (pages 1–9)

      Prof. Dr. K. C. Nicolaou, Dr. R. Hanko and Prof. Dr. W. Hartwig

    2. Chapter 2

      Introduction to Combinatorial Chemistry (pages 10–23)

      David L. Coffen and Joachim E. A. Luithle

    3. Chapter 3

      Solid Phase and Soluble Polymers for Combinatorial Synthesis (pages 24–58)

      Rainer Haag, André Hebel and Jean-François Stumbé

    4. Chapter 4

      Linkers for Solid-Phase Synthesis (pages 59–169)

      Stefan Bräse and Stefan Dahmen

    5. Chapter 5

      Encoding Technologies (pages 170–189)

      Thomas Krämer, Valery V. Antonenko, Reza Mortezaei and Nicolay V. Kulikov

    6. Chapter 6

      Instrumentation for Combinatorial Chemistry (pages 190–224)

      Marcus Bauser and Hubertus Stakemeier

  3. Part II: Synthetic Chemistry

    1. Chapter 7

      Radical Reactions in Combinatorial Chemistry (pages 225–246)

      A. Ganesan and Mukund P. Sibi

    2. Chapter 8

      Nucleophilic Substitution in Combinatorial and Solid-Phase Synthesis (pages 247–269)

      Jan-Gerd Hansel and Stephan Jordan

    3. Chapter 9

      Electrophilic Substitution in Combinatorial and Solid-Phase Synthesis (pages 270–278)

      Jan-Gerd Hansel and Stephan Jordan

    4. Chapter 10

      Elimination Chemistry in the Solution- and Solid-Phase Synthesis of Combinatorial Libraries (pages 279–304)

      Demosthenes Fokas and Carmen Baldino

    5. Chapter 11

      Addition to CC Multiple Bonds (Except for CC Bond Formation) (pages 305–321)

      Adrian L. Smith

    6. Chapter 12

      Addition to Carbon–Hetero Multiple Bonds (pages 322–345)

      Philipp Grosche, Jörg Rademann and Günther Jung

    7. Chapter 13

      Chemistry of the Carbonyl Group (pages 346–368)

      Tobias Wunberg

    8. Chapter 14

      Oxidation Except CC Double Bonds (pages 369–386)

      Henning Steinhagen

    9. Chapter 15

      Reductions in Combinatorial Synthesis (pages 387–439)

      Christopher P. Corrette and Conrad W. Hummel

    10. Chapter 16

      Cycloadditions in Combinatorial and Solid-Phase Synthesis (pages 440–469)

      Markus Albers and Thorsten Meyer

    11. Chapter 17

      Main Group Organometallics (pages 470–491)

      Christopher Kallus

    12. Chapter 18

      Enolates and Related Species in Combinatorial and Solid-Phase Synthesis (pages 492–530)

      Jochen Krüger

    13. Chapter 19

      Solid-Phase Palladium Catalysis for High-Throughput Organic Synthesis (pages 531–584)

      Yasuhiro Uozumi and Tamio Hayashi

    14. Chapter 20

      Olefin Metathesis and Related Processes for CC Multiple Bond Formation (pages 585–609)

      Florencio Zaragoza

  4. Part III: Special Synthetic Topics

    1. Chapter 21

      Solid-Phase Synthesis of Natural Products and Natural Product-Like Libraries (pages 611–642)

      Prof. Dr. K. C. Nicolaou and Jeffrey A. Pfefferkorn

    2. Chapter 22

      Solid-Phase Synthesis of Heterocyclic Systems (Heterocycles Containing One Heteroatom) (pages 643–684)

      Roland E. Dolle

    3. Chapter 23

      Multicomponent Reactions (pages 685–705)

      Arounarith Tuch and Stefan Wallé

    4. Chapter 24

      Strategies for Creating the Diversity of Oligosaccharides (pages 706–722)

      Pamela Sears and Chi-Huey Wong

  5. Part IV: Molecular Design and Combinatorial Compound Libraries

    1. Chapter 25

      Design Criteria (pages 723–742)

      Josef Pernerstorfer

    2. Chapter 26

      Estimation of Physicochemical and ADME Parameters (pages 743–760)

      Michael W. Härter, Jörg Keldenich and Walter Schmitt

    3. Chapter 27

      Virtual Compound Libraries and Molecular Modeling (pages 761–783)

      Roger M. Brunne, Gerhard Hessler and Ingo Muegge

    4. Chapter 28

      Erythropoietin Sensitizer – A Case Study (pages 784–805)

      Berthold Hinzen, Gabriele Bräunlich, Christoph Gerdes, Thomas Krämer, Klemens Lustig, Ulrich Nielsch, Michael Sperzel and Josef Pernerstorfer

    5. Chapter 29

      Estimation of Stability and Shelf Life for Compounds, Libraries, and Repositories in Combination with Systematic Discovery of New Rearrangement Pathways (pages 806–828)

      Ferenc Darvas, György Dorman, Tamás Karancsi, Tamás Nagy and István Bágyi

  6. Part V: Novel Applications of Combinatorial Chemistry

    1. Chapter 30

      Concepts of Combinatorial Chemistry in Process Development (pages 829–863)

      Markus Eckert and Ulrich Notheis

    2. Chapter 31

      High-Throughput Screening Applied to Process Development (pages 864–884)

      Oliver Brümmer, Bernd Jandeleit, Tetsuo Uno and W. Henry Weinberg

    3. Chapter 32

      Combinatorial Methods in Catalysis (pages 885–990)

      Bill Archibald, Oliver Brümmer, Martin Devenney, Sasha Gorer, Bernd Jandeleit, Tetsuo Uno, W. Henry Weinberg and Thomas Weskamp

    4. Chapter 33

      Diversity-Based Identification of Efficient Homochiral Organometallic Catalysts for Enantioselective Synthesis (pages 991–1016)

      Amir H. Hoveyda

    5. Chapter 34

      Combinatorial Aspects of Materials Science (pages 1017–1062)

      Bill Archibald, Oliver Brümmer, Martin Devenney, Daniel M. Giaquinta, Bernd Jandeleit, W. Henry Weinberg and Thomas Weskamp

    6. Chapter 35

      Reprogramming Combinatorial Biology for Combinatorial Chemistry (pages 1063–1097)

      Sean V. Taylor

    1. You have free access to this content
      Index (pages 1099–1114)

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