Carbohydrate Mimics: Concepts and Methods

Carbohydrate Mimics: Concepts and Methods

Editor(s): Yves Chapleur

Published Online: 28 JAN 2005

Print ISBN: 9783527295265

Online ISBN: 9783527603237

DOI: 10.1002/3527603239

About this Book

Apart from the various functions of carbohydrates in natural processes they are important building blocks for drugs, especially antibiotics. In addition, carbohydrates are considered as important structures in the immunological recognition process of the antigen-antibody reaction.

The modification of the structure and thereby the chemistry of substrates is a common procedure in nature. This naturally occurring process is reflected in the concept of molecular mimicry, which has become a useful approach in drug discovery. The search for carbohydrate analogues that exhibit better binding activity, biological activity, and stability began with the synthesis of azasugars. A lot of structural modifications around the anomeric center of carbohydrates has been achieved over the last decade, and these are summarized in terms of the different chemical and biological aspects of carbohydrate mimics in one part of this book. In addition to the well established fields of C-glycosides, azasugars and carbasugars the other part of the book focusses on outstanding achievements in carbohydrate mimic research.

Everybody who is active in carbohydrate research or is interested in moving into this exciting field will benefit from this up-to-date source of informations. The leading experts in this field describe their scientific approaches to real interdisciplinary puzzles. This book should be an inspiration to scientists in organic, medicinal chemistry, biochemistry, and biology.

Table of contents

    1. You have free access to this content
    2. Chapter 21

      From Glycosaminoglycans to Heparinoid Mimetics with Antiproliferative Activity (pages 417–431)

      H. P. Wessel, A. Chucholowski, J. Fingerle, N. Iberg, H. P. Märki, R. Müller, M. Pech, M. Pfister-Downar, M. Rouge, G. Schmid and T. Tschopp

    3. Chapter 22

      Conduritols and Analogues as Insulin Modulators (pages 433–441)

      D.C. Billington, F. Perron-Sierra, I. Picard, S. Beaubras, J. Duhault, J. Espinal and S. Challal

    4. Chapter 25

      Design and Synthesis of Potential Fucosyl Transferase Inhibitors (pages 491–510)

      G. A. van der Marel, B. M. Heskamp, G. H. Veeneman, C. A. A. van Boeckel and J. H. van Boom

    5. You have free access to this content