Handbook of Toxicogenomics: Strategies and Applications

Handbook of Toxicogenomics: Strategies and Applications

Editor(s): Jürgen Borlak

Published Online: 23 MAY 2005

Print ISBN: 9783527303427

Online ISBN: 9783527603718

DOI: 10.1002/3527603719

About this Book

Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies.
The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives.
Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."

Table of contents

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  1. Part 1: Technology Platforms in Toxicogenomics

  2. Part 2: Bioinformatic Tools in Toxicogenomics

    1. Chapter 10

      The Chemical Effects in Biological Systems (CEBS) Knowledge Base (pages 201–232)

      Michael Waters, Gary Boorman, Pierre Bushel, Michael Cunningham, Rick Irwin, Alex Merrick, Kenneth Olden, Richard Paules, James Selkirk, Stanley Stasiewicz, Brenda Weis, Ben van Houten, Nigel Walker, Honghui Wan and Raymond Tennant

    2. Chapter 12

      Databases and Tools for in silico Analysis of Regulation of Gene Expression (pages 253–290)

      Alexander Kel, Olga Kel-Margoulis, Univ.-Prof. Dr. Jürgen Borlak, Dimitry Tchekmenev and Edgar Wingender

    3. Chapter 13

      Systems Biology Applied to Toxicogenomics (pages 291–324)

      Klaus Prank, Matthias Höchsmann, Björn Oleson, Thomas Schmidt, Leila Taher and Dion Whitehead

  3. Part 3: Application of Toxicogenomic: Case Studies

    1. Chapter 17

      Toxicogenomics Applied to Endocrine Disruption (pages 413–433)

      Damian G. Deavall, Jonathan G. Moggs and George Orphanides

    2. Chapter 18

      Toxicogenomics Applied to Teratogenicity Studies (pages 435–469)

      Philip G. Hewitt, Peter-J. Kramer and Univ.-Prof. Dr. Jürgen Borlak

    3. Chapter 21

      Genetic Variability: Implications for Toxicogenomic Research (pages 507–534)

      Gilbert Schönfelder, Dieter Schwarz, Thomas Gerloff, Martin Paul and Ivar Roots

  4. Part 4: The National Toxicogenomic Program/Initiatives

    1. Chapter 25

      The National Toxicogenomics Program (pages 609–621)

      James K. Selkirk, Michael D. Waters and Raymond W. Tennant

  5. Part 5: Point of View from Regulatory Authorities and Ethical Aspects

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