Centrosomes in Development and Disease

Centrosomes in Development and Disease

Editor(s): Erich A. Nigg

Published Online: 17 JUN 2005

Print ISBN: 9783527309801

Online ISBN: 9783527603800

DOI: 10.1002/3527603808

About this Book

Discovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in the role of this organelle in a broader scientific community.

The centrosome controls the number and distribution of microtubules - a major element of the cell cytoskeleton - and hence influences many important cellular functions and properties. These include cell shape, polarity, and motility, as well as the intracellular transport and positioning of various organelles. Of particular interest, centrosome function is critical for chromosome segregation and cell division.

This book is meant to summarize our current knowledge of the structure, function and evolution of microtubule organizing centers, primarily centrosomes. Emphasis is on the role of these organelles in development and disease (particularly cancer).

Table of contents

    1. You have free access to this content
    1. You have free access to this content
  1. Part I: Microtubule Organization and Dynamics

    1. Chapter 3

      Microtubule Nucleation (pages 27–41)

      Michelle Moritz, Luke M. Rice and David A. Agard

  2. Part II: The Integration of Centrosome and Chromosome Cycles

    1. Chapter 7

      A Proteomic Approach to the Inventory of the Human Centrosome (pages 123–142)

      Christopher J. Wilkinson, Jens S. Andersen, Matthias Mann and Erich A. Nigg

  3. Part III: The Centrosome in Development and Tissue Architecture

    1. Chapter 12

      The C. elegans Centrosome during Early Embryonic Development (pages 225–250)

      Laurence Pelletier, Thomas Müller-Reichert, Martin Srayko, Nurhan Özlü, Anne-Lore Schlaitz and Anthony A. Hyman

  4. Part IV: Centrosomes in Disease

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