Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective

Copyright © 2004 Wiley-VCH Verlag GmbH & Co. KGaA

Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective

Editor(s): Hugo Kubinyi, Gerhard Müller

Published Online: 12 JUL 2005

Print ISBN: 9783527309870

Online ISBN: 9783527603947

DOI: 10.1002/3527603948

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

Product Information

About The Product

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.
This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design.
With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xxiv)

    1. Introduction (pages 1–4)

      Dr. Gerhard Müller and Prof. Dr. Hugo Kubinyi

  3. Part I: General Aspects

    1. Chapter 1

      Target Family-Directed Masterkeys in Chemogenomics (pages 5–41)

      Dr. Gerhard Müller

    2. Chapter 2

      Drug Discovery from Side Effects (pages 43–67)

      Prof. Dr. Hugo Kubinyi

    3. Chapter 3

      The Value of Chemical Genetics in Drug Discovery (pages 69–96)

      Keith Russell and William F. Michne

    4. Chapter 4

      Structural Aspects of Binding Site Similarity: A 3D Upgrade for Chemogenomics (pages 97–135)

      Andreas Bergner and Judith Günther

  4. Part II: Target Families

    1. Chapter 5

      The Contribution of Molecular Informatics to Chemogenomics. Knowledge-Based Discovery of Biological Targets and Chemical Lead Compounds (pages 137–166)

      Edgar Jacoby, Ansgar Schuffenhauer and Pierre Acklin

    2. Chapter 6

      Chemical Kinomics (pages 167–190)

      Bert M. Klebl, Henrik Daub and György Kéri

    3. Chapter 7

      Structural Aspects of Kinases and Their Inhibitors (pages 191–219)

      Rogier Buijsman

    4. Chapter 8

      A Chemical Genomics Approach for Ion Channel Modulators (pages 221–242)

      Karl-Heinz Baringhaus and Gerhard Hessler

    5. Chapter 9

      Phosphodiesterase Inhibitors: A Chemogenomic View (pages 243–288)

      Martin Hendrix and Christopher Kallus

    6. Chapter 10

      Proteochemometrics: A Tool for Modeling the Molecular Interaction Space (pages 289–309)

      Jarl E. S. Wikberg, Maris Lapinsh and Peteris Prusis

  5. Part III: Chemical Libraries

    1. Chapter 11

      Some Principles Related to Chemogenomics in Compound Library and Template Design for GPCRs (pages 311–324)

      Thomas R. Webb

    2. Chapter 12

      Computational Filters in Lead Generation: Targeting Drug-Like Chemotypes (pages 325–339)

      Wolfgang Guba and Olivier Roche

    3. Chapter 13

      Navigation in Chemical Space: Ligand-Based Design of Focused Compound Libraries (pages 341–376)

      Gisbert Schneider and Petra Schneider

    4. Chapter 14

      Natural Product-Derived Compound Libraries and Protein Structure Similarity As Guiding Principles for the Discovery of Drug Candidates (pages 377–403)

      Marcus A. Koch and Herbert Waldmann

    5. Chapter 15

      Combinatorial Chemistry in the Age of Chemical Genomics (pages 405–432)

      Reni Joseph and Prabhat Arya

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      Subject Index (pages 433–463)

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